ID E1MBX8_9ACTO Unreviewed; 1213 AA.
AC E1MBX8;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=HMPREF9278_0019 {ECO:0000313|EMBL:EFN94019.1};
OS Mobiluncus mulieris FB024-16.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Mobiluncus.
OX NCBI_TaxID=866770 {ECO:0000313|EMBL:EFN94019.1, ECO:0000313|Proteomes:UP000004387};
RN [1] {ECO:0000313|EMBL:EFN94019.1, ECO:0000313|Proteomes:UP000004387}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FB024-16 {ECO:0000313|EMBL:EFN94019.1,
RC ECO:0000313|Proteomes:UP000004387};
RA Durkin A.S., Madupu R., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFN94019.1}.
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DR EMBL; AEGV01000008; EFN94019.1; -; Genomic_DNA.
DR RefSeq; WP_004017456.1; NZ_AEGV01000008.1.
DR AlphaFoldDB; E1MBX8; -.
DR Proteomes; UP000004387; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 21..437
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 438..743
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1213 AA; 136191 MW; 0C3617F15F035703 CRC64;
MRKTSIEILN PEHLALLTKA FPPTEEQEQV IKAPLEPLLV VAGAGSGKTE TIANRLVYWV
VNGAISPQSV LGLTFTKKAT AEMGQRFALR LDNLAQNLEK FVASPSRFEV EMCRQLKGDW
QWRDDSKIHG FIRSLTAGLH ALRESGMTSR ILRSGVEVST YDALASKVLT EFGVLAGRDS
GYQTITDGTR FQIMSQILET WVSNLSYREE EGASVGNFIE GLLHLAGDVN AHVVDLNTMK
KLYADFLATA QRELLASQKL DEALEPLKAA KKAAKAANDK QREKALGAEI TNLDLPLTSQ
AKKDLERTVE VMRFGVDAVE VIRAFNTRKA QLRFADFSDQ TREVVELLKK VANISQSYQQ
RYQLVLLDEF QDTSVAQLKY LSALFRNHAV TAVGDPNQAI YAWRGASAAS IEEFPKYFSD
NPSKVASLTL RTSWRNDAAI LNVANCIASE IAEQNRTEGK NENFIMPDLS LRPGASPDLG
RVYGAPFLTD TDEAQAVANF LENWRKDLEQ AVEKTAAWQA AGRVGQPPSL PTAAVLCRKK
SIMLPILREL SRRGIPFQLQ ARESALLDPG VVLVRAALNV VVNPQNSGSL LLLLNRFRLS
REDLEAISKA AGRTVLPFQE VMKSQIGASV SQPGRERLAI LREIIAKLEK HVSYATPLQM
AKLAAKLLGL DIEQRIPGTP YQEEAFTIFL SIIEDFERSG QATLRAFLEW LDVAESEEKE
VGQFQEAVDT KKVQVITVHA AKGLEWDYVA VPGLSEGNFP DNRTEIWLKN YFVLPYPLRG
DRDSLPQYEI NLRQLGEKDR SRKFLEQYDG VRTLHHLKEE ANLAYVAFTR AKSHLFLSMS
WFKGCNVNTA KPGAFFRVLL GEDAKLFCME KPNKGMTLVN SQEFMHLPDW LGDINPCFTE
PEEANPNVQE FEAGLWQAPS WLDLPPESIR PETFPWDVAG LQRSYQMVTV AAENPPDSQA
LESAIPGSLS WRVWKLYNAP RPRLDSSMLL RQIAATSVVK LDESSDDFML QKLRPLPLPP
SPAARLGIIM HAWIAQQLGQ PTLDIPDGSE ATLDADSRLK LDCYRQTWEN LQFLKGKAVM
DIEHSGSLVV GEGTEGFEVP LRIDAVFQER SCGTTWIVDW KTASHPNPPQ YERYLHQLGI
YRLYWLQTHP ELDSQDIQCA YVYLKEGETE HQVLTLESIL EHLKMPDYTP EYLYKLLKRG
ETEATEFLSQ KNL
//
