ID E2AGR0_CAMFO Unreviewed; 1817 AA.
AC E2AGR0;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Ryanodine receptor 44F {ECO:0000313|EMBL:EFN67323.1};
GN ORFNames=EAG_04784 {ECO:0000313|EMBL:EFN67323.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN67323.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004326}.
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DR EMBL; GL439408; EFN67323.1; -; Genomic_DNA.
DR STRING; 104421.E2AGR0; -.
DR InParanoid; E2AGR0; -.
DR OMA; TREFRCS; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.490.160; -; 1.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF8; RYANODINE RECEPTOR 44F-LIKE PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF01365; RYDR_ITPR; 1.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 2.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 1.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 1.
DR PROSITE; PS50188; B302_SPRY; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:EFN67323.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 87..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 438..663
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 892..1075
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1292..1514
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1225..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1306..1324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1817 AA; 205654 MW; B489AEF221F975E0 CRC64;
MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNIPPDLS QCVFVIEQAL SVRALQELVT
AAGSETVKRV GGLYTLLPSR DPRVRKCVWV TILFWYLSLP SAICLVIYEG GSVMSQARSL
WRLELARTKW AGGFINWLHP MRIRHLTTGR YLGVKENNEL YLVDRNEATI ETSTFCLRQE
KDDQKIVLED KDLEVIGLPI IKYGDSTVIM QHATTCLWVS YKSYETKKKG VGKVEEKQAV
LHEEGKMDDG LDFSRSQEEE SRTARVIRKC SSVFTQFITG LETLQVNRRA SMFFQNVNLN
EMVMCLEDLI NYFAQPEDDM EHEEKQNKFR ALRNRQDLFQ EEGILNLILE AIDKINVITS
QGFLVALSGD ESGQAWDQIS GYLYQLLAAI IKGNHTNCAQ FANSNRLNWL FSRLGSQASS
EGTGMLDVLH CVLIDSPEVL NMMRDEHIKV IISLLEKHGR DPKVLDVLCS LCVGNGVAVR
SSQNNICDFL LPGKNLLLQT QLVDHVASVR PNIFVGRVEG SALYQKWYFE VTVDHIEQTT
HMMPHLRIGW ANTAGYMPYP GGGEKWGGNG VGDDLYSFGF DGAYLWTGGR KTQVVQDATE
PYIRKSDVIG CALDLTVPVI TFTFNGNRIM GSFRNFNLDG MFFPAISCSS KLSCRFLLGG
DHGRLKFQPM EEFSPLVESL LPQQILSLDP CFYFGNMNKV VLAGPWLVED DTAFVPAPVD
TSMVNLPAYV EQIRDKLAEN IHEMWAMNKI EAGWIYGEVR DDLRKIHPCI VQFERLPAAE
KRYDTQLAVQ TLKTILALGY YITMDKPPSR IKTLRLPNEP FLQSSGYKPA PLDLSAITLT
PKMEELVDQL AENTHNLWAK ERISQGWTYG LNEDSEMRRS PHLVPYLKVD EAIKKANRDT
ASETVRTLLV YGYMLDPPTG EQHEALLLEA SKLRQQSFRT YRVEKHYAVS NGKWYFEFEV
LTAGPMRVGW AKADCTPGNM LGSDENTWAF DGYNVTKVHA GTHESFGHRY QVGDIVGCFI
DVADRTISFS LNGELLMDAL GGETSFADVQ GESFVPAFTL GVGQKAKLTF GQDVNTLKFF
TTCGLQEGYE PFCVNMNRLV TYWYTKDQPI FENTDDMADT RIDVARIPAG SDTPPCLKIS
HNTFETMEKA NWEFLRLSLP VICQSNFITE GEKLRRWQEI KMRQNKLLAE QIEQGQQAAP
SAHLEQIMKS GFSMSDIKDE MLKESPLPMQ RGKPARPPRK GSLYGSRNLE NAVSDAEMNG
YGEMNGDVKD EKKKRGRSPF RFFSRKAKSP DAKSKTPEPQ VRSDISDKST RTLGSKSAKT
PQIRVSTTDL KVVPPQIPDR SVPKTMSVLT GSGVEAIGNE IFDAECMKLM NEYFYGVRIF
PGQDPTHVYI GWVTSQYHLH TKDFNLSRVR KASVAIMDDY DRLVDQVDRQ SCYMVRADEL
YNEVTQDASG KGASQGMFVG CFVDIATGWV SFTCEGKETS HKFKMEPDTK LFPAIFVEAT
SKEILQIELG RTSTTLPLSA AVLQNSERHV IPQFPPRLKV QCLKPHQWAR VPNQSLQVHA
LKLSDIRGWS MLCEDAISML ALHIPEEDRC IDILELIEMD KLLSFHAHTL TLYAALCYQS
NYRAAHVLCQ HVDQKQLLYA IRAEYMSGPL RQGFYDLLIA LHLESHATTM EVGKNEYIIP
LGQELKDLYE NSEMRHSLRY LETESIRPQM KMTEISDQAI ENIKNLYSPY FPLDVVRDYV
MMALNQAVEV NQVHNRDPIG GSNENLFLPL LKLVDRLLLV GMLRNEDVIK LLIMINPETW
DPTFDKGKPI KKVTFNY
//
