ID   E1BQN2_CHICK            Unreviewed;      1577 AA.
AC   E1BQN2;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=FYVE, RhoGEF and PH domain containing 5 {ECO:0000313|Ensembl:ENSGALP00010032271.1};
GN   Name=FGD5 {ECO:0000313|Ensembl:ENSGALP00010032271.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010032271.1, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00010032271.1}
RP   IDENTIFICATION.
RC   STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010032271.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
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DR   RefSeq; XP_004944789.1; XM_004944732.2.
DR   SMR; E1BQN2; -.
DR   STRING; 9031.ENSGALP00000013906; -.
DR   PaxDb; 9031-ENSGALP00000013906; -.
DR   Ensembl; ENSGALT00010053557.1; ENSGALP00010032271.1; ENSGALG00010022028.1.
DR   GeneID; 416130; -.
DR   KEGG; gga:416130; -.
DR   CTD; 152273; -.
DR   VEuPathDB; HostDB:geneid_416130; -.
DR   GeneTree; ENSGT00940000157922; -.
DR   InParanoid; E1BQN2; -.
DR   OMA; EDHEPPD; -.
DR   OrthoDB; 5385125at2759; -.
DR   Reactome; R-GGA-9013149; RAC1 GTPase cycle.
DR   Proteomes; UP000000539; Chromosome 12.
DR   Bgee; ENSGALG00000008546; Expressed in lung and 11 other cell types or tissues.
DR   ExpressionAtlas; E1BQN2; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd15742; FYVE_FGD5; 1.
DR   CDD; cd15792; PH1_FGD5; 1.
DR   CDD; cd13237; PH2_FGD5_FGD6; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000306; Znf_FYVE.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF13; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 5; 1.
DR   Pfam; PF01363; FYVE; 1.
DR   Pfam; PF00169; PH; 2.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00064; FYVE; 1.
DR   SMART; SM00233; PH; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ   SEQUENCE   1577 AA;  175946 MW;  8CA61146F3BBC0F1 CRC64;
     MNNTELTKPP LAPKPKIIGH LSPVAISKFS PSLPRSDILH NPNSMSRGPK PPIAPKPKLS
     ADTESRSSVN TNNNLNKCSN CKLLCLDGEL CDGNQCSAEC PEAEADDEYI VLPETQLTNK
     DCNDLEHKHD QSLDSFAVNE VLEIPEEAEK EEDNIPNHES ADSQEIKHHN FSDIAEPIKP
     DSVSSTRDRG QSEAFCEELS DATGGNNDVS KNVDEDKDVA GDCSETRSKE ETSNNLKLVK
     DSDDSKTDGD NILNRDEGDV CGDIILTPLT AAELIPSLEK SGEEKEEELS EILGKGDRCP
     AHDGDHSVYA ELDLNMQDEL ENDDCTSPDM LPNEASEKTV WCLELPEGEP NAENGLGDST
     HQAAAEEEEA DTDKHNNTNT GNVSDDCQIT DLRGEETSEV ACEASKDSGK REEETVNAES
     INDGCQIAPS ENDDGEEVPT NRQTEETCPE EDGQISDTLP SGPGMETKLE DMSAEEHNES
     IAEMSKSDEL QLEGNKVETD SLSKSDLSPT QLVPCKEEIE VCKHGKMNVK HRTKNVLHEK
     LALPEVVIVP EESERRETGS DSLDDPYVLP AENEFTHKGQ TDSGADHSKR DELDMDGESN
     LLLIDRKSIV TRTRSLSGRM PGYVPETVPE EGGPETDLPP SCNSSGTEDL SNSSFSVEGK
     TLEDNKALPS KPRHFILYPR SYSVEGREIP ISIYKEGDGC VLSDIRMKKT EDNLSLPCVN
     GSSHIFSQGN LSSGAVSTPS SVVDIPPPFE LAYITKKPIT KSSPSLLIEN ESPDKYSKKK
     KSSFKRFLTL KFKKKTENKI HVDVNVSSSR SSSESSYHGP PRLMELDRTL SSSPQLKSHV
     GKLRASESPS TVFFYKDGKR KGTPKSFSRS VSRVESFEDR SRPPFMPLPL TKPRSISFPN
     ADTSEYENIP AMSSDYENIQ IPPRRSTRAG TFTEFFEDPS RALSAANEND GYVDMSSFTG
     FENKQQTTDQ ETESAYTEPY KVCPVSVIPA EVITSDEEQR SSEDEKSSQG DPSLINKKEG
     QPRASLIAQE LMSSEKAYVE MLQLLRMDLY EGILKALGEE DEQEVVELKQ GLSELPEMYE
     LHQEILGELE ERVLKWEEHQ KVADVFLSRK SRLNHHTAYI TQFDKNLALL DETCLKYSQL
     ATVIQEFEKS SGGSPQNVKH QLLKVVQRVF QYRVMLTDYL NNLCPDSTEY EATQAALFIV
     SEIADRANES MLQGENLQKL VHIEHSVRGQ SGLLQPGRIF VKEGTLMKVS GKNRHPRHLF
     LMNDVLLYTY PQKDGKYQLK NTLVVSDMKV SRPVTEKAPN VLKIECDEYC LTLSASSCLE
     RDDWYSCISR HIPDDCKAHN TSTCHSNVEL RERLGIPLGE RPPTLVPVSH VMMCMNCGCD
     FTLTLRRHHC HACGKIVCRN CSRNKYPMKY LRDQAAKVCD SCYVELKKRE RPLSVSFPPT
     SSRCSSSAFS SVFHNIHYSS FKKQKKIPSA LTEVAASGEG ATISGYLTRC KRGKRHWKKR
     WFVIKGKVLY TYIANEDKVA TESLPLLGFT VAPEKEEGCI DTVFHLYHKQ TLFYSFRADD
     NYSAQRWIEA MEEASIL
//