ID E0XJ33_9NIDO Unreviewed; 272 AA.
AC E0XJ33;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 28-JUN-2023, entry version 30.
DE RecName: Full=Replicase polyprotein 1ab {ECO:0000256|ARBA:ARBA00022087};
DE AltName: Full=ORF1ab polyprotein {ECO:0000256|ARBA:ARBA00029611};
DE Flags: Fragment;
OS Bat coronavirus BR98-53/BGR/2008.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Coronavirinae.
OX NCBI_TaxID=864617 {ECO:0000313|EMBL:ADK66881.1};
RN [1] {ECO:0000313|EMBL:ADK66881.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BtCoV/BR98-53/BGR/2008 {ECO:0000313|EMBL:ADK66881.1};
RX PubMed=20686038; DOI=10.1128/JVI.00650-10;
RA Drexler J.F., Gloza-Rausch F., Glende J., Corman V.M., Muth D.,
RA Goettsche M., Seebens A., Niedrig M., Pfefferle S., Yordanov S.,
RA Zhelyazkov L., Hermanns U., Vallo P., Lukashev A., Muller M.A., Deng H.,
RA Herrler G., Drosten C.;
RT "Genomic characterization of severe acute respiratory syndrome-related
RT coronavirus in European bats and classification of coronaviruses based on
RT partial RNA-dependent RNA polymerase gene sequences.";
RL J. Virol. 84:11336-11349(2010).
CC -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family.
CC {ECO:0000256|ARBA:ARBA00008087}.
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DR EMBL; GU190248; ADK66881.1; -; Genomic_RNA.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR046441; RdRp_CoV.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS51948; COV_NSP12_RDRP; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000313|EMBL:ADK66881.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..272
FT /note="Nsp12 RNA-dependent RNA polymerase"
FT /evidence="ECO:0000259|PROSITE:PS51948"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADK66881.1"
FT NON_TER 272
FT /evidence="ECO:0000313|EMBL:ADK66881.1"
SQ SEQUENCE 272 AA; 30325 MW; 54A552EFF5E899DB CRC64;
VAYHVVKRYF DIYEGGCIAA RDVVVTNLNK SAGYPLNKFG KASLYYESLS YEEQDALYAL
TKRNVLPTMT QLNLKYAISG KERARTVGGV SLLSTMTTRQ FHQKHLKSIV NTRNATVVIG
TTKFYGGWDN MLRNLMDGVD NACLMGWDYP KCDRALPNMI RMISAMILGS KHVNCCTNSD
RYYRLCNELA QVLTEVVYSN GGFYMKPGGT TSGDATTAYA NSVFNIFQAV SANINRILGI
NSNTCNNLTV KSLQRMLYDN CYRSSAVDPG FV
//
