ID E1BNN3_BOVIN Unreviewed; 583 AA.
AC E1BNN3;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Ral GEF with PH domain and SH3 binding motif 2 {ECO:0000313|Ensembl:ENSBTAP00000033902.4};
GN Name=RALGPS2 {ECO:0000313|Ensembl:ENSBTAP00000033902.4,
GN ECO:0000313|VGNC:VGNC:33705};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000033902.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000033902.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000033902.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000033902.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000033902.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005217216.1; XM_005217159.3.
DR RefSeq; XP_015330654.1; XM_015475168.1.
DR AlphaFoldDB; E1BNN3; -.
DR SMR; E1BNN3; -.
DR STRING; 9913.ENSBTAP00000033902; -.
DR PaxDb; 9913-ENSBTAP00000033902; -.
DR Ensembl; ENSBTAT00000034000.5; ENSBTAP00000033902.4; ENSBTAG00000010718.6.
DR GeneID; 789713; -.
DR CTD; 55103; -.
DR VEuPathDB; HostDB:ENSBTAG00000010718; -.
DR VGNC; VGNC:33705; RALGPS2.
DR eggNOG; KOG3417; Eukaryota.
DR GeneTree; ENSGT00940000154079; -.
DR HOGENOM; CLU_021333_0_1_1; -.
DR InParanoid; E1BNN3; -.
DR OMA; QAYATTQ; -.
DR OrthoDB; 68574at2759; -.
DR TreeFam; TF352150; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000010718; Expressed in spermatid and 107 other cell types or tissues.
DR ExpressionAtlas; E1BNN3; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd13310; PH_RalGPS1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF357; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 49..287
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 457..569
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 283..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 65200 MW; 7E576D3CADF24F03 CRC64;
MDLMNGQASN VNIAATASEK SSSSESLSDK GSELKKSFDA VVFDVLKVTP EEYAGQITLM
DVPVFKAIQP DELASCGWNK KEKYSSAPNA VAFTRRFNHV SFWVVREILH AQTLKIRAEV
LSHYIKTAKK LYELNNLHAL MAVVSGLQSA PIFRLTKTWA LLSRKDKTTF EKLEYVMSKE
DNYKRLRDYI SSLKMTPCIP YLGIYLSDLT YIDSAYPSTG SILENEQRSN LMNNILRIIS
DLQQSCEYDI PMLPHVQKYL NSVQYIEELQ KFVEDDNYKL SLKIEPGTST PRSAASREDL
VGPEVGASPQ SGRKSMAAEG ALLPQTPPSP RNLIQHGHRK CHSLGYNFIH KMNTAEFKSA
TFPNAGPRHL LDDSVMEPHA PSRGQAESST LSSGISIGSS DGSELSEETS WPAFERNRLY
HSLGPVTRVA RNGYRSHMKA SSSAESEDLA VHLYPGAVTI QGVLRRKTLL KEGKKPTVAS
WTKYWAALCG TQLFYYAAKS LKATERKHFK STSNKNVSVV GWMVMMADDP EHPDLFLLTD
SEKGNSYKFQ AGSRMNAMLW FKHLSAACQS NKQQVPTNLM TFE
//
