ID   E1F988_GIAIA            Unreviewed;       713 AA.
AC   E1F988;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Kinase, NEK {ECO:0000313|EMBL:EFO60975.1};
GN   ORFNames=GLP15_3285 {ECO:0000313|EMBL:EFO60975.1};
OS   Giardia intestinalis (strain P15) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO60975.1, ECO:0000313|Proteomes:UP000008974};
RN   [1] {ECO:0000313|EMBL:EFO60975.1, ECO:0000313|Proteomes:UP000008974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P15 {ECO:0000313|EMBL:EFO60975.1,
RC   ECO:0000313|Proteomes:UP000008974};
RX   PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA   Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA   Andersson J.O., Svard S.G., Andersson B.;
RT   "Genome analysis and comparative genomics of a Giardia intestinalis
RT   assemblage E isolate.";
RL   BMC Genomics 11:543-543(2010).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFO60975.1}.
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DR   EMBL; ACVC01000464; EFO60975.1; -; Genomic_DNA.
DR   AlphaFoldDB; E1F988; -.
DR   STRING; 658858.E1F988; -.
DR   EnsemblProtists; EFO60975; EFO60975; GLP15_3285.
DR   VEuPathDB; GiardiaDB:GLP15_3285; -.
DR   OMA; QNRHVDC; -.
DR   OrthoDB; 5478903at2759; -.
DR   Proteomes; UP000008974; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR   PANTHER; PTHR24120; GH07239P; 1.
DR   Pfam; PF12796; Ank_2; 3.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00248; ANK; 8.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:EFO60975.1};
KW   Transferase {ECO:0000313|EMBL:EFO60975.1}.
FT   DOMAIN          58..314
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   COILED          325..359
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   713 AA;  78752 MW;  25D9ACF752FB802E CRC64;
     MSTVKLKLMM GIDCMLHPSA SVAAKNLLGL ASNDEVSGLA ESRGTGDIPM FSPKTLREHL
     GSVLSRRTRS TVYSLKGYPH LAVREIKLNS LDQYGVDAAK LELFAFPHTS YPEVLSCGRI
     IRDRNTAFII MDRHCGDLQQ LIANYRETHK PIPKRLVLSL IRELANCLVY LHDPINGVYG
     SLFPGVILRP DNILFTENKK HIILLDFELC RSMSSWTTNV GDPVYTAPET LLYNETGPAS
     HVWSLGAIAY ELATLRKPDF LGGRELAEVS VDEWRPDLSS VTDDLIRGIL EKILVPDPER
     RPTARGLVRL LQMFDASPDR QEAQDTALRD RCASLEAALN DANNKILSLE RELAAKSAGT
     DVPKEQFTET PETLEKVKEI SMKTDIRDAW DLTDTTDITD TTDITDTTDT VDAIDTTDET
     DNIEDTEEEH LEEDDSTDLM RAVDRNDVEA VKALVPLQGG MQMKGCARVN NWKIYGGTAL
     MKAAVYGYAE IVELLMEKEG GMRDNSGWTA LIWAARTGHV DCLELLLEKE GGMRDNKGGT
     ALMATVGNGY SDCAKRLLRK EIGMQDNNGF TALMAAACRG YVDCVKLLMG KESRMQDGGG
     WTALMCAADI GRPDCVELLV EKEGGMQRSD GMTALMWAAQ NRHVDCVKLL VDKESGMRDK
     KGRTALILAV QAGSVDCVKL LMREKNLRDT TGKSALNIAV ICGYYEIIAL LSK
//