ID E2AEJ4_CAMFO Unreviewed; 826 AA.
AC E2AEJ4;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Rho GTPase-activating protein 26 {ECO:0000313|EMBL:EFN68151.1};
GN ORFNames=EAG_05540 {ECO:0000313|EMBL:EFN68151.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN68151.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
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DR EMBL; GL438862; EFN68151.1; -; Genomic_DNA.
DR RefSeq; XP_011256719.1; XM_011258417.1.
DR AlphaFoldDB; E2AEJ4; -.
DR STRING; 104421.E2AEJ4; -.
DR EnsemblMetazoa; XM_011258417.2; XP_011256719.1; LOC105251540.
DR GeneID; 105251540; -.
DR KEGG; cfo:105251540; -.
DR InParanoid; E2AEJ4; -.
DR OMA; CASQERY; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd07602; BAR_RhoGAP_OPHN1-like; 1.
DR CDD; cd11882; SH3_GRAF-like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF1; RHO GTPASE-ACTIVATING PROTEIN GRAF; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 270..374
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 388..573
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 767..826
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 644..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 24..58
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 656..670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 826 AA; 93999 MW; 68A46A49DFE60957 CRC64;
MGVGLKPLEF TDCLTDSPYF RENLHYHERE LEKTSQQIKR LVKEVKDLLL AAKNLSRAQR
AFSKTLQNFS FECIGESQTE DETHISQSLK EFGKLIASIE DERDRMLERA YDQIILPLEN
FRKVHIGGVK DGKKKFEKQT IKFCQSQERY LNLSTKKQDN VLQEADATLE MAERHFSQAS
LEYVFLLQEV QERKKFEFVE TLLGFMFGWL TFYHQGHEVA KDFKPYMTEL QLKIQKTREN
FLATRDKTES LMNKMKDMKK STVESGLNKL HSREGYLFLM ERKAFGTTWT KQYCTYQKDK
KEFTMIPYNQ LTGKFSSKET FTLASCIRRM SDTIEKRFCF DITAIDRPNV TYTFQALSEE
DRKLWMDAMD GKEPTFPRLG SSVKSEDMTL DENGFAFVSK CIAALEDRGL EEQGLYRVVG
VASKVTKLLT MGLDKRKVEK LNLNDRFEWE SKTITSALKT YLRTLSEPLM TFRYYNSFIT
AAKQETKETR INDIHNLVYR LPKTNFNMLI LLITHLCTVA KKSDKNLMTV GNLAVCFGPT
LLRPEEETVA SIMDIKFYNI VVEILIENCE RIIAGPPPDS SRITAVQAVV PNKSQCAKME
EGPTSSGNGT AFLRYPLHTA VAVTPATSSH AHLVTRSYYD GQPLTVVNKP PPTVDERNNG
DYEDLDNTSH RIPSYLDSRG GRIKLTNANL MYHSADKVLS GGNTSSSSES IASDPHPFTG
ELPVKQKRGT MISVHGYPTA YPQRSNSSIC PINTSPNSGR SSPGQMPGIW RVRTLYACMA
ENDGELSFEP NQIITNVKAS LEPGWLEGTL NGKTGLVPKN YVEQLP
//
