ID E1BKB4_BOVIN Unreviewed; 1203 AA.
AC E1BKB4;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Tubulin tyrosine ligase like 4 {ECO:0000313|Ensembl:ENSBTAP00000024502.4};
GN Name=TTLL4 {ECO:0000313|Ensembl:ENSBTAP00000024502.4,
GN ECO:0000313|VGNC:VGNC:36492};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000024502.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000024502.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000024502.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000024502.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000024502.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR STRING; 9913.ENSBTAP00000024502; -.
DR PaxDb; 9913-ENSBTAP00000024502; -.
DR Ensembl; ENSBTAT00000024502.4; ENSBTAP00000024502.4; ENSBTAG00000018415.4.
DR Ensembl; ENSBTAT00000069658.1; ENSBTAP00000062435.1; ENSBTAG00000018415.4.
DR VEuPathDB; HostDB:ENSBTAG00000018415; -.
DR VGNC; VGNC:36492; TTLL4.
DR eggNOG; KOG2156; Eukaryota.
DR GeneTree; ENSGT00940000157916; -.
DR HOGENOM; CLU_007870_0_0_1; -.
DR OMA; RNCMEVL; -.
DR TreeFam; TF313087; -.
DR Reactome; R-BTA-8955332; Carboxyterminal post-translational modifications of tubulin.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000018415; Expressed in spermatid and 102 other cell types or tissues.
DR GO; GO:0097731; C:9+0 non-motile cilium; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR GO; GO:0070740; F:tubulin-glutamic acid ligase activity; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0120222; P:regulation of blastocyst development; IEA:Ensembl.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241:SF162; TUBULIN MONOGLUTAMYLASE TTLL4; 1.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1114..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1203 AA; 133803 MW; 1BCAA75CEBC2B673 CRC64;
MWAPHGLSKN RALRYQPPPG TQLEAEWAHG HSTYPVTEKP SEGKVWAQAH QQVKPIWRLE
KKHVGTLSAG LGPGLLGAPP QPAYFFCPST LCSSGTTAVT AGHSNCCYLH SLPDLFSSTL
LYRRSNYRHK AYQQLESFCL RSSPSEKRPF SLPQKRLPVR LPANKATSSK LIPMASSSTE
PYSSLGAAGE SLSGRSLASA ISGKTPSPLP SSSSSYKPML NNNSFMRPNS TKVPLSQATE
GLKPVSSPKV QLISWQHSGG TGDCAFQSVE HKAPKSSGPA LDDAPPHNML STPSSLDTSA
TSVASSFYSQ SNLVTRTQSY PYGLKGDPVS QTLTKEVRFT EAVRKLTARG LEKKPRQGYH
FEQTYFMNPS LQWDLLNQNR RWKPPVASQQ VPQEDAGADN RALPAVSDPG GLDSAVFCTK
RISIHLLASH TNGLSYSPAC GSTIDSPLLG EDKTPVPPSP SQPLGVAEVA TRLSSIHLGK
LGREGPKEAR ELNSPPRTVG SATDLQLDPV ETEDLEEELL DGLEDCCSQV ENEEEEGDSE
CSSCSAVSPS ESVAVISRNC MEFLTKPLSN EKVVRPALIY SLFPNVPPTI YFGTPDERVE
KLPWEQRKLL RWKMSTVTPN IVKQTIGRSH FKISKRNDDW LGCWGHHMKS PSFRSIQEHQ
KLNHFPGSFQ IGRKDRLWRN LSRMQSRFGK KEFSFFPQSF ILPQDAKLLR KAWESGSRQK
WIVKPPASAR GIGIQVIHKW SQLPKRRPLL VQRYLHKPYL ISGSKFDLRI YVYVTSYDPL
RIYLFSDGLV RFASCKYSPS MKSLGNKFMH LTNYSVNKKN AEYQANEDET ACQGHKWALK
ALWSYLSQKG VNSDAIWEKI KDVVVKTIIS SEPYVTSLLK MYVRRPYSCH ELFGFDVMLD
EKLKPWVLEV NISPSLHSNS PLDISIKGQM IRDLLNLAGF VLPNADDIAS SSSSSSSSTT
SLPSSPRDRC RVAPEYFTAQ KMKKAYYLTQ KIPDQDFYAS VLDVLTPDDV RVLVEMEDEF
SRRGQFERIF PSRISSRYLR FFEQPRYFNI LTTQWEQKYH GNKLKGVDLL RSWCYKGFHT
GAISDSAPVW TLPASVLTVP KADATLSDFS KPETVKLRKH GSTERNIPLS EDGTMPKLKK
TQAGLSSPPR KLSSSEDSED TSKEPSLSTQ LLPVIKFSGQ TSRLSASTSS QSAGGSLLAA
VSL
//
