ID E1PY73_HELPM Unreviewed; 459 AA.
AC E1PY73;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Type III R-M system modification enzyme {ECO:0000313|EMBL:ADO03108.1};
GN OrderedLocusNames=HPSJM_07770 {ECO:0000313|EMBL:ADO03108.1};
OS Helicobacter pylori (strain SJM180).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=765962 {ECO:0000313|EMBL:ADO03108.1, ECO:0000313|Proteomes:UP000006862};
RN [1] {ECO:0000313|Proteomes:UP000006862}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SJM180 {ECO:0000313|Proteomes:UP000006862};
RA Kersulyte D., Velapatino B., Gilman R.H., Berg D.E.;
RT "Complete genome sequence of Helicobacter pylori strain SJM180.";
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002073; ADO03108.1; -; Genomic_DNA.
DR RefSeq; WP_013356482.1; NC_014560.1.
DR AlphaFoldDB; E1PY73; -.
DR REBASE; 28234; M.Hpy180ORF7765P.
DR KEGG; hpm:HPSJM_07770; -.
DR HOGENOM; CLU_020164_2_2_7; -.
DR Proteomes; UP000006862; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR002295; N4/N6-MTase_EcoPI_Mod-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF16; TYPE III RESTRICTION-MODIFICATION ENZYME STYLTI MOD SUBUNIT; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PIRSF; PIRSF015855; TypeIII_Mtase_mKpnI; 1.
DR PRINTS; PR00506; D21N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 112..444
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 459 AA; 52933 MW; D8C393BCEF39369C CRC64;
MQNKEIGGEK SVNEKNLEVF NRYFPGCLSI ENDDKLTLDT KKLKALLGDF SEIKEEGYGL
DFVGKKIALN QAFKKNHKIL KPLNKSTSKH ILIKGDNLDA LKILKQSYSE KIKMIYIDPP
YNTKNDNFIY GDDFSQSNEE ILKTLDYSKE KLDYIKNLFG LKSHSGWLSF MYPRLLLAKD
LLKQDGVIFI SIDDNEAAQL KLLCDEIFGE RNFVAEMPRL VKRAGKSTNQ IAKNHDYVLC
YQKNSINFKQ IDIDENDYPF KDEFYNERGG YRLNQALDSN TLGYVKSLDY IIEINGKKYI
AGGLTEYQRL QKVNGRLADN FRWRWSKAKF DFGLANGFVE VKNNRIYTKT YTKAKISDSK
PYKIEYFNRT KNILSVDFID HKYSNDMATK GLQKLFNERN IFDYSKPVEL ISFLIDQTTE
KGDIILDFFA GSGTTAHAVL ESNKSDYQKL SEGGGYLMA
//
