ID E2B563_HARSA Unreviewed; 436 AA.
AC E2B563;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Lipase {ECO:0000256|PIRNR:PIRNR000862};
GN ORFNames=EAI_15925 {ECO:0000313|EMBL:EFN89157.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN89157.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN89157.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|PIRNR:PIRNR000862}.
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DR EMBL; GL445725; EFN89157.1; -; Genomic_DNA.
DR RefSeq; XP_011145158.1; XM_011146856.2.
DR AlphaFoldDB; E2B563; -.
DR STRING; 610380.E2B563; -.
DR ESTHER; harsa-e2b563; Acidic_Lipase.
DR EnsemblMetazoa; XM_011146856.2; XP_011145158.1; LOC105186562.
DR GeneID; 105186562; -.
DR KEGG; hst:105186562; -.
DR InParanoid; E2B563; -.
DR OMA; LPAMFNY; -.
DR OrthoDB; 3259424at2759; -.
DR PhylomeDB; E2B563; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR006693; AB_hydrolase_lipase.
DR InterPro; IPR025483; Lipase_euk.
DR PANTHER; PTHR11005:SF147; LIPASE-RELATED; 1.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR Pfam; PF04083; Abhydro_lipase; 1.
DR PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid degradation {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid metabolism {ECO:0000256|PIRNR:PIRNR000862};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..436
FT /note="Lipase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003157848"
FT DOMAIN 70..126
FT /note="Partial AB-hydrolase lipase"
FT /evidence="ECO:0000259|Pfam:PF04083"
FT ACT_SITE 203
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 376
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 407
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
SQ SEQUENCE 436 AA; 49536 MW; 3821240F0678C0EE CRC64;
MALGMRNVLF AFVVITILTE GESQLGVDFT FLQQVVVDYL FPKDPGLVRV RNMDQERGLG
GTIVLDFIGL VEQFGYPAEE HDITTEDGYN LQIHRIPGSP QWRKKEKKKI VFMQHGIFAS
SDSWVIFGPG KDLAFLLADQ GYDVWIGNVR GNSYGRSHVN MTVYDRKFWQ FSFHEMAIMD
LPAIFDYIFN HTGQKSMHYI GHSMGTTMLF ILLSMKPEYN AKIELSICFT PVASWKEVSP
TFRQIAYTAP VVTELLARYN VYDIFAQCAS IITTLRALCH DGAATQSICI TILFLIVGAD
PPQLNTTALP YLLSHIPAGT SVQTLHHFYQ NMFVDNFQSF DYGSEGNNER YKQKTPINYD
LSKITAPIAL FYASNDAVVA ETNVLEVAKH LPNVVLIEKV QYESFNHVDF LWGIDANILL
YDRVIDIIRR FNAKQN
//
