ID   E2C281_HARSA            Unreviewed;       837 AA.
AC   E2C281;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 59.
DE   SubName: Full=Protein ECT2 {ECO:0000313|EMBL:EFN77944.1};
GN   ORFNames=EAI_03410 {ECO:0000313|EMBL:EFN77944.1};
OS   Harpegnathos saltator (Jerdon's jumping ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX   NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN   [1] {ECO:0000313|EMBL:EFN77944.1, ECO:0000313|Proteomes:UP000008237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN77944.1,
RC   ECO:0000313|Proteomes:UP000008237};
RX   PubMed=20798317; DOI=10.1126/science.1192428;
RA   Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA   Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA   Wang J., Liebig J.;
RT   "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT   saltator.";
RL   Science 329:1068-1071(2010).
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DR   EMBL; GL452088; EFN77944.1; -; Genomic_DNA.
DR   AlphaFoldDB; E2C281; -.
DR   STRING; 610380.E2C281; -.
DR   InParanoid; E2C281; -.
DR   OMA; PIYDVHK; -.
DR   Proteomes; UP000008237; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:2000431; P:regulation of cytokinesis, actomyosin contractile ring assembly; IEA:InterPro.
DR   CDD; cd17732; BRCT_Ect2_rpt2; 1.
DR   CDD; cd01229; PH_Ect2; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 3.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR026817; Ect2.
DR   InterPro; IPR049396; ECT2_BRCT0.
DR   InterPro; IPR049395; ECT2_PH.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR16777; PROTEIN ECT2; 1.
DR   PANTHER; PTHR16777:SF2; PROTEIN ECT2; 1.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF21243; ECT2_BRCT0; 1.
DR   Pfam; PF21242; ECT2_PH; 1.
DR   Pfam; PF12738; PTCB-BRCT; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF52113; BRCT domain; 2.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..837
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003157971"
FT   DOMAIN          121..194
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          215..303
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          392..582
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
SQ   SEQUENCE   837 AA;  94032 MW;  698CBC9BB80D72A9 CRC64;
     MVLLVELVVL LPILLAGVVA LDDELKTLII PRKKRICLVG TACNDPALGH AALQFKVSVL
     KSETGAEYVE DTSYHTYFVL KQFEGPEFDT LCKSAHRILG PTALLQLAEK KDSLPSIKRP
     LYTQAMVGTV VVFSGFRAKE DELRKLANMI LSMGGSIRKE MGIKVTHLIA NHCSGEKYRY
     ADTFGLPIMS VEWIIALWNA KDDVSSYAKK LIATYKLKPF YGAKVCFFGF PEEEKKHMCE
     VLEQQGGEST EIDNPNCTHV VVDESNVNVL PNLGSVSAFI VKTGWFWTSV QNEAAADEKD
     YLFEHYLETV LSPNASGRRD SQQIAGQSVA LPKHPYWLGT PLSNFLQNGA DSPASVSGSF
     LDCTASPDKQ LLDDIPEVET IDIKKVRGNL SKRHQVFLEL VETESNYVGI LNTIMTLFKL
     PLENLIGKNG KELLNSTEAR IIFGNFPPIY DVHKQLLESL RYSATHWTED ISIGKIFLKF
     EPDLVKAYPP YVNFFENTKQ MLDQCDQNKP RFHAFLKNCQ TIPECGRQSL KELLIKPVQR
     LPSINLLLND ILKHTDKSNP DHSALEASIS CIKNVMTYIN EDKRKTERQL AMFDIFNEID
     NCPPHLVSSH RSFVAKCDVM ELTEGLSGRG DHLVLFLFTD TLEVCKKRSK AFNSLKSPNT
     MNGLQSSKLS QGKPYKHIKL LSLNTIRKVV DIRETEECHK VFALVVRSNQ ELKEKLFSFV
     ITDEEVNKTN YLRTLCRQMA IAICVADADT LLISHDSHQF EIDTSDIASG TLKKTIKFAS
     RTRARVGRAF SFNKTPSKLN RAMSTIMSPF GVPQNLAPTN QQRNQMRLGS CSNINVS
//