ID   E1V896_HALED            Unreviewed;       189 AA.
AC   E1V896;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=nicotinamidase {ECO:0000256|ARBA:ARBA00039017};
DE            EC=3.5.1.19 {ECO:0000256|ARBA:ARBA00039017};
DE   AltName: Full=Nicotinamide deamidase {ECO:0000256|ARBA:ARBA00043224};
GN   Name=pncA {ECO:0000313|EMBL:CBV43552.1};
GN   OrderedLocusNames=HELO_3668 {ECO:0000313|EMBL:CBV43552.1};
OS   Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198
OS   / 1H9).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=768066 {ECO:0000313|EMBL:CBV43552.1, ECO:0000313|Proteomes:UP000008707};
RN   [1] {ECO:0000313|Proteomes:UP000008707}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9
RC   {ECO:0000313|Proteomes:UP000008707};
RX   PubMed=20849449; DOI=10.1111/j.1462-2920.2010.02336.x;
RA   Schwibbert K., Marin-Sanguino A., Bagyan I., Heidrich G., Lentzen G.,
RA   Seitz H., Rampp M., Schuster S.C., Klenk H.P., Pfeiffer F., Oesterhelt D.,
RA   Kunte H.J.;
RT   "A blueprint of ectoine metabolism from the genome of the industrial
RT   producer Halomonas elongata DSM 2581(T).";
RL   Environ. Microbiol. 13:1973-1994(2011).
CC   -!- PATHWAY: Cofactor biosynthesis; nicotinate biosynthesis; nicotinate
CC       from nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00037900}.
CC   -!- SIMILARITY: Belongs to the isochorismatase family.
CC       {ECO:0000256|ARBA:ARBA00006336}.
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DR   EMBL; FN869568; CBV43552.1; -; Genomic_DNA.
DR   RefSeq; WP_013333424.1; NC_014532.2.
DR   AlphaFoldDB; E1V896; -.
DR   STRING; 768066.HELO_3668; -.
DR   KEGG; hel:HELO_3668; -.
DR   eggNOG; COG1335; Bacteria.
DR   HOGENOM; CLU_068979_13_1_6; -.
DR   OrthoDB; 9791276at2; -.
DR   Proteomes; UP000008707; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008936; F:nicotinamidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019363; P:pyridine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd01011; nicotinamidase; 1.
DR   Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR   InterPro; IPR000868; Isochorismatase-like.
DR   InterPro; IPR036380; Isochorismatase-like_sf.
DR   PANTHER; PTHR11080:SF2; LD05707P; 1.
DR   PANTHER; PTHR11080; PYRAZINAMIDASE/NICOTINAMIDASE; 1.
DR   Pfam; PF00857; Isochorismatase; 1.
DR   SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CBV43552.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642}.
FT   DOMAIN          13..187
FT                   /note="Isochorismatase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00857"
SQ   SEQUENCE   189 AA;  20123 MW;  E810B38280AE09E1 CRC64;
     MSQLTQDYDH RDALLVVDMQ NDFCPGGALA VAGGDALVPG INAEMDAAQR AGALVVASRD
     WHPVDHASFA HRGGPWPVHC VQDTPGAAFH ADLALPETTI RVSKATAFDR DAYSAFDDTG
     LGDYLRERGI ERVTVCGLAL DVCVKATTLD ALREGFATRL LEDLSAAVDP DAIEECRDTL
     ADAGAELCR
//