ID   E0Y1F2_9PROT            Unreviewed;       581 AA.
AC   E0Y1F2;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Adenylate cyclase, family 3 (Some proteins contain hamp domain) {ECO:0000313|EMBL:ADI20493.1};
OS   uncultured alpha proteobacterium EB080_L58F04.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; environmental samples.
OX   NCBI_TaxID=710798 {ECO:0000313|EMBL:ADI20493.1};
RN   [1] {ECO:0000313|EMBL:ADI20493.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20695878; DOI=10.1111/j.1462-2920.2010.02314.x;
RA   Rich V.I., Pham V.D., Eppley J., Shi Y., DeLong E.F.;
RT   "Time-series analyses of Monterey Bay coastal microbial picoplankton using
RT   a 'genome proxy' microarray.";
RL   Environ. Microbiol. 13:116-134(2011).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GU474942; ADI20493.1; -; Genomic_DNA.
DR   AlphaFoldDB; E0Y1F2; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 3.40.50.10070; TolB, N-terminal domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SUPFAM; SSF81901; HCP-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          31..88
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REPEAT          451..484
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   581 AA;  64626 MW;  73413544C26B9053 CRC64;
     MKLFSQAFLR STHGRLFNTG GDSFLAEFPS AVSAVECAVD FQSVIKERNA SDDTSVKLEF
     RIGINSGDVV KEKDNLLGDG VNIAARLEAL AQTNGITVSK VIYDYVKGKT KYDFNDLGIQ
     KVKQNEFHAF DLLLEPSQKR TIKRDRTFLK LLISSICVVL LALGGYVVSV SQNPNEQASN
     ETSSKAVVSS LPVILVYPFD DLGASATTDD LSPAFTESLI SSLSRYSRIS VLSSSTSMDA
     KAKEAKDPFI KKKYNADYVV RGSIQTFSDQ SRIQMQLSDL KLNKVVWTDK VDFSANQIFE
     VQDSIGDKIL THLQINAVEG GEVKSWAAKY GTTERLTLFL NSRKEWFKFT PDGYKNHTDI
     VHLLEDQMGA GNPALYNVRA WNLFLKRAVG LAPDLEKNGA EIIRLANLDI AENQDVTAFN
     LRALAEFRLG SKDCDLSKEY AQKAYDLGAT VDTFIVSGTI WVECGDLKEG TKFFENALRL
     QPNDSGWNLT KRLIPMYYVQ GEYEKISDLV EPHIDALDIA PEMLAFYAFS INEAGDSEKA
     KELLRRAKDL GVSKVSLERV IRDTDKTIDF ISKLSDIGSI E
//