ID   E1BMZ0_BOVIN            Unreviewed;       629 AA.
AC   E1BMZ0;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=EF-hand calcium binding domain 7 {ECO:0000313|Ensembl:ENSBTAP00000003365.5};
GN   Name=EFCAB7 {ECO:0000313|Ensembl:ENSBTAP00000003365.5,
GN   ECO:0000313|VGNC:VGNC:28347};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000003365.5, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000003365.5, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003365.5,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000003365.5}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003365.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; NP_001178979.1; NM_001192050.1.
DR   STRING; 9913.ENSBTAP00000069321; -.
DR   PaxDb; 9913-ENSBTAP00000003365; -.
DR   Ensembl; ENSBTAT00000003365.6; ENSBTAP00000003365.5; ENSBTAG00000002600.6.
DR   Ensembl; ENSBTAT00000077442.1; ENSBTAP00000069321.1; ENSBTAG00000002600.6.
DR   GeneID; 505160; -.
DR   KEGG; bta:505160; -.
DR   CTD; 84455; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002600; -.
DR   VGNC; VGNC:28347; EFCAB7.
DR   eggNOG; KOG0027; Eukaryota.
DR   GeneTree; ENSGT00390000015466; -.
DR   HOGENOM; CLU_031520_1_0_1; -.
DR   OMA; KTIDKYW; -.
DR   OrthoDB; 23056at2759; -.
DR   TreeFam; TF329354; -.
DR   Reactome; R-BTA-5635838; Activation of SMO.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000002600; Expressed in oocyte and 111 other cell types or tissues.
DR   GO; GO:0060170; C:ciliary membrane; IBA:GO_Central.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR   GO; GO:1903569; P:positive regulation of protein localization to ciliary membrane; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0120229; P:protein localization to motile cilium; IEA:Ensembl.
DR   GO; GO:0008589; P:regulation of smoothened signaling pathway; IEA:Ensembl.
DR   CDD; cd00051; EFh; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   PANTHER; PTHR46819; EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7; 1.
DR   PANTHER; PTHR46819:SF1; EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 3.
DR   SUPFAM; SSF47473; EF-hand; 2.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          102..137
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          192..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   629 AA;  71637 MW;  BEEC6D42D7EA203D CRC64;
     MAISPGSDAA FSGQKPTHSE SPRSKKFLLT EEEIFYMNCR AAYLTVFKSS LDNIISKDQL
     YLALQHAGRN PSQKTINKYW TSQTAKLNFD DFCIILRKEK PTSKAELLKS FKQLDVNDNG
     SILHTDLYKL LTKKGEKMTR EEVNAIINLA DVNADGKFDY IKFCKLYMAT NEQCLKTTLE
     KLEVDSKLRR QQFGSHVEGS PERAPSPVAK ASPRIIRKAD QESFSNKGDT RNSSLATARQ
     FKTSVSFTVT MGADSNQNSK LIEPHSIKEW QCVQSKGCFF LEEDGEIISH QYKMQIAQRS
     LVYITIKPLS LSQAEGKPSP WLSVDTALYI LKENESQANL QLLYFTELRN RETFGWTGEL
     GPGIYWLVPS TTGCRLRKEV KPVTEEAQLV YRDETGELFL TKEFRSTLSD IFEVIDLDGN
     GLLSLEEYNF FELRTSGEKC DEDAWAVCRE NFDTKKNELT RQGFMDLNLM EANDREGDPR
     DLWVTLHSMG YNKALELTEA CPFVIDIYAD KCKPRIKAVH MEACSGQLEK AICKSVLNKG
     NAKVMDGYEN IIIYTYKRDT WITAVIENKS DDKVIIHVNN ELSENCVNNR GLGIFAVEVA
     PNSTMVCQHV MPLNERQEWI YYCVYSLIS
//