ID   E0XTW4_9PROT            Unreviewed;       298 AA.
AC   E0XTW4;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Dihydrodipicolinate synthase/n-acetylneuraminate lyase {ECO:0000313|EMBL:ADI17855.1};
OS   uncultured Rhodospirillales bacterium HF0200_01O14.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   environmental samples.
OX   NCBI_TaxID=710787 {ECO:0000313|EMBL:ADI17855.1};
RN   [1] {ECO:0000313|EMBL:ADI17855.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20695878; DOI=10.1111/j.1462-2920.2010.02314.x;
RA   Rich V.I., Pham V.D., Eppley J., Shi Y., DeLong E.F.;
RT   "Time-series analyses of Monterey Bay coastal microbial picoplankton using
RT   a 'genome proxy' microarray.";
RL   Environ. Microbiol. 13:116-134(2011).
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
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DR   EMBL; GU474875; ADI17855.1; -; Genomic_DNA.
DR   AlphaFoldDB; E0XTW4; -.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128:SF74; BLL4423 PROTEIN; 1.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365}.
FT   ACT_SITE        136
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        164
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         206
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   298 AA;  32713 MW;  4E8AAE967B750BD0 CRC64;
     MQVNWTGVFP AVATQMNEDG SIDFDMTAEQ IEALITAGVD GLVMLGSVGE NTALEPDEKI
     AVLKLAVEVT KGRIPVLSGV AENSTRAAIR YVQACEELGA DGLMLLPGMV YTADPRENIE
     HFRTVAGATK LPIMIYNNPG AYRIDIKPEE FNQLADVKNL VAIKESSGDP RRITDIYNAC
     GDRFVLFCGM DDLVMETQVL GAVGWISGFT DAFPKESVAL WKLLSEGKYK EALSIYRWFT
     PVLHMDVHAK LVQYIKLAQE MTGVGKAHVR APRLPLVGKE LETIKAEIQK AIDTRPSL
//