ID E0W462_PEDHC Unreviewed; 798 AA.
AC E0W462;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Spondin-1 {ECO:0000256|ARBA:ARBA00019594};
DE AltName: Full=F-spondin {ECO:0000256|ARBA:ARBA00030964};
GN Name=8239817 {ECO:0000313|EnsemblMetazoa:PHUM615930-PA};
GN ORFNames=Phum_PHUM615930 {ECO:0000313|EMBL:EEB20418.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB20418.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB20418.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB20418.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB20418.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM615930-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM615930-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; AAZO01007532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235886; EEB20418.1; -; Genomic_DNA.
DR RefSeq; XP_002433156.1; XM_002433111.1.
DR AlphaFoldDB; E0W462; -.
DR STRING; 121224.E0W462; -.
DR MEROPS; I02.978; -.
DR EnsemblMetazoa; PHUM615930-RA; PHUM615930-PA; PHUM615930.
DR GeneID; 8239817; -.
DR KEGG; phu:Phum_PHUM615930; -.
DR CTD; 8239817; -.
DR VEuPathDB; VectorBase:PHUM615930; -.
DR eggNOG; KOG3539; Eukaryota.
DR HOGENOM; CLU_014540_0_0_1; -.
DR InParanoid; E0W462; -.
DR OMA; KVQHFTH; -.
DR OrthoDB; 5404502at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00109; Kunitz-type; 1.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR InterPro; IPR009465; Spondin_N.
DR InterPro; IPR038678; Spondin_N_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR NCBIfam; NF038123; NF038123_dom; 1.
DR PANTHER; PTHR11311; SPONDIN; 1.
DR PANTHER; PTHR11311:SF23; SPONDIN-1; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF02014; Reeler; 1.
DR Pfam; PF06468; Spond_N; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS51019; REELIN; 1.
DR PROSITE; PS51020; SPONDIN; 1.
DR PROSITE; PS50092; TSP1; 3.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Hydrolase {ECO:0000313|EMBL:EEB20418.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..798
FT /note="Spondin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011412889"
FT DOMAIN 12..194
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 197..387
FT /note="Spondin"
FT /evidence="ECO:0000259|PROSITE:PS51020"
FT DOMAIN 655..705
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
SQ SEQUENCE 798 AA; 89458 MW; 97306C09506E7E5D CRC64;
MRRVFVVPVP LLLFFILGLT SHVDSTCLRQ PHFSQSVALK SPGDNGYQIH LNGNPDRYVP
GSSYVLSIKG GRNHQGYLQK FKGFVLTVEA SHPQSDIFHD TDGSDSPVRV GTFMLYSDEL
TQYHGECINT IKESDLSDKS EIQVMWQAPP KGSGCVTFRA MVLVDKDTWF ADDEGLSKKI
CEITPEYLRG TEDVESNTLE CCSCDEAKYT MVFEGLWSSS THPKDFPTNL WLTHFSDVIG
ATHRTNFSFW GEGQIASDGL RQVAEWGSAR NLEAELRSKA RNLKTLIKAA GLWHPHVNEN
TTATFKVDKQ KHLLSVVSMF GPTPDWIVGV SGLNLCQRDC TWVENKVIDL YPYDAGTDSG
VSYMSPNEPT IPRERISRIT PLYPEDPRAP FYDPQGKPMK PLAKLYLKLD YVTPKQCHED
VDGTVDLPPV VDLTENTEDT RRPECNVTDY TPWSPCSVTC GKGIRMRTRN YLMPQKAQML
GCDRQLVSKE MCVADQPSCS EGPFQYPSPF QYLPDSDEVE DTEAFCETSP FGEWSECSTT
CGVGVAMRTR RFLDRWGRKK CPHVSLVEKR ECIEPPCPSP SPGINMDSRC TTSEWTDWSP
CSATCGTGLR YRSRQVLVGG ELKDICAGRV ELNQQRICTL QADCSVDRTS AKQICMLEPD
SGPCRGFFER WYFDPREKQC VTFPFGGCRG NRNNFKLESE CNEACGTIRD ELILAESELR
RGGGGDGSFS SLSSFYRPNN GTRIDCVVDD WTDWTPCSVS CGVGKSVKMR MVKVQPQNGG
RPCPKRLLKK RVCQGPPC
//