ID   E2C4W3_HARSA            Unreviewed;      1228 AA.
AC   E2C4W3;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Cytochrome P450 9e2 {ECO:0000313|EMBL:EFN77021.1};
GN   ORFNames=EAI_13271 {ECO:0000313|EMBL:EFN77021.1};
OS   Harpegnathos saltator (Jerdon's jumping ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX   NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN   [1] {ECO:0000313|EMBL:EFN77021.1, ECO:0000313|Proteomes:UP000008237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN77021.1,
RC   ECO:0000313|Proteomes:UP000008237};
RX   PubMed=20798317; DOI=10.1126/science.1192428;
RA   Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA   Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA   Wang J., Liebig J.;
RT   "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT   saltator.";
RL   Science 329:1068-1071(2010).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|ARBA:ARBA00001971};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}. Microsome membrane
CC       {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004174}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|ARBA:ARBA00010617}.
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DR   EMBL; GL452660; EFN77021.1; -; Genomic_DNA.
DR   AlphaFoldDB; E2C4W3; -.
DR   EnsemblMetazoa; XM_011152481.3; XP_011150783.2; LOC105190011.
DR   EnsemblMetazoa; XM_011152483.3; XP_011150785.1; LOC105190013.
DR   InParanoid; E2C4W3; -.
DR   OMA; SKCSCEF; -.
DR   Proteomes; UP000008237; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   CDD; cd11056; CYP6-like; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 4.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR24292; CYTOCHROME P450; 1.
DR   PANTHER; PTHR24292:SF105; CYTOCHROME P450 9AC1; 1.
DR   Pfam; PF00067; p450; 4.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 5.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004}; Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        591..611
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        720..744
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1228 AA;  143323 MW;  59423F3E2C2B20F8 CRC64;
     MKHGVPYKPS LGISWNLILQ RMHFADYCQY IYNYVPDAKY IGLMDMSTPV VLLRDPELIK
     DVMVKDFEHF PDHKTFSNEE FTYWMKRGVP HILSFGMFWT MFLRRLNFAE YCQYLYNYMP
     DAKYIGLMSM GTPLVLLRDP ELIKNVMVKD FEHFPDHKTF LNEEVDPLFC KNIFSLRGNR
     WKEMRSTLSP SFTASKMKVM FELVSKCSCE FTKYLSDHPE RCSSIDAKEA FRRYTTDVIA
     TSAFGISVNS MKDRNNEFFI KGLDISKTNN FKTIFTEFNL FIYNHVSDAK YIGLWDMATP
     LVLLRDPELI KDVMVKDFEH FPDHKGFASE EVDPLFGKNV FSLRGNRWKE MRTTLSPSFT
     ASKMKVMFEL VSKCSYEFAE YLADHPELCS SIDTKESFRR YTTDHIYWKK RGVPQIRGIP
     GMKVGWKLLL QRINFTEYSQ FIYNDVPDAK YIGHMDMATP VVFLRDPELI KDVMVKDFEH
     FPDHRSFASE EVDPLFDKNV FALRGNRWKE MRNTLSPSFT ASKMKIMFEL VSKCSCEFAE
     YLADHPEQCA SIDTKEAFRR YTTDRHSYSF SGSLITMESS SFSLSLFSSP FALLLTTLVT
     IGVLKVIAYL YHQHMYWKKR GVPQIRTIVG LEIFWKLLLR RISFTEHNQF IYNYVPDAKY
     IGLMSMATPL VLLRDPELIK DVMVKDFEHF PDHKSIASEE VDPLFDSLIT MESLFLSSSF
     LSPLAILLTT LVIIIVLKVI AFVYHQQTYW KKRNVPYIHT IPSMKISLRA LLRHIDFTEY
     NQFIYNYVSD AKYIGLMSLN TPLVLLRDPE LIKDVMVKDF EHFPDHKSIL SEEVEPLFSR
     NVVALRGNRW KEMRNTLSPS FTASKMKIMF ELVSKCSCEF AEYLADHPEL CSSIDTKEAF
     RRYTTDVIAT SAFGISVNSM KDRDNEFFIR GIEATTFSGF KMMLKFIFIR VCPRLTKMLG
     ISVFSSVTSQ FFKRIVAEAI RVRDEQGIVR PDMIHLLMQA RDKKGPNVHE VTLDDIVAQA
     FIFFLAGFDT SATLMCFLAH ELAVHRDIQD RLWEEVEKHF AEGNGEITYE AMSKMVYMDM
     VVSEALRKYP PAAFIDRLCV KKYELPPAKA GYKNVVIEPD FMMLMPVYAL HHDSKYFSNP
     SKFDPERFSD ENKDNIVPYT YMPFGHGPRK CIGNRFALME TKLLVAYLLR RFIFKTTEKT
     VEPIVFDKKQ FSLQPEGGFW IGLEKRQK
//