ID E2BGW4_HARSA Unreviewed; 3498 AA.
AC E2BGW4;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000313|EMBL:EFN85096.1};
GN ORFNames=EAI_14892 {ECO:0000313|EMBL:EFN85096.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN85096.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN85096.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; GL448228; EFN85096.1; -; Genomic_DNA.
DR STRING; 610380.E2BGW4; -.
DR InParanoid; E2BGW4; -.
DR OMA; PSPMCRE; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 2.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 2.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EFN85096.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 3156..3484
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 2172..2206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2172..2203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3498 AA; 403020 MW; 182B2403644C0CD4 CRC64;
MHLLECDISQ MYSTIANYAL PLSFSEQDDS ANVENVCCYQ EALSNILCHM SDVTDEKINV
LVQLSIYTIK RFPDLEIFKN RLAISSLIKI ILNLASVDRS LLQRYLDNII YDGIAWSCSH
TLALDAELQR ELGYLKQPPI CYKNYLPLWT QLLNIKKYTL YCTVQLIAET LMNVCIMLIK
RLDIDVKQQY EDTVLSDVAL VQGAVNQADF RVFTNLVDLY VDVIDATDAS LYSSIIPDFL
HDIIRLSYKH PLISGFYRLA RIALKILDCT TEKEEKSETK NLVSSYLVNI LELLPTFSNE
LLITCLYLIL DEPGISYVAT AVSSARLVSA FRIAFTMGLS DLELAYSALD ALKTWTDTRQ
SREDECMNES LREIVPHLES YLRSTESAVE MLQELTTKKK AKFKRIGSTD NECTLRNFQR
RILLFFGSLD HDVLSSFLYE RSLNTGASWD RKDLLRYSLL LPDVRLTLHF DRILPRVIAL
ARDSSDRRTR IAACEVLHSM VTLVIGSMRN SFPNSDSFVR LYALLCPILL ALGCDSDEVV
QSLFQPFTLQ LMHWLSSQLK SLPSVISLVL DSIFNSLCDN ANPSLREFAG TCLAEFTSWS
IRQADECDMQ SNVHQIVRRI NYFAQHPSVR KRVAAAVAFN HLYRILREDD DTVSIYWLEM
FHCFVRSMDG CGDSSIRNAL DHIKKVMKVK ADILNVTAKD RKKPHDFDDT TLTHALYWLL
SQCGVLDEHC RATCKELYVD ISQYATCGSA QKTTQIFVDI YGIGRLNDII LRGLNPNAED
ISNDNIKLLL KALDYYTWLI KEKLLPIEIL FPNNVQEHLI FACIRNFSRQ FLQTATTTVA
KRLREIDERP NTLQCKAVIA TLNFVQVLLE CVNNIVDRIV LPESLWYESL FALTIECVMH
PRAIGFDVKN IKMMDELPHV LKSLLNNMNS QFSYTLKCSF RRCVLNTIQK YVPQMLNLRD
IAQSYSWDEQ IQHEEISDLV NRVSTIEQIF NFITSKYMMG LTRSDLSAQM FDYLRALMVL
QLRHEAPTME LLVRLMSNDT LVTGIDSMNI THGEYFQTKF SNVIFNHILA NVDSITFVLD
KLSQSNPVFL LKWTENALLH LKQNKRTSRE HVDHVNVIDV ILQRFACLQK TAIDSNVGSH
RERLISIYST AVHLISKPVE IKRNQLYSEL HDWIVQQLIE DHDIEYKTLI LRNFLICLTD
ATDRVEDKRN MYYLYLLKND RPSLSSNAMK VTNCFETLLV LLSVTGSIIV LDCLINFAAG
AGKSLFGDKL KEHLRRYYCR EIPDATERVL CSLEMTYQSF IRSVNVEEKL DILHEFLLPA
FDHCDAPTTE RFFERNIREL HAISRRNISD SINSELDLVS KIGCYQLMAI MCTRLEESKI
VDANGTIVRN AGLDNVQDGR ELVQSLFKDA LNVRKLKIQI RCRDIVRLLH CSAYNLTLAI
TSLKEDEQFY NIVFAENRDR GMFIWKNIID CEKHYQLSQI CGNSKSHCRE TTVNIKSSVI
DGGREGQASS QHRYSHIHSY DLLTCSLNEE INAYDFNKSV LLPASAAIPC GRSATINVIL
ESDDFNEHEC MPNICGILQR FSSLKKPEKM TKLAECLNYF VLGLQKDVPR NIQLFMLKIV
DNTANTVFKP YAKFMLPGIA QAVANYLKAN DLNYIITNVL NILISWRDKI NDESIGRKEV
QNLFEVLVQR VLVKSQISNK HIYNNNLELI RTIMKKWCLT ESIVCLTERL TIAMEATVDL
IVKLLCDNDE MAREIVDKNL TEDIVNPLLT PLRNWNAAEQ DIVRYCEFFG WWLKLRQSGI
RHRLQEDKRD EGMESATRKN QIQDVKQKIF NILNSPPKTT QRLVYIEKQL KRIVVLCKIC
PDLAVDYITI VIDITSTDKN RDYCLEIFAL AMPQFCDATI ILSNLHRIEL QSVFTNREVL
CEAKALQIVH KLVNTAISPA DLLPYVKLTI SCLEDDSTEH RKLVYNVLMS VYKKYFADSD
DENVTILRSE SARKLVVGLL DPSEELQTRI LRFWTEETDL STKKSKERLI AVLNLRTKMN
LHMNIKEEDA YTLFVPLLIL QLTKESRDYN EKMFHPLHNC TYEDYEISVF WRRRNLRYVT
PMFVDSLASQ MSCTLSQSVD DDRRIYKHPA SSHYPPYGVP RLRATQDLQF EPTMLDDEVA
MDMDVTATLN NPLLDDRFQR PTTSSGRSSQ LANSQSRRLP GFSASSSDVG EYIRRQHVRK
NMERQEMMKQ EHIRQRNSVK LYRKYRSGDF PDIAIPHSSL IEPLAQLMKL DEVIRKDITV
FLFRSLVEKT MEKEDSDNFR QSIVENLKQI LHDSEKGSAF NAVILETLLT LNVSDYDSCD
IVKVSKANNL NAIGILLLER SLHPEASYFD DFLPTPEKRM KKNEDDPDNW AEIDKWSQLA
SLYKSIDDVD VVFSIFHEQS YDKNIQEATI ANADGDWLRA NMAFKRAYES TMIVPSMHEY
CMEGLFELMN NLCDWSTTNE LMVRANGDLM NVWDKPWRDW MIPRLCDAYV YMTDDNCRDS
NITDRDLEVI YKLWILADNN PSRLERIKSL VGEDLVLSLL RKKMEANDLL NDLLDKIGEQ
WVKLNPLCTE LGMRKLRKLQ VMSDLHATLR VLHYTDEMDF FFDRMVTLLD FWTTKVPTTR
DNLIQWTKLA AYRSYSSRLF NKILDSNKSN KYAEKVQEIK TRIRQVDHYL RLGIVDAALK
QKHQYIAQKH LSHLEDVSIS LQPRRTLFEA RIKYLCASLE TDAHMKMRDY VTSWKYSHQL
LNQISDDDNV DVDTSIAVRE HIGALASTIE HLTNENDVFA AALLTGSNEA SIILQDIDAE
QGDNPANVRE LLLHYSLDKL KSCSDSAATA TRATASRNVG EHYYALTRHC HSQLTNGRIM
SEAERNDIFQ VFVFATLRAM YHDYHEATHY FPCLLSDEQL LQNGAARRTF EGECTRPQPW
LFLRWRDLLF SHLGTSIAAI IAPIVEKLAK TYPEAIAYTY LLATEKRSVI INDRRTQRIH
EILQDKLTEI EQFLSAMQYV VQPELYLKYY LNEAMELLHK GDRSAFESLL SKVYTPISTA
ANEKIPRPGS VYNVIAKHKS GIVALDPVNC DATRESVQRM KDLLDKSLRD RANKKRLKEY
SPFLHAYAGG NIEIPGQYTG NREPMPMRYH AKIARIEPIV EVMHSLRKPI RISMIGENGR
EYKFLVKFGE DLTVDHGLQQ LYTTMNRTLF NDAACRQRRL MIDTYEVIPL SRSFGLIQWI
EDTKSLDNLV SFTLSELESN QCDDNRANYT KWIKGAAPLS TRISDQYTAA TAKYSRTEVV
TKMKQLISNT KQTALRDTFM AISPSLESFV TLRRNFVASY ATMCVAHWIA GIGDRHLENI
LVVVSSGRCL GIDFGRAFDS SLRIPVPELV PFRLTPQILE LMRPFTEKHL FGTIMTHVVR
ALRNDKGPIL ACMNIFTHEP INRSSINDED TAINNLKGKQ VVGEASCCLG RMQSSIHLIF
QHSLLRKLRF QIGQRICY
//
