ID   E2BKT8_HARSA            Unreviewed;       591 AA.
AC   E2BKT8;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Ceramide transfer protein {ECO:0000256|ARBA:ARBA00021440};
DE   AltName: Full=Collagen type IV alpha-3-binding protein {ECO:0000256|ARBA:ARBA00031527};
GN   ORFNames=EAI_10223 {ECO:0000313|EMBL:EFN83687.1};
OS   Harpegnathos saltator (Jerdon's jumping ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX   NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN   [1] {ECO:0000313|EMBL:EFN83687.1, ECO:0000313|Proteomes:UP000008237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN83687.1,
RC   ECO:0000313|Proteomes:UP000008237};
RX   PubMed=20798317; DOI=10.1126/science.1192428;
RA   Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA   Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA   Wang J., Liebig J.;
RT   "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT   saltator.";
RL   Science 329:1068-1071(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-
CC         enine(out); Xref=Rhea:RHEA:45720, ChEBI:CHEBI:72959;
CC         Evidence={ECO:0000256|ARBA:ARBA00000074};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus
CC       {ECO:0000256|ARBA:ARBA00004555}.
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DR   EMBL; GL448826; EFN83687.1; -; Genomic_DNA.
DR   RefSeq; XP_011140753.1; XM_011142451.2.
DR   AlphaFoldDB; E2BKT8; -.
DR   STRING; 610380.E2BKT8; -.
DR   EnsemblMetazoa; XM_025305700.1; XP_025161485.1; LOC105183968.
DR   InParanoid; E2BKT8; -.
DR   OMA; GAEAKCH; -.
DR   OrthoDB; 5489052at2759; -.
DR   PhylomeDB; E2BKT8; -.
DR   Proteomes; UP000008237; Unassembled WGS sequence.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   CDD; cd13283; PH_GPBP; 1.
DR   CDD; cd08872; START_STARD11-like; 1.
DR   Gene3D; 3.30.530.20; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR041952; STARD11_START.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR19308:SF53; CERAMIDE TRANSFER PROTEIN; 1.
DR   PANTHER; PTHR19308; PHOSPHATIDYLCHOLINE TRANSFER PROTEIN; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF01852; START; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00234; START; 1.
DR   SUPFAM; SSF55961; Bet v1-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50848; START; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Collagen {ECO:0000313|EMBL:EFN83687.1};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008237}.
FT   DOMAIN          37..132
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          382..585
FT                   /note="START"
FT                   /evidence="ECO:0000259|PROSITE:PS50848"
SQ   SEQUENCE   591 AA;  67695 MW;  2442E1BE9CE0394B CRC64;
     MADEVVETIR LNNEDAECID AEIDGDDEEE GSDGVIVPEL QGTLSKWTNY IHGWQTRFIV
     LKDGTLSYYK SEQDSGFGCR GSISLYKANI KAHEFDECRF DVSVNDCLVW YLRARSPEEK
     QRWVDVLKSY KSESGYGSEN SLKRHGSAIS LVSNTQSTAS AGSFTKRGIR GLKEKLAEIE
     TFRDILIKQI DTLQKYFDNC AENAKNTSKK EKKIETMFNP AEQSVDFKGE AITFKATSEG
     VLATLQHCVE LMIQREDAWR RRWEKEVEKK RKLQELYKTL KDQVAMHHTG SPRSRVLIHG
     GPDYEEGPHS ALCDEEFYDA VETGLDKIEE ENQLRDRLKQ KSVSILTSPT ITASTHRLWP
     EIEKITMEQL HYARLGVGGA GGWQLFAEDG DMRMYRREEE ADGLVVDPLK ACHVVKGVTG
     HEVCEIFFSP EYRSGWEATL EDMTVVENIS KDTLLFLQTH KRIWPASQRD ALFWSHMRRV
     SDDQDRDAHD LWIVCNHSTE HPDYPPNAGK CVRVYLTVCL VCQTCIDPPK DEEEIKRENI
     TCKITYCSVV NPGGWAPASV LRAVYKREYP KFLKRFTNFC IDQCKSKPIT F
//