ID E0VZE7_PEDHC Unreviewed; 1051 AA.
AC E0VZE7;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=DNA polymerase theta, putative {ECO:0000313|EMBL:EEB18753.1, ECO:0000313|EnsemblMetazoa:PHUM530580-PA};
GN Name=8235159 {ECO:0000313|EnsemblMetazoa:PHUM530580-PA};
GN ORFNames=Phum_PHUM530580 {ECO:0000313|EMBL:EEB18753.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB18753.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18753.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB18753.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18753.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM530580-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM530580-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; AAZO01006439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235851; EEB18753.1; -; Genomic_DNA.
DR RefSeq; XP_002431491.1; XM_002431446.1.
DR AlphaFoldDB; E0VZE7; -.
DR STRING; 121224.E0VZE7; -.
DR EnsemblMetazoa; PHUM530580-RA; PHUM530580-PA; PHUM530580.
DR GeneID; 8235159; -.
DR KEGG; phu:Phum_PHUM530580; -.
DR CTD; 8235159; -.
DR VEuPathDB; VectorBase:PHUM530580; -.
DR eggNOG; KOG0950; Eukaryota.
DR HOGENOM; CLU_006553_0_0_1; -.
DR InParanoid; E0VZE7; -.
DR OMA; AGIVKFC; -.
DR OrthoDB; 208079at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18026; DEXHc_POLQ-like; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.20; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR046931; HTH_61.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048960; POLQ-like_helical.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF12; HELICASE POLQ-LIKE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF20470; HTH_61; 1.
DR Pfam; PF21099; POLQ_helical; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 287..459
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 503..695
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1051 AA; 117872 MW; 39B4B07459B75534 CRC64;
MNAQSTPVRK MHLRSRSRDS FSEITPIKKS KLLQNQVNNI SSSSIDQQLS ENVVLSNLHK
SRVKKKESLG ETSHKKRFSY DLFKEDTFDS AKGKSNISNS KNDSNDLGSL ANMCSEIKEM
FKDPFSNDTG CFLSDELISD SKLFQVIDSC SKINENGNNN INDFKDSSPV EFQVKKKVKE
NNSEILTVSD VMKWTDQSFL PKNNSMNLSN EIKQKLLDNV SNQELVKSQT TGWTQLNSSF
VSKVIEQDGE YEEMGPFYGL PLAVKKLYEE HKDIKELYSW QEECLNLESV KNHQNLVYAL
PTSGGKTLVA EILILREILC YKRNVLFILP YVSIVQEKVK DFSQFAIDLG FLVEEYAAGK
GVIPPIKRRR RKSVIIATME KALVVVNSLI EARRLHEFGL IVVDELHMLA EEGRGAILET
LLTQVIYNRD KIQIIGMTAT IGNLEEVGKF LKAECYVGNF RPVSLNEYIK CDRKIYSIDW
NSENGVKECR KLPLSAEGTD PDGISDLVQE VIPDDSCLIF CPSKKIVKRC FFLSRILPRD
LMKIKEQQKK SLYRALVSES NDQICPVLKK TLPFGVAYHH SGLTAGERKL LEESFRDGTL
SVICCTSTLA VGVNLPAKRV ILRSPYVGKD FISLSRYKQM VGRAGRSGYG AEGESFLMCQ
ITDLEKVKSL LKSPMDQTTS KIDLENCKNL VLSSIGLGTA TTRKSLRELL KCSLLHVQAN
KLNVDTKKMT DSCISSLYKQ GALKIKSIEL DEDKDVEGNS ISKLDLNNAT NTKKSLKISN
DSPLTISRLG RAAMKGGLSL DKAHELYGDL VKAQSSLVLL TNLHLLYLVT PPDIIAQIKP
NFSVYFNVYM ELNANEVHTA NIIGVTEFAM SKLAMGIHPK AIPEIVINRF YISLMLNKLW
KQHTVWDVAS LFELPRGQIQ TLMTSAATYA NSVLRFCEKL EKFWSFKSLL TDFAPRLAHC
CSTELLPLME LPAVKRGRAK QLYEGGFKTL QILANAKAGD LVRSIDHLSL KVASQIIAAA
KLLLMEKAEN LKEEAEDVLE GLAEKSGPKD I
//
