ID E1EYY4_GIAIA Unreviewed; 487 AA.
AC E1EYY4;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Nucleoside transporter {ECO:0000313|EMBL:EFO64617.1};
GN ORFNames=GLP15_2996 {ECO:0000313|EMBL:EFO64617.1};
OS Giardia intestinalis (strain P15) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO64617.1, ECO:0000313|Proteomes:UP000008974};
RN [1] {ECO:0000313|EMBL:EFO64617.1, ECO:0000313|Proteomes:UP000008974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P15 {ECO:0000313|EMBL:EFO64617.1,
RC ECO:0000313|Proteomes:UP000008974};
RX PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA Andersson J.O., Svard S.G., Andersson B.;
RT "Genome analysis and comparative genomics of a Giardia intestinalis
RT assemblage E isolate.";
RL BMC Genomics 11:543-543(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO64617.1}.
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DR EMBL; ACVC01000076; EFO64617.1; -; Genomic_DNA.
DR AlphaFoldDB; E1EYY4; -.
DR STRING; 658858.E1EYY4; -.
DR EnsemblProtists; EFO64617; EFO64617; GLP15_2996.
DR VEuPathDB; GiardiaDB:GLP15_2996; -.
DR OMA; ARGMNEF; -.
DR OrthoDB; 517168at2759; -.
DR Proteomes; UP000008974; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF90; NUCLEOSIDE TRANSPORTER FUN26; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR PRINTS; PR01130; DERENTRNSPRT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 33..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 53690 MW; 34BE6EDA112C4AF2 CRC64;
MDIKQDMKDS AIPQGGGSKT ESKTEPKKGC NCTLLYVMFL MFGVGSLLPF NCYITPYEYM
TRFYPKSVLS FFSLSYNVGN WGMMFIYLKV GKKLPARMSN IVIFIVWIIC LTILPCLAFI
DMNVIVRFVI AIILVFISGV LNGICFPKIV SVGSRISFDL VQAMMSGNGV AGIITAALYA
ITKGIAVASS NGIFTDDQLK YGTLSYFILS DLILLICIFC WIKVMKDYPH LNYDEDPAEE
VKMEPSIINT SSAQPDCNAS NVMPQGSASL GNETIDQSVL PLGNLLNPKT GKKYTFMQLV
RILLVPGLGV FFVFFVTLAF FPSITGKIPY VDGVNKNIND NGWWSVGMTS LFMIFDYVGR
SLPQIEVLTR IRTTPLLIFS LLRIVFGVLF LLMGIPIPTY SGNSISKINA PIQNDYVSTI
TMILFALTNG YVSTVVMIRY GDHVPHPSYM AASGDIMSFW LNTGLIAGGL VSLFIDLGMD
PTSLNVS
//
