ID E2BKC4_HARSA Unreviewed; 2231 AA.
AC E2BKC4;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 03-MAY-2023, entry version 62.
DE SubName: Full=Rho GTPase-activating protein 21 {ECO:0000313|EMBL:EFN83848.1};
GN ORFNames=EAI_15730 {ECO:0000313|EMBL:EFN83848.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN83848.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN83848.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
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DR EMBL; GL448783; EFN83848.1; -; Genomic_DNA.
DR STRING; 610380.E2BKC4; -.
DR InParanoid; E2BKC4; -.
DR OMA; QQHRQVM; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF23; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008237}.
FT DOMAIN 59..159
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 977..1089
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1210..1403
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1467..1509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1524..1598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1625..1645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1696..1729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1779..1804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1867..2135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..800
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1095..1132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1537..1598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1708..1729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1779..1797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1867..1895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1896..1911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1912..1928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1935..1950
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1963..1979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1986..2008
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2016..2052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2067..2135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2231 AA; 248252 MW; 062945C56BE22EBF CRC64;
MADDRNNHRS FVRQSHVVGH LSPPPPAPGP ATGSSGVSGQ TSSSRYVQKE NTPPRGPRTL
LLRHGENGYG FTLRHFIVYP PESCCMLPGH ERTKIDEPMD TIFVKQVRAN SPAAEAGLRT
GDRVVSVDGT PTRGEQYASV VQRIQQAGPW LRLLVVSKED DILQRYFGET AHNPETNQRP
RLRSPERLSQ KQRRSISMIP GPSQRTRQSW VCSLPSSDSP ASDPSSSSSS SSHPNHEEAS
RRSQQQQQQQ QQQAFADNNS RMAPSMSTDS PYRRAQQIQQ PLTEAQIAGA LYDPSDDMVP
PAARNLQSLH ETTDVTSGSQ MYGRSSQDSR YDLYDRTRPE SVYSRPSNEQ IYDRINDPIY
ERVRVNETCF ANDQHHHHQL QSLHHYQPSS LLRYPVSHAE PQVPIYRPTK RMVARRASEG
SGCSNVSGMK HDSETASYGS FDALRSSEPG SSRLSIESRR DSSPVSKDSV SPYDSNSTLT
GNECSDDSVI MSRLRKSFEQ KAEFLRRPSH PIGWFVSGND ATSEPTSLPR SQASNGLNQA
VIQREFYARP QKLQRPIWPP GNEQQRQQSP TRRQSSMDGR SIPKSTVNLA GGKPSNQSVQ
RIKDVDSDSE YTKSQGDRGD QQQLVGDDQP VAGDHCYSLL YDDELAKETY LANAHGGGSG
KAAPEQQQQY RAMSKANFIN TLSRIHENVT STVGAIANQD MRNGTSSLPS SPGPDKKPGE
TKFPVPPQGL QIVSRRAKQF ESGRLLSDED EPASDRTNLY KSELSRLSNT RNVPNVAVRK
REFESKAESQ ESRRLPSRET KSLDTGAVSK GNRIIPIGSK HIHCEPPADY KESKAEMPIM
ETESVRLRAR SNSVESWEAT NGPARGSARH TWQTAEEDFA ERRSSTEDNT PVNGSSPNGS
TKNGVVLRRQ KNAQISDEDR ATRRVSYLKA TWSERMHVDS DLELSDTEPV HMHRSNSIAV
AHDTSNSCDG TAKDVEPVEQ EGSLHVKFTV LDGKRSTDRS WKQVWGVLRG PIIYFYKDRH
SQSPSLSTEN EANAGQTVDV RCSVVDVAED YTKRKHVLRI ANPTAEVLLQ TEDAASMALW
LRSLHSQAAA ERSSDVASCT SKQQAVPQTP TGPTTSSNAA VSPGNNQRLS PLPSHKGIKK
LTSFRNRSPT GQSPVNKTRK PSQTVEPLPS PKSKTWKGRM AKQFRRMHGQ TGAPSSPTAQ
LPPEGATFKV PLELCPRAPD SDVPMIVEIC TRIVEARGLE VVGIYRVPGN TAAISQLTDS
VNSGFNNVNF QDPRWSDVNV ISSLLKSFFR QLPDSLFTAE LYPMFIDADK IEDPQRRMTT
IRKLLRDLPE HHFETLKHLM LHLKKIVEHS ETNKMEAKNL AIVFGPTLVR ASGSRDNMVT
MVNDMSHQCK IVENLLNNVD WFFSEDDLDD LSRLSVNLSL PADSCEVEPT SNTNHSLLLN
NIQKIEGMRD MASARDIVSS IISAANKKIQ RRRKTQDEID NGEHDSDKAK AKQETENSPT
IRQSMALNER QCSVSEIVLM HESKNQSNHN MDRPDRSLSA DATTNGGSSN GASPNRSKYA
THSSSVDSPR LSSETGLSSA ETSSTVSSAS NQTKQENDEI AIRTYAGLSA TTQERIRRFE
QETRAMLQRD QHRQKREAEK REEERRRIEM EWQLAKREME NDDLLDSIVD TTVSPNLLSE
RLSGLNERLA DKSLMDLSER PVRDSRSRST TRSPLSLAMQ QQPTIHQKTQ ATNQLSNVLG
EKMNNGVIKK FKTDKDPSME SICLPPVRYG SLDSLHEVHN FSQSSPSPSQ QQRGVPGDVS
DDGSDLLTSL TTTFDRKWRS LVNQSSNQAQ PPLEAAACNK DGAEQQEQKA SASLKFKYPS
AEAYRDPSLH KSIDKSHLSR SKDDAPEKDT DSTVTDTHPS EAVTPNNDRS AGDKQQRSET
KTASGHGTDK TTEKTAANAS EKDEDQKTAD IGDCACTGSP KRYELPNATN LQEGKPTSAN
ACPEETDVDT KLEDGKGHHY ESGDSSYSNK LKKFESLTNF EARSRLKRSE SLNKRSESTA
SRLKRSESLN KHSSERLSSP TNGKLKRSES LNKHSDGRSE SPGSKLKRSE SLTKTEKTEC
NISKRRQSVR KESATKLKRK NGMPERSIKR RHTVGGTKDF DKVHWLDNKL QSEAERIIRS
DYRPKKSQLR TSSPDLSTNR VGMTTDASFL IEVSFRGPSN VVFNVTNTRP QSLPDASLAS
KVFKVPLESH V
//
