ID E2C9Q6_HARSA Unreviewed; 379 AA.
AC E2C9Q6;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=ethanolamine-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00024221};
DE EC=2.7.7.14 {ECO:0000256|ARBA:ARBA00024221};
DE AltName: Full=CTP:phosphoethanolamine cytidylyltransferase {ECO:0000256|ARBA:ARBA00031473};
GN ORFNames=EAI_05216 {ECO:0000313|EMBL:EFN75296.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN75296.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN75296.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.
CC {ECO:0000256|ARBA:ARBA00024191}.
CC -!- SIMILARITY: Belongs to the cytidylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010101}.
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DR EMBL; GL453897; EFN75296.1; -; Genomic_DNA.
DR AlphaFoldDB; E2C9Q6; -.
DR STRING; 610380.E2C9Q6; -.
DR InParanoid; E2C9Q6; -.
DR OMA; QCKYINA; -.
DR UniPathway; UPA00558; UER00742.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0004306; F:ethanolamine-phosphate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02174; CCT; 1.
DR CDD; cd02173; ECT; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR041723; CCT.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR044608; Ect1/PCYT2.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 2.
DR PANTHER; PTHR45780; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR45780:SF2; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 2.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 2.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:EFN75296.1};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFN75296.1}.
FT DOMAIN 12..136
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT DOMAIN 205..300
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 379 AA; 43135 MW; 8F55BDEEC7E74355 CRC64;
MTEGTRKEVR VWCDGCYDMV HFGHANSLRQ AKALGDYLVV GVHKDEEIAK HKGPPVFTEQ
ERYKMVRGIK WVDEVVEAAP YVTTLETLDK YNCDFCVHGD DITTTADGVD TYHLVKAAGR
YREVQRTAGV STTDLVGRML LMTRQHFRQG DSEYSVDREP SKRMGQDRTA RNPWTGCSQF
LPTTQKIIQF SDGKAPQPGD KIVYVAGAFD LFHVGHLDFL EVAKKEGDYL IVGLHTDPAV
NRYKCGNHPI MNLHERVLSV LACKYVNEVV IGAPYEVTRN LMEHFNVSVV CHGQTPIMPC
EDGSDPYAEP KRQNKFKLLD SGNDMTTEKI VERIILHRGA KALELKNSLI FLKKHLSHLW
IRLFGGKKWR KWTKQLSNN
//
