ID E1LL80_STRMT Unreviewed; 171 AA.
AC E1LL80;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Galactose-6-phosphate isomerase subunit LacB {ECO:0000256|HAMAP-Rule:MF_01556};
DE EC=5.3.1.26 {ECO:0000256|HAMAP-Rule:MF_01556};
GN Name=lacB {ECO:0000256|HAMAP-Rule:MF_01556,
GN ECO:0000313|EMBL:EFN99063.1};
GN ORFNames=SMSK564_0607 {ECO:0000313|EMBL:EFN99063.1};
OS Streptococcus mitis SK564.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=585203 {ECO:0000313|EMBL:EFN99063.1, ECO:0000313|Proteomes:UP000004966};
RN [1] {ECO:0000313|EMBL:EFN99063.1, ECO:0000313|Proteomes:UP000004966}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK564 {ECO:0000313|EMBL:EFN99063.1,
RC ECO:0000313|Proteomes:UP000004966};
RA Daugherty S.C., Tallon L.J., Jones K.M., Liu X., Kilian M., Tettelin H.;
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_01556};
CC -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC {ECO:0000256|HAMAP-Rule:MF_01556}.
CC -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC {ECO:0000256|HAMAP-Rule:MF_01556}.
CC -!- SIMILARITY: Belongs to the LacAB/RpiB family.
CC {ECO:0000256|ARBA:ARBA00008754, ECO:0000256|HAMAP-Rule:MF_01556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFN99063.1}.
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DR EMBL; AEDU01000008; EFN99063.1; -; Genomic_DNA.
DR RefSeq; WP_001216913.1; NZ_AEDU01000008.1.
DR AlphaFoldDB; E1LL80; -.
DR eggNOG; COG0698; Bacteria.
DR UniPathway; UPA00702; UER00714.
DR Proteomes; UP000004966; Unassembled WGS sequence.
DR GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1400.10; Sugar-phosphate isomerase, RpiB/LacA/LacB; 1.
DR HAMAP; MF_01556; LacB; 1.
DR InterPro; IPR004784; LacB.
DR InterPro; IPR003500; RpiB_LacA_LacB.
DR InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR NCBIfam; TIGR01119; lacB; 1.
DR NCBIfam; TIGR00689; rpiB_lacA_lacB; 1.
DR PANTHER; PTHR30345:SF0; DNA DAMAGE-REPAIR_TOLERATION PROTEIN DRT102; 1.
DR PANTHER; PTHR30345; RIBOSE-5-PHOSPHATE ISOMERASE B; 1.
DR Pfam; PF02502; LacAB_rpiB; 1.
DR PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR SUPFAM; SSF89623; Ribose/Galactose isomerase RpiB/AlsB; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|HAMAP-Rule:MF_01556, ECO:0000313|EMBL:EFN99063.1};
KW Lactose metabolism {ECO:0000256|ARBA:ARBA00022736, ECO:0000256|HAMAP-
KW Rule:MF_01556}.
SQ SEQUENCE 171 AA; 18943 MW; 4134A76CE7C72C39 CRC64;
MRIAIGCDHI VTDEKMAVSE FLKSKGYEVI DFGTYDHTRT HYPIFGKKVG EAVTSGQADL
GVCICGTGVG INNAVNKVPG VRSALVRDMT TALYAKEQLN ANVIGFGGKI TGELLMCDII
EAFIHAEYKP SEENKKLIAK IEHVESHNAQ QTDANFFTEF LEKWDRGEYH D
//
