ID   E1J8R5_ECOLX            Unreviewed;       707 AA.
AC   E1J8R5;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   SubName: Full=Anaerobic ribonucleoside-triphosphate reductase {ECO:0000313|EMBL:EFK67823.1};
DE            EC=1.17.4.2 {ECO:0000313|EMBL:EFK67823.1};
GN   Name=nrdD {ECO:0000313|EMBL:EFK67823.1};
GN   ORFNames=HMPREF9347_03322 {ECO:0000313|EMBL:EFK67823.1};
OS   Escherichia coli MS 124-1.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=679205 {ECO:0000313|EMBL:EFK67823.1, ECO:0000313|Proteomes:UP000003390};
RN   [1] {ECO:0000313|EMBL:EFK67823.1, ECO:0000313|Proteomes:UP000003390}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MS 124-1 {ECO:0000313|EMBL:EFK67823.1,
RC   ECO:0000313|Proteomes:UP000003390};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFK67823.1}.
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DR   EMBL; ADWT01000028; EFK67823.1; -; Genomic_DNA.
DR   AlphaFoldDB; E1J8R5; -.
DR   Proteomes; UP000003390; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008998; F:ribonucleoside-triphosphate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd01675; RNR_III; 1.
DR   Gene3D; 3.20.70.20; -; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR019777; Form_AcTrfase_GR_CS.
DR   InterPro; IPR001150; Gly_radical.
DR   InterPro; IPR012833; NrdD.
DR   NCBIfam; TIGR02487; NrdD; 1.
DR   PANTHER; PTHR21075; ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE; 1.
DR   PANTHER; PTHR21075:SF0; ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   Pfam; PF13597; NRDD; 1.
DR   SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
DR   PROSITE; PS00850; GLY_RADICAL_1; 1.
DR   PROSITE; PS51149; GLY_RADICAL_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00492};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00492};
KW   Organic radical {ECO:0000256|ARBA:ARBA00022818, ECO:0000256|PROSITE-
KW   ProRule:PRU00493}; Oxidoreductase {ECO:0000313|EMBL:EFK67823.1}.
FT   DOMAIN          1..87
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000259|PROSITE:PS51161"
FT   DOMAIN          578..703
FT                   /note="Glycine radical"
FT                   /evidence="ECO:0000259|PROSITE:PS51149"
FT   MOD_RES         676
FT                   /note="Glycine radical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00493"
SQ   SEQUENCE   707 AA;  79457 MW;  129366E17765B73C CRC64;
     MKRDGCKVPF KSERIKEAIL RAAKAAEVDD ADYCATVAAV VSEQMQGRNQ VDINEIQTAV
     ENQLMSGPYK QLARAYIEYR HDRDIEREKR GRLNQEIRGL VEQTNASLLN ENANKDSKVI
     PTQRDLLAGI VAKHYARQHL LPRDVVQAHE RGDIHYHDLD YSPFFPMFNC MLIDLKGMLT
     QGFKMGNAEI EPPKSISTAT AVTAQIIAQV ASHIYGGTTI NRIDEVLAPF VTASYNKHRK
     TAEEWNIPDA EGYANSRTIK ECYDAFQSLE YEVNTLHTAN GQTPFVTFGF GLGTSWESRL
     IQESILRNRI AGLGKNRKTA VFPKLVFAIR DGLNHKKGDP NYDIKQLALE CASKRMYPDI
     LNYDQVVKVT GSFKTPMGCR SFLGVWENEN GEQIHDGRNN LGVISLNLPR IALEAKGDEA
     TFWKLLDERL VLARKALMTR IARLEGVKAR VAPILYMEGA CGVRLNADDD VSEIFKNGRA
     SISLGYIGIH ETINALFGGE HVYDNEQLRA KGIAIVERLR QAVDQWKEET GYGFSLYSTP
     SENLCDRFCR LDTAEFGVVP GVTDKGYYTN SFHLDVEKKV NPYDKIDFEA PYPPLANGGF
     ICYGEYPNIQ HNLKALEDVW DYSYQHVPYY GTNTPIDECY ECGFTGEFEC TSKGFTCPKC
     GNHDASRVSV TRRVCGYLGS PDARPFNAGK QEEVKRRVKH LGNGQIG
//