ID E1IUR4_ECOLX Unreviewed; 774 AA.
AC E1IUR4;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Nucleoside triphosphatase, D5 family {ECO:0000313|EMBL:EFO56983.1};
DE EC=3.6.1.15 {ECO:0000313|EMBL:EFO56983.1};
GN ORFNames=HMPREF9348_03937 {ECO:0000313|EMBL:EFO56983.1};
OS Escherichia coli MS 145-7.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=679204 {ECO:0000313|EMBL:EFO56983.1, ECO:0000313|Proteomes:UP000003691};
RN [1] {ECO:0000313|EMBL:EFO56983.1, ECO:0000313|Proteomes:UP000003691}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS 145-7 {ECO:0000313|EMBL:EFO56983.1,
RC ECO:0000313|Proteomes:UP000003691};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO56983.1}.
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DR EMBL; ADWS01000024; EFO56983.1; -; Genomic_DNA.
DR AlphaFoldDB; E1IUR4; -.
DR Proteomes; UP000003691; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003896; F:DNA primase activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0017111; F:ribonucleoside triphosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01029; TOPRIM_primases; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 3.90.580.10; Zinc finger, CHC2-type domain; 1.
DR InterPro; IPR004968; DNA_primase/NTPase_C.
DR InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR InterPro; IPR045455; NrS-1_pol-like_helicase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014818; Phage/plasmid_primase_P4_C.
DR InterPro; IPR013237; Phage_T7_Gp4_N.
DR InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35372; ATP BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR35372:SF2; SF3 HELICASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08706; D5_N; 1.
DR Pfam; PF19263; DUF5906; 1.
DR Pfam; PF03288; Pox_D5; 1.
DR Pfam; PF08273; Prim_Zn_Ribbon; 1.
DR Pfam; PF13362; Toprim_3; 1.
DR SMART; SM00885; D5_N; 1.
DR SMART; SM00778; Prim_Zn_Ribbon; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51206; SF3_HELICASE_1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EFO56983.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Primosome {ECO:0000256|ARBA:ARBA00022515};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 471..624
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51206"
SQ SEQUENCE 774 AA; 84988 MW; 041209B2ED34CCFC CRC64;
MKVSQAVKAA RGHWAQILPA LGVNILKNRH QPCPVCGGKD RFRFDDQEGR GTWFCNQCGA
GDGLALVTRA LNVDISEAAD RIHGLTHGLF IANSEVRTLT ADTDSGKDAA AALAARLLQA
SRESAGNTYL THKGFPEHVC HELTSAHKTG GVMFRPGDLI VPLYNADGEL VNIQLISGNG
SKCFLKGGQV KEAYHLIEGG GSSVRRVWIA EGYATALTIH HLTGEAVMVA FSSVNFLSLA
SVAHNKYPGY QLIIAADRDL NGSGQNRAEA AAKACQCDIV LPPVFGDWND ALAHYGEEST
RKAILEALKP HNASPFDTMS EAEFTAMSVS EKAQRVREHY RDALAVDPNG QLLSRYESGA
WKVISQSDFA RDVAALFQRL GAPFSSGKIA SLVETLKLIV PQQQNPARHL IGFRNGVLDT
RTGLFSPHCK ENWLRTVCEV DFTPPVKGET LETHAPAFWR WLDRAAGHKP AKRDIILAAL
FMVLANRYDW QLFLEVTGPG GSGKSILAEI ATMLAGEDNA TSATIETLES PRERAALIGF
SLIRLPDQEK WSGDGAGLKA ITGGDAVSVD PKYQNAYSTH IPAVILAVNN NPMRFTDRSG
GVSRRRVILH FPEQIAPEER DPQLKDKIAR ELAVIVRQLM QRFSDPMSAR TLLQSQQNSD
EALTIKRDAD PAFDFCGYLE ALPDTNGMFM GNANIVPRQP RTYLYHAYLV YMEANGYKNT
LSLTMFGKGL PLMLKEYGLQ YEKRRTNQGM QTNLALREEC NADWLPKCSL EITK
//
