ID E1IDX6_9CHLR Unreviewed; 996 AA.
AC E1IDX6;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=OSCT_1527 {ECO:0000313|EMBL:EFO80587.1};
OS Oscillochloris trichoides DG-6.
OC Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Chloroflexineae;
OC Oscillochloridaceae; Oscillochloris.
OX NCBI_TaxID=765420 {ECO:0000313|EMBL:EFO80587.1, ECO:0000313|Proteomes:UP000054010};
RN [1] {ECO:0000313|EMBL:EFO80587.1, ECO:0000313|Proteomes:UP000054010}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DG-6 {ECO:0000313|EMBL:EFO80587.1,
RC ECO:0000313|Proteomes:UP000054010};
RX PubMed=21037015; DOI=10.1128/JB.00931-10;
RA Kuznetsov B.B., Ivanovsky R.N., Keppen O.I., Sukhacheva M.V.,
RA Bumazhkin B.K., Patutina E.O., Beletsky A.V., Mardanov A.V., Baslerov R.V.,
RA Panteleeva A.N., Kolganova T.V., Ravin N.V., Skryabin K.G.;
RT "Draft genome sequence of the anoxygenic filamentous phototrophic bacterium
RT Oscillochloris trichoides subsp. DG-6.";
RL J. Bacteriol. 193:321-322(2011).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO80587.1}.
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DR EMBL; ADVR01000048; EFO80587.1; -; Genomic_DNA.
DR RefSeq; WP_006562087.1; NZ_GL501404.1.
DR AlphaFoldDB; E1IDX6; -.
DR STRING; 765420.OSCT_1527; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_0; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000054010; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000054010}.
FT DOMAIN 816..832
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 469..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 742..749
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 996 AA; 111027 MW; 739F6FE82B33C464 CRC64;
MAKVEIHQWY RQYRKLKAEA EDAILLFRFG DFYETFDDDA KLIAELLDVT LTRKDFAVDK
GRPKEEQKLF TPMAGMPYHA VERYVNDLVA RGYRVAIAEQ LSETEASRSD TRPKSIFAAG
LQQIVPGEME RKMVHREIVR VITPGTVVDP SMLTATSNTY LAAAITEGGQ IGLAYAELST
GEFAAIEFSG ERAAAQLQGE LARLQVAEVL VPDDPHLRVA DLAPAEARLT QDLAPLTKDE
RDLLLPHERV ARRLDQDSEA RWTKGHVTAW PSWRWDIQTA QETLTRQLRV QSLAAFGLDG
RPLATRAAGA LLQYVHQTQR HQANQINRLR VYTTSSFMFL DPQTRRNLEL LESSSATSKT
ALIHILDRTR TPMGARLLRR WLNQPLLELE PLLARQEAIA ACVEATLLRA ELRQALGQVG
DMERAVNRVA QGVTVATPRD MVQLRTALRA LPEIITATGT ELTAMIPEPS RAMPPAGSQP
AQPAEEEEED LFAADAPSAE AETEAPHLLD ACNDIAALLE RALDDDPPAL LGSSNYLRGG
EEGGERPRRV LRPGFEPRID ALVRASRHAQ EFIDRLEGRE RDRTGIRSLK VGYNSVFGYY
IEVSRTTDEK LIPKDYQRKQ TLVGAERYVT EELKEYEQVI DRAKLQLVEM EREAFARLCE
EIGQHTERLR EVARILAQLD VVAALAEVAV RGRYTRPSLN TSTRLQIRGG RHPVVEQMIP
ETFVPNDILI DTTSAQMLII TGPNMSGKST VMRQVALIVL LAQIGAFVPA ESAEVGLVDR
IFTRIGAQDD IATGQSTFMV EMTETAALLV QSSRRSLIIL DEVGRGTSTY DGMAIARAVV
EYIHNEPQLQ CRTLFATHYH ELTALEHELD RVRNLHMAAI EQGKHVVFLH QLREGGADRS
YGIHVAELAG IPRPVIQRAS ELLAELEAGR SAAPIPVPPP TPTLTPPPRE GQLSLFDLAP
NPVIEYLRRL KINDLTPLEA LNRLAELQRL AEKAVS
//
