ID E1U2Y6_HAECO Unreviewed; 523 AA.
AC E1U2Y6;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Lgc-53 {ECO:0000313|EMBL:ACJ65067.1};
GN Name=lgc-53 {ECO:0000313|EMBL:ACJ65067.1};
OS Haemonchus contortus (Barber pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6289 {ECO:0000313|EMBL:ACJ65067.1};
RN [1] {ECO:0000313|EMBL:ACJ65067.1}
RP NUCLEOTIDE SEQUENCE.
RA Beech R.N., Rao V., Lian J., Nabhan J., Forrester S.;
RT "Ligand-Gated Ion-Channels of Haemonchus contortus.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; EU879912; ACJ65067.1; -; mRNA.
DR AlphaFoldDB; E1U2Y6; -.
DR SMR; E1U2Y6; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18990; LGIC_ECD_GABAAR; 1.
DR CDD; cd19049; LGIC_TM_anion; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF939; HISTAMINE-GATED CHLORIDE CHANNEL SUBUNIT 1; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 19..523
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5022263054"
FT TRANSMEM 315..337
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 344..360
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 380..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 499..517
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 107..313
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 323..421
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT REGION 51..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 60230 MW; C135107F18FECDA5 CRC64;
MIISYLARIV LLLPDLSASD NDRLINIART SHARLGHVNE VGADGRLNYT ASQRAHEPRT
LSKATSTADL SDDGYEPARS YDRDRSWSSR KPRDDEECIP INDTLRKHLL QELFSDAYDK
NNLPSSNSTE VIVELTVQSI TEISEFSSSF KADVWFPQIW RDPRLDFTDR NYCIKNISLA
AHKLPQLWSP NVCFVNSKKV EIHSSPSQNI LLLVFPNGTI WLNFRVSLIG PCKLDLTYFP
MDRQSCNLIF ESYSYNTAEV RIVWRDWEPV SIPDPNSKNL PDFELVQYEH RNATLVYTAG
LWDQLEVEFT FRRLYGYYVL QAYMPTYLSV FISWIAFWID TKALPARITL GVSSLMALTF
QFGNIVKNLP RVSYVKALDI WMFGCVGFIF LSLVELAVVG FADKLDAKRK RYGRSIEHAV
MRSDSEQQWL SRLQRSHFTE VVDNRSPLTT GGVPLLVAPE GNGNTQRKRS EEKTRQMYVH
VEHPIHVNGE RIDEISAKLF PLMFTAFNIF YWFYYIGMSG GIF
//
