ID E1C2Q6_CHICK Unreviewed; 926 AA.
AC E1C2Q6; A0A2H4I795;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 4.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=G protein-coupled receptor 133 variant X1 {ECO:0000313|EMBL:ART34151.1};
GN Name=GPR133 {ECO:0000313|EMBL:ART34151.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:ART34151.1};
RN [1] {ECO:0000313|EMBL:ART34151.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Hypothalamus {ECO:0000313|EMBL:ART34151.1};
RA Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K., Barbian K.,
RA Babar A., Rosenke K.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KX163097; ART34151.1; -; mRNA.
DR AlphaFoldDB; E1C2Q6; -.
DR STRING; 9031.ENSGALP00000004032; -.
DR PaxDb; 9031-ENSGALP00000004032; -.
DR VEuPathDB; HostDB:geneid_416803; -.
DR eggNOG; KOG4193; Eukaryota.
DR HOGENOM; CLU_008509_0_0_1; -.
DR InParanoid; E1C2Q6; -.
DR Bgee; ENSGALG00000002557; Expressed in heart and 5 other cell types or tissues.
DR ExpressionAtlas; E1C2Q6; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15256; 7tmB2_GPR133; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF216; ADHESION G-PROTEIN COUPLED RECEPTOR D1; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|EMBL:ART34151.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 618..862
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 926 AA; 103618 MW; CAD67A086E8250DD CRC64;
MIENLQEFDL GCTSNLTLTM KNLLSLLCCR YSLLILFQFK YQVYGNYSQL LEHPGFKVFS
SASHYWPLED VDGIHEFRDT NGALRIHNFT VLPSHNSTFV YTNDSAYSNF SATVDIVEGM
VNKGIYVTEK KGVTFLFFGR YQNSCISNPE VCGPEGVTFS FFWKTQDQQT KFPPASGGQV
ISSGFKICSS EGEGSVEFYT RGNAMMKWKA SFSPPGPYWT HILFTWKSRE GLKVYVNGTL
NTTDPDGKVF YDYGDPSANL LTGTEGDQTK RYVNGAFDEF IIWERALTPN EIEQYFTAAI
GVQFLLSSTL SWSTMTTTTK PVLSTNAYHP IITNLTKERG NFHSSDILLE YLENVSFSLP
NKSLSENTAL SLTEAFLKVI EDFLLLPNWL EIPETAHIFG SLIQTIDSVM VHMTRNLEEN
SLSLTVEGSS SVADYTLAKM HPKTLNLSHY RFPSRGQSFI SIPSEAFQER AWITIVGMFY
HNMHYYFHSI NPMDTKIAEA AAYKGYMISA ASYLISIKVD PPPKLSHNLS GSPLITIQLT
HRLTPRQYSL ALNKSNRVHL YCAFLDYSNG TGVWSNEGCV RESGDLNYSV CLCNHLTNFA
ILMQVVPLKL TREHQVALSS ITYIGCALSI FCLTITLVTF AVLSSVSTIR NQRYHIHANL
SFAVLVAQIL LVTSFQFSPG TVPCKILAIL LHFFFLSAFA WMLVEGFHLY SMVIKVFGSE
ESKHLYYYGI GWGCPLVICV ISATSSLDSY GESDNCWLSL ENGAIWAFVA PALFVILVNI
GILIAVTRVI SRISADNYKV HGDANAFKLT AKAVAVLLPI LGSSWIFGIL AINAHTLIFQ
YMFAVFNSLQ GFFMFLFHCL LNSEVRAAFK HKTKVWSLTS SSARNINVKP FNSDIMSGNR
PGTTPTKLNT WDKSTNSANR IDLSAV
//