ID E1EZE2_GIAIA Unreviewed; 1382 AA.
AC E1EZE2;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:EFO64400.1};
GN ORFNames=GLP15_936 {ECO:0000313|EMBL:EFO64400.1};
OS Giardia intestinalis (strain P15) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO64400.1, ECO:0000313|Proteomes:UP000008974};
RN [1] {ECO:0000313|EMBL:EFO64400.1, ECO:0000313|Proteomes:UP000008974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P15 {ECO:0000313|EMBL:EFO64400.1,
RC ECO:0000313|Proteomes:UP000008974};
RX PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA Andersson J.O., Svard S.G., Andersson B.;
RT "Genome analysis and comparative genomics of a Giardia intestinalis
RT assemblage E isolate.";
RL BMC Genomics 11:543-543(2010).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO64400.1}.
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DR EMBL; ACVC01000096; EFO64400.1; -; Genomic_DNA.
DR STRING; 658858.E1EZE2; -.
DR EnsemblProtists; EFO64400; EFO64400; GLP15_936.
DR VEuPathDB; GiardiaDB:GLP15_936; -.
DR OMA; CEWARNI; -.
DR OrthoDB; 312149at2759; -.
DR Proteomes; UP000008974; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 451..602
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 725..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1076..1113
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1306..1340
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1382 AA; 156339 MW; 1BD7A898A8C3F164 CRC64;
MSSFNLEEIF RQEEKVLCRA LRDSNIPKIV AEDTEIFLGL IGDLFPSVDV PRLQDKNFEA
LIKKSLLAQR LQAEDSFILK IVQFEELLQI RHSVFILGSC AVGKTKCWTT LAETYKLQNK
KIQYQVISPK SITTRELYGY IHPASREWKD GIFSTIMRDL VAIPNTEPKW IVLDGDIDAL
WVESLNTVMD DNKILTLASN ERIPLMPYMR LVFEIGDLKY ASPATVSRAG IIYINETDVG
WLAYSASWVE LRESSLERST LTVLFEKYVP PVLEAMRKQL KTVTPVADMS VVQTICRLLD
ALLSEYYASP GCKVNTANAA LIQQQGSSGG AQGEGGKIVD YFKDILEYFF IFATIWASGG
TMFKDQLTDH RKQFTKFWKT EFSKGITFPA IGEVFDYYVA INDETGEPRW QTWDDRLTPY
VHDDEALPSQ VHVETIETYR LHYMLERLVK NGHPVLFCGP AGSGKTSLLK SMVGSLNDQE
YGSASIALNY YTTSMLLQTI MESYLEKKVG RRYGPVGNRK LIYIIDDLNM PQVDTYGTQQ
PLTLIRLHRD YLFWFDREKL TIKEITNCQY LASMNPYSGS FSVDPRLQWH FSTFSVDFPS
DENLKQIYGS LLRGHFTREE AGFPHGVSKA WEAITNALLK IHSKVSSSFL PTAIKFHYMF
NLRDLTNITE GLMRATRDTI KTTPQLIQLL VHECARVYCD RMVTIEDKEA YSKLVEEVVM
ADLQNITPPK DPNEEATAKG RPKSQPGGVM ASQPIAVDMK DVFQRDEESN ALPIIFSNFA
LGVGDGRYGQ IPDYDKLYPL LRDALEQHNE VNAVMDLVLF RDAMEHVCRI SRIITTGDAL
LVGVGGSGKQ SLAKLAAYIN SYEVFQITIS STYDIPDFRA DLQQLYIKTG LKGIPTMFLF
TDTQIVNEEF CVYINDLLSS GNICGLFPPE EEENIINGVR SEAKSAGIPE TRENLYNYFI
SKVKQNLHVV LGFSPIGEAF RVRARKFPAL VTCTTIDWFQ AWPHEALVSV GKRFLGELEM
SPELKDSVAL FMADANGLVN QMSVAYDQVE RRKAYTTPKS FLELISLYIK LLHGRRREIY
DQIERLEQGN TKLEKTEEDV SELKKALVEQ QKIVDERKKA ADELLEVVEK DAAFVGERQQ
EAMVEAEKTA EVEKEVTAKE EVARLELGKA EPAIEAAQAA LNTLNKNNLV ELRSFASPSA
EIVNVMGAVM CLLDTPGKLP KDRSWKAAKN VMGSIDTFLN RLQNYDKDNI HEVNFAAAKK
YTSDPNFTGE FIRSKSVAAA GICEWARNIV SYNEIYKIVL PLREAAAEAA MQLEAARKKY
KAVMDNVAKL NKKLQTLKDQ FDKGMLLGET LLMCVCLYVS RSGAPLLNYQ RIRLQTSEKS
TR
//
