ID E1BL46_BOVIN Unreviewed; 328 AA.
AC E1BL46;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Carbonic anhydrase-related protein 11 {ECO:0000256|ARBA:ARBA00041142};
DE AltName: Full=CA-RP XI {ECO:0000256|ARBA:ARBA00042748};
GN Name=CA11 {ECO:0000313|Ensembl:ENSBTAP00000008890.6,
GN ECO:0000313|VGNC:VGNC:26649};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000008890.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000008890.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000008890.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000008890.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000008890.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Does not have a catalytic activity.
CC {ECO:0000256|ARBA:ARBA00002258}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00010718}.
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DR AlphaFoldDB; E1BL46; -.
DR SMR; E1BL46; -.
DR PaxDb; 9913-ENSBTAP00000008890; -.
DR Ensembl; ENSBTAT00000008890.6; ENSBTAP00000008890.6; ENSBTAG00000006757.6.
DR VEuPathDB; HostDB:ENSBTAG00000006757; -.
DR VGNC; VGNC:26649; CA11.
DR eggNOG; KOG0382; Eukaryota.
DR GeneTree; ENSGT00940000162098; -.
DR HOGENOM; CLU_039326_7_0_1; -.
DR InParanoid; E1BL46; -.
DR OMA; HKNQNAC; -.
DR TreeFam; TF352926; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000006757; Expressed in cerebellum and 100 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR GO; GO:0016836; F:hydro-lyase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
DR CDD; cd03121; alpha_CARP_X_XI_like; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR InterPro; IPR041878; Alpha_CARP_X/XI.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR PANTHER; PTHR18952; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR18952:SF93; CARBONIC ANHYDRASE-RELATED PROTEIN 11; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..328
FT /note="Carbonic anhydrase-related protein 11"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018661197"
FT DOMAIN 33..303
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
FT REGION 300..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 36116 MW; 29C3DEFC69376C56 CRC64;
MGAAARLSAP RALVLWAALG AAAHIGPAPD PEDWWSYKDN LQGNFVPGPP FWGLVNAAWS
LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL YNTGRHVSFL PAPRPVVNVS
GGPLLYSHRL SELRLLFGAR DGAGSEHQIN HQGFSAEVQL IHFNQELYGN LSAATRGPNG
LAILSLFVNV AGSSNPFLSR LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS
LSTPPCSETV TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNGRP LQPLAHRALR
GNRDPRHPER RCRGPNYRLH VDGAPHGR
//
