ID E1BDD7_BOVIN Unreviewed; 905 AA.
AC E1BDD7;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Epithelial cell transforming 2 like {ECO:0000313|Ensembl:ENSBTAP00000038945.3};
GN Name=ECT2L {ECO:0000313|Ensembl:ENSBTAP00000038945.3,
GN ECO:0000313|VGNC:VGNC:28315};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000038945.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000038945.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000038945.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000038945.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000038945.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001178468.1; NM_001191539.1.
DR AlphaFoldDB; E1BDD7; -.
DR SMR; E1BDD7; -.
DR PaxDb; 9913-ENSBTAP00000038945; -.
DR Ensembl; ENSBTAT00000039145.4; ENSBTAP00000038945.3; ENSBTAG00000027312.5.
DR GeneID; 100141063; -.
DR KEGG; bta:100141063; -.
DR CTD; 345930; -.
DR VEuPathDB; HostDB:ENSBTAG00000027312; -.
DR VGNC; VGNC:28315; ECT2L.
DR eggNOG; KOG0274; Eukaryota.
DR eggNOG; KOG3524; Eukaryota.
DR GeneTree; ENSGT00940000158839; -.
DR HOGENOM; CLU_013595_0_0_1; -.
DR OrthoDB; 2910789at2759; -.
DR TreeFam; TF343796; -.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000027312; Expressed in semen and 44 other cell types or tissues.
DR ExpressionAtlas; E1BDD7; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd22173; F-box_ECT2L; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR025592; DUF4347.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR46857; EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE; 1.
DR PANTHER; PTHR46857:SF1; EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE; 1.
DR Pfam; PF14252; DUF4347; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 567..755
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
SQ SEQUENCE 905 AA; 104963 MW; 443B67ED865F608D CRC64;
MESFHTRFSA WTPFSNKSLN RQLFQERVAL ISHWFDLWTN KQRQEFLFTI FLRCTKSQLR
VIQDWFSERM QVAKVDFSTV LPRFISLYIF SFLNPKDLCA AAQVSWPWKF LTEQDCLWMP
KCIKFGWFLP YTPTDNEYGA WKHHYIACVS NLDWLTPREA AAVYGTLNEP KTEDEELQER
QRERCLRKII WEKIALHKKE LFKVRPPWVS GTHCSRLFKS KCQPRLSQTA RDRVELHETL
EKQLVLSSLE SLPKRSNISG RHSYPLLSKK SWRGVYKNDS GSSNALQPHF ILISSRIPAY
EMVANSVRAG IISVVYEHSG LTLETLLYLI EKALDGQMAQ SVGIFSDGDS REINLLQGYK
IGIKNLLRPE VRDFWEKLGS YVAPEEEGGH VDLFVPLGAS EAGIEVLSQL SQLTGTLFTA
PTGIATGSYQ HLLSDWLGRQ WETAPPSIYF SESKLQTWSS LTDFLEDTLK SVRKQLSPLF
KELQKNISGR MIGQFVFDTM SVANILNNQE IIQALADGLI ELSKENSERD VIEDNPQDTK
PSLSKNDPNF ELLVKLERKL QLDSAEKRTR VVRELLQSER KYVQMLEIVR DVYVRPLRAA
LSSNRAILSA ANIQIMFSDI LQILCLNRRF LDDLRDRLQE WGPAHCVGEI FIKFGSQLNT
YTNFFNNYPV VLKTIEKCRE MIPAFRAFLK RHDKTIVTKM LSLPELLLYP SRRFEEYIHL
LYALRLHTPA EHIDRGNLTI AIDQMKNYKG YIDQMKRNIS MKDHLLDIQR LIWGCPTLSE
ANRYLIRVQD VAQLHCCDED ISFYLRLYEH TCDLSLFLFN DALLVSSRGI SHTPFEKTSK
STYQFIASVA LHRLIIEDIP DSKFIKNAFI LQGPKHEWIC ATEVEDDKFL WLSVLQNAIK
SSMEK
//
