ID E1B803_BOVIN Unreviewed; 379 AA.
AC E1B803;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Pregnancy-associated glycoprotein 15 {ECO:0000313|Ensembl:ENSBTAP00000049431.3};
GN Name=PAG15 {ECO:0000313|Ensembl:ENSBTAP00000049431.3};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000049431.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000049431.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000049431.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000049431.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000049431.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR AlphaFoldDB; E1B803; -.
DR Ensembl; ENSBTAT00000057046.3; ENSBTAP00000049431.3; ENSBTAG00000054191.1.
DR VEuPathDB; HostDB:ENSBTAG00000054191; -.
DR eggNOG; KOG1339; Eukaryota.
DR GeneTree; ENSGT00940000153747; -.
DR HOGENOM; CLU_013253_3_0_1; -.
DR TreeFam; TF314990; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000054191; Expressed in semen and 6 other cell types or tissues.
DR ExpressionAtlas; E1B803; baseline.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..379
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018777638"
FT DOMAIN 71..376
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 89
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 270
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 102..107
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 261..265
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 379 AA; 42250 MW; 6B3B08987082FCFD CRC64;
MKWLVLLGLV AFSECVVKIP LRRVKTMTKT LSGKNMLNNF LKEHAYRLSQ ISFHGSNLTI
HPLRNIRDLF YMGNITIGTP PQEFLVVFDT GSSDLWVPSD FCTSPACSKH FRFRHLQSST
FRLTNKTFSI EYGSGTMEGI VAHDTVRIGD LVSTDQPFGL SMTESGFEGI PFDGVLGLNY
PNISFSGAIP IFDKLKNQGA ISEPVFAFYL SKDEQEGSVV MFGGVDHRYY KGELKWVPLI
EAGDWIVHMD CISMRRKVIA CSGGCEAVVD TGVSMIKGPK TLVDNIQKLI GATLRVSTHN
KDLQVDTLPS ITFTINGINY RVPARAYILK DSRGCCYSSF QETTVSPSTE TWILGDVFLR
LYFSVFDRGN DRIGLARAV
//
