ID E1BCJ5_BOVIN Unreviewed; 819 AA.
AC E1BCJ5;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Discs large MAGUK scaffold protein 2 {ECO:0000313|Ensembl:ENSBTAP00000039964.5};
GN Name=DLG2 {ECO:0000313|Ensembl:ENSBTAP00000039964.5,
GN ECO:0000313|VGNC:VGNC:112654};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000039964.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000039964.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000039964.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000039964.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000039964.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; E1BCJ5; -.
DR Ensembl; ENSBTAT00000040186.5; ENSBTAP00000039964.5; ENSBTAG00000027868.6.
DR VEuPathDB; HostDB:ENSBTAG00000027868; -.
DR VGNC; VGNC:112654; DLG2.
DR GeneTree; ENSGT00940000155156; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000027868; Expressed in prefrontal cortex and 88 other cell types or tissues.
DR ExpressionAtlas; E1BCJ5; baseline and differential.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12032; SH3_DLG2; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR035759; DLG2_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF6; DISKS LARGE HOMOLOG 2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 65..152
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 160..247
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 388..469
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 503..573
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 629..804
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
SQ SEQUENCE 819 AA; 91041 MW; A79706791CBD9803 CRC64;
MQRPSASRAE NYQLLWDTIA SLKQCEQAMQ HAFIPASPAP IIVNTDTLDT IPYVNGTEIE
YEFEEITLER GNSGLGFSIA GGTDNPHIGD DPGIFITKII PGGAAAEDGR LRVNDCILRV
NEVDVSEVSH SKAVEALKEA GSIVRLYVRR RRPILETVVE IKLFKGPKGL GFSIAGGVGN
QHIPGDNSIY VTKIIDGGAA QKDGRLQVGD RLLMVNNYSL EEVTHEEAVA ILKNTSDVVY
LKVGKPTTIY MTDPYGPPDI THSYSPPMEN HLLSGNNGTL EYKTSLPPIS PGRYSPIPKH
MLVEDDYTRP PEPVYSTVNK LCDKPASPRH YSPVECDKSF LLSAPYPHYH LGLLPDSEMT
SHSQHSTATR QPSVTLQRAI SLEGEPRKVV LHKGSTGLGF NIVGGEDGEG IFVSFILAGG
PADLSGELQR GDQILSVNGI DLRGASHEQA AAALKGAGQT VTIIAQYQPE DYARFEAKIH
DLREQMMNHS MSSGSGSLRT NQKRSLYVRA MFDYDKSKDS GLPSQGLSFK YGDILHVINA
SDDEWWQARR VTLEGDSEEM GVIPSKRRVE RKERARLKTV KFNAKPGVID SKGDIPGLGD
DGYGTKTLRG QEDCILSYEP VTRQEINYTR PVIILGPMKD RINDDLISEF PDKFGSCVPH
TTRPKRDYEV DGRDYHFVIS REQMEKDIQE HKFIEAGQYN DNLYGTSVQS VRFVAERGKH
CILDVSGNAI KRLQVAQLYP IAIFIKPKSL EPLMEMNKRL TEEQAKKTYD RAIKLEQEFG
EYFTAIVQGD TLEDIYNQCK LVIEEQSGPF IWIPSKEKL
//
