ID E2APE4_CAMFO Unreviewed; 399 AA.
AC E2APE4;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Ras-related GTP-binding protein D {ECO:0000313|EMBL:EFN64689.1};
GN ORFNames=EAG_09669 {ECO:0000313|EMBL:EFN64689.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN64689.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
CC {ECO:0000256|ARBA:ARBA00007756, ECO:0000256|RuleBase:RU367014}.
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DR EMBL; GL441524; EFN64689.1; -; Genomic_DNA.
DR RefSeq; XP_011261682.1; XM_011263380.2.
DR AlphaFoldDB; E2APE4; -.
DR STRING; 104421.E2APE4; -.
DR EnsemblMetazoa; XM_011263380.3; XP_011261682.1; LOC105254599.
DR EnsemblMetazoa; XM_025410443.1; XP_025266228.1; LOC105254599.
DR GeneID; 105254599; -.
DR KEGG; cfo:105254599; -.
DR InParanoid; E2APE4; -.
DR OMA; ICNHQAS; -.
DR OrthoDB; 166730at2759; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR CDD; cd11385; RagC_like; 1.
DR Gene3D; 3.30.450.190; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR006762; Gtr1_RagA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039400; RagC/D.
DR PANTHER; PTHR11259:SF2; GH16429P; 1.
DR PANTHER; PTHR11259; RAS-RELATED GTP BINDING RAG/GTR YEAST; 1.
DR Pfam; PF04670; Gtr1_RagA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU367014};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU367014};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 399 AA; 44618 MW; A57710E145FE112D CRC64;
MDDDDHYPSG YDDHYQSGSF PKDFGYAPFD GETEGSMDPL AGEQKPRILL MGLRRSGKSS
IQKVVFHKMS PNETLFLEST NKIIKDDISN SSFVQFQIWD FPGQIDFFDP TFDSDMIFGG
CGALVFVIDA QDDYMEALNK LHITVTKAYK VNQAIKFEVF IHKVDGLSDD CKMETQRDIH
TRANDDLADA GCDQIHLSFH LTSIYDHSIF EAFSKVVQKL IPQLPTLENL LNILISNSAI
EKAFLFDVVS KIYIATDSSP VDMQSYELCC DMIDVVIDVS CIYGLREDLE AAAFDNQSSS
LIKLNNGTIL YLREVNKFLA LVCILREDNF DRQGVIDYNF LCFRKAIQQV FELRNKALAA
TNANNHSSSP VSANETSNVS TVSQTGTIGQ NGTVVIGQS
//
