ID E2ADX3_CAMFO Unreviewed; 957 AA.
AC E2ADX3;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Coatomer subunit beta {ECO:0000256|ARBA:ARBA00017024, ECO:0000256|PIRNR:PIRNR005727};
DE AltName: Full=Beta-coat protein {ECO:0000256|ARBA:ARBA00030841, ECO:0000256|PIRNR:PIRNR005727};
GN ORFNames=EAG_13117 {ECO:0000313|EMBL:EFN68206.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN68206.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC complex is required for budding from Golgi membranes, and is essential
CC for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
CC {ECO:0000256|PIRNR:PIRNR005727}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC {ECO:0000256|PIRNR:PIRNR005727}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR005727}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR005727}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR005727};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR005727}. Cytoplasmic vesicle, COPI-coated
CC vesicle membrane {ECO:0000256|PIRNR:PIRNR005727}; Peripheral membrane
CC protein {ECO:0000256|PIRNR:PIRNR005727}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR005727}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; GL438827; EFN68206.1; -; Genomic_DNA.
DR RefSeq; XP_011256301.1; XM_011257999.2.
DR AlphaFoldDB; E2ADX3; -.
DR STRING; 104421.E2ADX3; -.
DR EnsemblMetazoa; XM_011257999.3; XP_011256301.1; LOC105251308.
DR GeneID; 105251308; -.
DR KEGG; cfo:105251308; -.
DR InParanoid; E2ADX3; -.
DR OMA; MDYIIPA; -.
DR OrthoDB; 151169at2759; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0030126; C:COPI vesicle coat; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR011710; Coatomer_bsu_C.
DR InterPro; IPR016460; COPB1.
DR InterPro; IPR029446; COPB1_appendage_platform_dom.
DR PANTHER; PTHR10635; COATOMER SUBUNIT BETA; 1.
DR PANTHER; PTHR10635:SF0; COATOMER SUBUNIT BETA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF07718; Coatamer_beta_C; 1.
DR Pfam; PF14806; Coatomer_b_Cpla; 1.
DR PIRSF; PIRSF005727; Coatomer_beta_subunit; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005727};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR005727};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005727};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005727}.
FT DOMAIN 24..525
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT DOMAIN 665..805
FT /note="Coatomer beta subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07718"
FT DOMAIN 812..942
FT /note="Coatomer beta subunit appendage platform"
FT /evidence="ECO:0000259|Pfam:PF14806"
FT REGION 493..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 957 AA; 105540 MW; E6FECCA8350C4646 CRC64;
MSTITEQPCY TLINIPTDTE PLNELQLKQD LEKGSVQTKI DSLKKTIHMI LSGERLPGLL
MTIIRFVLPL QNHTIKKLLL IFWEIVPKTS ADGKLLQEMI LVCDAYRKDL QHPNEFVRGS
TLRFLCKLKE PELLEPLMPA ITACLEHRHS YVRRNAVLAI FTIYRNFEFL IPDAPELIAK
YLEGEQDMSC RRNAFLMLLH ADQNRALAYL AACLDQVPSF GDILQLVIVE LIYKVCLANP
SERARFIRCI YSLLNSPSAA VRYEAAGTLV TLSSAPTAIK AAASCYIELV VKESDNNVKL
IVLDRLIAMK DSSVYERVLQ DLVMDVLRVL GSPALEVRTK TLALAMDLVT TRTIEEMVQL
LKKEVLRTAG GEHEDAGRYR QLLVRTLHAC SMKFADVAAT VIPVLTDFLS ESNEAAATDV
LVFVREAIQR FENLRPLIVE KLLEVFPHIR SVKVHRAALW ILGEYATSKE DIEAVMGRVR
AALGELPLLE AENKRQAGEK SEDGNSQAAP TQLVTSDGTY ATQSAFSATS ARKKEEKRPA
LVQYMMEGDF FIGASLATTL AKLALRYKTL ETNIQKSNRL QAEAMLIMSS MLQLGRSGLP
MKAMTHDDAE RISLCLRSLA CPTPIVQKVF TEGCRDALGR MLTAKAEEDS QNQKAKEKPG
SIVQVDDAIQ FLQLSRGSDL AGGAGDVFEQ SLSAAVAGRP GASGDAPAPS VLSKVTQLTG
FSDPVYAEAL VHVNQYDIVL DVLIVNQTED TLQNCTLELA TMGDLKLVER PQPIVLAPRD
FASIKANVKV ASTENGIIFG NIVYDVSGAG SDRSVVVLND IHIDIMDYIV PATCTDAEFR
QMWAEFEWEN KVSVNTTLSD LREYLAHLLK STNMRCLTPE KALSGQCGFM AANMYAKSIF
GEDALANLSI EKPLNKPDAP VVGHIRIRAK SQGMALSLGD KINSAQKGPQ TKVVQAA
//
