ID E2BF32_HARSA Unreviewed; 1032 AA.
AC E2BF32;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 08-NOV-2023, entry version 56.
DE SubName: Full=Tyrosine 3-monooxygenase {ECO:0000313|EMBL:EFN85710.1};
GN ORFNames=EAI_10523 {ECO:0000313|EMBL:EFN85710.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN85710.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN85710.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL447910; EFN85710.1; -; Genomic_DNA.
DR AlphaFoldDB; E2BF32; -.
DR STRING; 610380.E2BF32; -.
DR EnsemblMetazoa; XM_011139272.3; XP_011137574.1; LOC105182097.
DR EnsemblMetazoa; XM_011139274.3; XP_011137576.1; LOC105182098.
DR InParanoid; E2BF32; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR GO; GO:0042423; P:catecholamine biosynthetic process; IEA:InterPro.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR005962; Tyr_3_mOase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR NCBIfam; TIGR01269; Tyr_3_monoox; 1.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF15; TYROSINE 3-MONOOXYGENASE; 1.
DR Pfam; PF00351; Biopterin_H; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00372; FYWHYDRXLASE.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601273-2};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:EFN85710.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237}.
FT DOMAIN 220..566
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT REGION 70..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 399
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 404
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 444
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ SEQUENCE 1032 AA; 116723 MW; 86C17430C8F69DEB CRC64;
MMAVAAAQKN REMFAIKKSY SIENGYPARR RSLVDDARFE TLVVKQTKQS VLEEARQRAN
DTNVDQTITC AQEEQGQSEN YDVSSSDDEQ MESLVCAAKK QEAKAEAWSD SDGKPDDDYD
DDAGLTEEEV VLAKTITESP ESEHSVQKAA LVLRLREGIG SLGRILKTIE NFKGTVTHVE
SRPSKKEGVQ FEVLVKVDMS RQSLLQLIRN LRQSSALDGV TLLADNSVSI KDPWFPRHAS
DLDNCNHLMT KYEPDLDMNH PGFADKEYRA RRKVIAEIAF AYKYGDPIPS IPYTETENET
WSRVFNTVLD LVPKHACVEY QRVFKKLQEE RIFESHRIPQ LQEVSNFLKK NTGFTLRPAA
GLLTARDFLS SLAFRIFQST QYVRHINSPY HTPEPDCIHE LLGHMPLLAD PSFAQFSQEI
GLASLGASDE EIEKLSTIYW FTVEFGLCKE GPEVKAYGAG LLSAYGELLH ALSDKCEHRA
FDPPSTALQK YQDQEYQPIY YVAESFEDAK EKFRRWVATM SRPFEVRFNP HTQRVEVLDS
VDRLDGLIAQ LNTEMTHLTN AINKIKASFA VCYASIDLVA SGLKSVLDMS DNAHELDEAK
TNERDDQLEA QSIQELYRKA SVNDSKCRGK RHANRMDIDA DDDAPRRTRE RRQSRASRNA
KEKYQRHDNQ QHHHQRRHHQ DADIKDVSSR FCALIQPALE SPMRRVTMID EERASGNSSI
LQDASSRTRI AGCNMIADEV KDDTDSRQEE LTGDHEDCVA KDLSDAFPST LGEQLDRDTR
TDDGEILRRA TVRDNNRAIG QQQRSPSQLT VTNARSMTSN AIRGIRRKKS SLCEVKVAVI
GAPGVGKSAL TVRFLTRRYI GEYDHQSETR YKHEVLVDGE PILFEILDTC PKSEDELPSM
ETLQWADGLL LVYSITDRGS FNFVRKAKEA LAVADPEAAM PLALVGNKAD MVHLRQVSAE
EGEILAKDFE CWFSEITAAE QVAQVAESFH ELCREVLAAR RRNKQSLLDR MLGSNKTRAY
SRGKSDSALP KE
//
