ID E1BH14_BOVIN Unreviewed; 367 AA.
AC E1BH14;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Left-right determination factor {ECO:0000256|PIRNR:PIRNR037402};
GN Name=LOC100336971 {ECO:0000313|Ensembl:ENSBTAP00000003702.4};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000003702.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000003702.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003702.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000003702.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003702.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR037402}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR037402,
CC ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_015322250.1; XM_015466764.1.
DR RefSeq; XP_015330550.1; XM_015475064.1.
DR AlphaFoldDB; E1BH14; -.
DR STRING; 9913.ENSBTAP00000003702; -.
DR PaxDb; 9913-ENSBTAP00000049627; -.
DR Ensembl; ENSBTAT00000003702.4; ENSBTAP00000003702.4; ENSBTAG00000054752.1.
DR GeneID; 100336971; -.
DR KEGG; bta:100336971; -.
DR VEuPathDB; HostDB:ENSBTAG00000054752; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00390000010056; -.
DR HOGENOM; CLU_064098_0_0_1; -.
DR InParanoid; E1BH14; -.
DR OMA; VSVYWVQ; -.
DR OrthoDB; 5391376at2759; -.
DR TreeFam; TF106462; -.
DR Reactome; R-BTA-114608; Platelet degranulation.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000054752; Expressed in liver and 22 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR GO; GO:0009948; P:anterior/posterior axis specification; IBA:GO_Central.
DR CDD; cd13758; TGF_beta_LEFTY1_2; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR003942; LRDF.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF226; LEFT-RIGHT DETERMINATION FACTOR; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PIRSF; PIRSF037402; TGFb4; 1.
DR PRINTS; PR01427; TGFBETA4.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Cytokine {ECO:0000256|PIRNR:PIRNR037402};
KW Developmental protein {ECO:0000256|PIRNR:PIRNR037402};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR037402};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037402};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..367
FT /note="Left-right determination factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030168161"
FT DOMAIN 241..355
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 367 AA; 41470 MW; D6A04906AFAE7A7C CRC64;
MQPLWLCWAL WALPLAGPGV ALMEEWILDS LLQQLHLSKV PIVDKATVEG LVIPAHVRTQ
YVALLQRGHG ARSRGKRFSQ NFREVVGRFL ESEASSYLLV FDMEQRLPPR SELVQAVLRL
FQEPVPRAAL RRHERLFPRS DRARVTVQWL HVRDDGSNRT ALIDSRLVTI HESGWKALDV
TEAVNFWQQL RSPRQPLLLQ VLVQREHLGP LASSAHRLVR FAPQGPSSGR QGEPQLELHT
LDLRDYGAQG NCDPKAPVTK GTRCCRQEMY IDLQGMKWAE NWVLEPPGFL AYECVGTCQQ
PPESLTFKWP FLGPRQCIAS ETTSLPMIVS IQEGGRLQPH VVSLPNMRVQ TCSCASDGAL
VPRKLEP
//
