ID E2AP91_CAMFO Unreviewed; 482 AA.
AC E2AP91;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Acetyl-CoA hydrolase {ECO:0000256|ARBA:ARBA00017958};
DE EC=3.1.2.1 {ECO:0000256|ARBA:ARBA00011920};
DE AltName: Full=Acetyl-CoA deacylase {ECO:0000256|ARBA:ARBA00029672};
GN ORFNames=EAG_05178 {ECO:0000313|EMBL:EFN64764.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN64764.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O = acetate + CoA + H(+); Xref=Rhea:RHEA:20289,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=3.1.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001831};
CC -!- SIMILARITY: Belongs to the acetyl-CoA hydrolase/transferase family.
CC {ECO:0000256|ARBA:ARBA00009632}.
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DR EMBL; GL441481; EFN64764.1; -; Genomic_DNA.
DR RefSeq; XP_011261592.1; XM_011263290.2.
DR AlphaFoldDB; E2AP91; -.
DR STRING; 104421.E2AP91; -.
DR EnsemblMetazoa; XM_011263290.3; XP_011261592.1; LOC105254538.
DR GeneID; 105254538; -.
DR KEGG; cfo:105254538; -.
DR InParanoid; E2AP91; -.
DR OMA; NPKMTAI; -.
DR OrthoDB; 5486434at2759; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0008775; F:acetate CoA-transferase activity; IEA:InterPro.
DR GO; GO:0003986; F:acetyl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006083; P:acetate metabolic process; IEA:InterPro.
DR Gene3D; 3.30.750.70; 4-hydroxybutyrate coenzyme like domains; 1.
DR Gene3D; 3.40.1080.20; Acetyl-CoA hydrolase/transferase C-terminal domain; 1.
DR Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 1.
DR InterPro; IPR026888; AcetylCoA_hyd_C.
DR InterPro; IPR038460; AcetylCoA_hyd_C_sf.
DR InterPro; IPR046433; ActCoA_hydro.
DR InterPro; IPR003702; ActCoA_hydro_N.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR21432:SF20; ACETYL-COA HYDROLASE; 1.
DR PANTHER; PTHR21432; ACETYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF13336; AcetylCoA_hyd_C; 1.
DR Pfam; PF02550; AcetylCoA_hydro; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Transferase {ECO:0000313|EMBL:EFN64764.1}.
FT DOMAIN 105..230
FT /note="Acetyl-CoA hydrolase/transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02550"
FT DOMAIN 318..472
FT /note="Acetyl-CoA hydrolase/transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13336"
SQ SEQUENCE 482 AA; 52709 MW; 7C69FCCF61A6B591 CRC64;
MAALKRITSL TRALATATST SRPCFHRAAK KTYFTYVNEP SMPIPGKQPC WLKTADEAIE
QAELDSDQLV YVQGAAATPV ESLRAMTDYG VRCDVRNVRL YHMHLEGAAP FAKPEYAKHF
RSISLFIGGN VRAAVNAGTA DCIPIFLHEI PRLFKEGYLK PHISLIHVSP PDEKGYCSLG
TSIDSVRSAV SHSKCIVALV NKYMPRTFGD AIIHESHLDF AVEHHQPLPV HPVTTPSKAE
QQIGKYIAEN LVVDGATLQL GIGSIPDAVL SLLANHKDLG IHSEMFSDGV VDLVNKGCIT
NNQKTMHRGR IVGSFCVGSE KLYDFMHNNP FIEMLVVDYV NDPRIVAQQP KMTAINSCIE
VDITGQICSD SIGTKMYSGF GGQLDFITGA AMSEDRQGKP IIALKSVTSK GQSKIQPVLT
SGAGVVTNRA VARYVVTEHG IASLFGKSLQ QRAYELIQVA HPDHREALEK SAFERLKMMP
AP
//
