ID E1ZEV8_CHLVA Unreviewed; 247 AA.
AC E1ZEV8;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Kinetochore protein SPC25 {ECO:0000256|RuleBase:RU367150};
GN ORFNames=CHLNCDRAFT_52384 {ECO:0000313|EMBL:EFN55565.1};
OS Chlorella variabilis (Green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Chlorellales; Chlorellaceae; Chlorella clade; Chlorella.
OX NCBI_TaxID=554065 {ECO:0000313|Proteomes:UP000008141};
RN [1] {ECO:0000313|EMBL:EFN55565.1, ECO:0000313|Proteomes:UP000008141}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NC64A {ECO:0000313|EMBL:EFN55565.1,
RC ECO:0000313|Proteomes:UP000008141};
RX PubMed=20852019; DOI=10.1105/tpc.110.076406;
RA Blanc G., Duncan G., Agarkova I., Borodovsky M., Gurnon J., Kuo A.,
RA Lindquist E., Lucas S., Pangilinan J., Polle J., Salamov A., Terry A.,
RA Yamada T., Dunigan D.D., Grigoriev I.V., Claverie J.M., Van Etten J.L.;
RT "The Chlorella variabilis NC64A genome reveals adaptation to
RT photosymbiosis, coevolution with viruses, and cryptic sex.";
RL Plant Cell 22:2943-2955(2010).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|RuleBase:RU367150}.
CC -!- SUBUNIT: Component of the NDC80 complex.
CC {ECO:0000256|RuleBase:RU367150}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367150}.
CC Chromosome, centromere, kinetochore {ECO:0000256|RuleBase:RU367150}.
CC -!- SIMILARITY: Belongs to the SPC25 family.
CC {ECO:0000256|ARBA:ARBA00006379, ECO:0000256|RuleBase:RU367150}.
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DR EMBL; GL433844; EFN55565.1; -; Genomic_DNA.
DR RefSeq; XP_005847667.1; XM_005847605.1.
DR AlphaFoldDB; E1ZEV8; -.
DR STRING; 554065.E1ZEV8; -.
DR GeneID; 17354896; -.
DR KEGG; cvr:CHLNCDRAFT_52384; -.
DR eggNOG; KOG4657; Eukaryota.
DR InParanoid; E1ZEV8; -.
DR OMA; HNEQLQF; -.
DR OrthoDB; 324879at2759; -.
DR Proteomes; UP000008141; Unassembled WGS sequence.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR Gene3D; 3.30.457.50; Chromosome segregation protein Spc25; 1.
DR InterPro; IPR045143; Spc25.
DR InterPro; IPR013255; Spc25_C.
DR PANTHER; PTHR14281:SF0; KINETOCHORE PROTEIN SPC25; 1.
DR PANTHER; PTHR14281; KINETOCHORE PROTEIN SPC25-RELATED; 1.
DR Pfam; PF08234; Spindle_Spc25; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU367150};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU367150};
KW Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU367150};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU367150};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|RuleBase:RU367150};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU367150};
KW Nucleus {ECO:0000256|RuleBase:RU367150};
KW Reference proteome {ECO:0000313|Proteomes:UP000008141}.
FT DOMAIN 155..224
FT /note="Chromosome segregation protein Spc25 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08234"
FT COILED 43..123
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 247 AA; 27391 MW; 88527E36856063C5 CRC64;
MAARIDLQGL QRQLDSFQTK FHAWAQRTVA GAASLCDGHL GRLREFQAAI RGLEQQQAEL
EQRAADVKQR LAAEEGEVAG LQQELASIRE EQGKLPGLVR EVQEALEAEA DAFQRQEAAL
SNQEALKERK LGALHQALAM YQRRLGLDFQ HSEADGEQLR VVVTQVDPRD HARAFQFAVQ
VVGDNSYAVQ SCEPPLPRMA ELLAELNAGG SFSRFVRCVR REFQAVVAEE MQQQRAAPLP
PQPVAAC
//
