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Database: UniProt
Entry: E2CVB6_9ACTO
LinkDB: E2CVB6_9ACTO
Original site: E2CVB6_9ACTO 
ID   E2CVB6_9ACTO            Unreviewed;       172 AA.
AC   E2CVB6;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   RecName: Full=phenylalanine--tRNA ligase {ECO:0000256|ARBA:ARBA00012814};
DE            EC=6.1.1.20 {ECO:0000256|ARBA:ARBA00012814};
DE   Flags: Fragment;
GN   Name=pheS {ECO:0000313|EMBL:ACX37177.1};
OS   Actinomyces oris.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Actinomyces.
OX   NCBI_TaxID=544580 {ECO:0000313|EMBL:ACX37177.1};
RN   [1] {ECO:0000313|EMBL:ACX37177.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=R14746 {ECO:0000313|EMBL:ACX37177.1};
RA   Henssge U., Do T., Gilbert S.C., Radford D.R., Beighton D.;
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) +
CC         L-phenylalanyl-tRNA(Phe); Xref=Rhea:RHEA:19413, Rhea:RHEA-COMP:9668,
CC         Rhea:RHEA-COMP:9699, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:58095, ChEBI:CHEBI:78442,
CC         ChEBI:CHEBI:78531, ChEBI:CHEBI:456215; EC=6.1.1.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00000395};
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DR   EMBL; GQ354617; ACX37177.1; -; Genomic_DNA.
DR   AlphaFoldDB; E2CVB6; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR   GO; GO:0043039; P:tRNA aminoacylation; IEA:InterPro.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR002319; Phenylalanyl-tRNA_Synthase.
DR   PANTHER; PTHR11538:SF41; PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11538; PHENYLALANYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF01409; tRNA-synt_2d; 1.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   4: Predicted;
KW   Aminoacyl-tRNA synthetase {ECO:0000313|EMBL:ACX37177.1};
KW   Ligase {ECO:0000313|EMBL:ACX37177.1}.
FT   DOMAIN          37..145
FT                   /note="Aminoacyl-transfer RNA synthetases class-II family
FT                   profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50862"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACX37177.1"
FT   NON_TER         172
FT                   /evidence="ECO:0000313|EMBL:ACX37177.1"
SQ   SEQUENCE   172 AA;  18965 MW;  FD6D65125170693D CRC64;
     AEEEMLRTEA VDVTIPTSRT QAGARHPLDV LIDEVCDFFT SMGWSIAEGP EVEHEWFDFD
     ALNFDADHPA RQMQDTFYID GVSVGAGEGQ AANLVLRTHT SPVQARVMLE QQPPLYVACP
     GKVFRSDELD ATHTPVFHQV EGLAVDKGLT MAHLKGVLDH FAKAMFGPEA RT
//
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