ID E2CZP3_9POXV Unreviewed; 326 AA.
AC E2CZP3;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=M-T2 {ECO:0000313|EMBL:AFU77765.1};
DE SubName: Full=M2 {ECO:0000313|EMBL:ADK63638.1};
GN Name=m002L {ECO:0000313|EMBL:ADK63638.1};
GN Synonyms=M-T2 {ECO:0000313|EMBL:QAV38030.1}, m002R
GN {ECO:0000313|EMBL:AFU77765.1};
OS Myxoma virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX NCBI_TaxID=10273 {ECO:0000313|EMBL:ADK63638.1, ECO:0000313|Proteomes:UP000158288};
RN [1] {ECO:0000313|EMBL:ADK63638.1, ECO:0000313|Proteomes:UP000158288}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SG33 {ECO:0000313|EMBL:ADK63638.1};
RX PubMed=21470452; DOI=10.3201/eid1704.101146;
RA Camus-Bouclainville C., Gretillat M., Py R., Gelfi J., Guerin J.L.,
RA Bertagnoli S.;
RT "Genome sequence of SG33 strain and recombination between wild-type and
RT vaccine myxoma viruses.";
RL Emerg. Infect. Dis. 17:633-638(2011).
RN [2] {ECO:0000313|EMBL:AFU77600.1, ECO:0000313|Proteomes:UP000096711}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=England/Cornwall/4-54/1 {ECO:0000313|EMBL:AFU77600.1};
RX PubMed=23055928; DOI=10.1371/journal.ppat.1002950;
RA Kerr P.J., Ghedin E., Depasse J.V., Fitch A., Cattadori I.M., Hudson P.J.,
RA Tscharke D.C., Read A.F., Holmes E.C.;
RT "Evolutionary history and attenuation of myxoma virus on two continents.";
RL PLoS Pathog. 8:E1002950-E1002950(2012).
RN [3] {ECO:0000313|Proteomes:UP000291290, ECO:0000313|Proteomes:UP000291454}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aust/SA/Mt Gambier/01-2015 {ECO:0000313|EMBL:QAV38706.1},
RC Aust/SA/Mt Gambier/03-2015 {ECO:0000313|EMBL:QAV42762.1}, Aust/SA/Mt
RC Gambier/09-2015 {ECO:0000313|EMBL:QAV41410.1}, Aust/SA/Quorn/03-2016
RC {ECO:0000313|EMBL:QAV40058.1}, Aust/SA/Stewarts Range Rd/09-2015
RC {ECO:0000313|EMBL:QAV41748.1}, Aust/SA/Turretfield
RC {ECO:0000313|EMBL:QAV40396.1}, MYXV/AUS/1949
RC {ECO:0000313|EMBL:QAV38199.1}, and SLS/AUS/1956
RC {ECO:0000313|EMBL:QAV38030.1};
RA Eden J.-S., Kerr P.J., Holmes E.C.;
RT "Punctuated evolution of myxoma virus: rapid and disjunct evolution of a
RT recent viral lineage in Australia.";
RL J. Virol. 0:0-0(2019).
RN [4] {ECO:0000313|EMBL:QCO69332.1, ECO:0000313|Proteomes:UP000299834}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Toledo {ECO:0000313|EMBL:QCO69332.1};
RA Agueda-Pinto A., Lemos de Matos A., Abrantes M., Kraberger S., Gortazar C.,
RA McFadden G., Varsani A., Esteves P.J.;
RT "Identification of a recombinant Myxoma virus infecting Iberian hare.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; GQ409969; ADK63638.1; -; Genomic_DNA.
DR EMBL; JX565566; AFU77600.1; -; Genomic_DNA.
DR EMBL; JX565566; AFU77765.1; -; Genomic_DNA.
DR EMBL; MK388115; QAV38030.1; -; Genomic_DNA.
DR EMBL; MK388115; QAV38195.1; -; Genomic_DNA.
DR EMBL; MK388116; QAV38199.1; -; Genomic_DNA.
DR EMBL; MK388116; QAV38364.1; -; Genomic_DNA.
DR EMBL; MK388119; QAV38706.1; -; Genomic_DNA.
DR EMBL; MK388119; QAV38871.1; -; Genomic_DNA.
DR EMBL; MK388127; QAV40058.1; -; Genomic_DNA.
DR EMBL; MK388127; QAV40223.1; -; Genomic_DNA.
DR EMBL; MK388129; QAV40396.1; -; Genomic_DNA.
DR EMBL; MK388129; QAV40561.1; -; Genomic_DNA.
DR EMBL; MK388130; QAV40565.1; -; Genomic_DNA.
DR EMBL; MK388130; QAV40730.1; -; Genomic_DNA.
DR EMBL; MK388131; QAV40734.1; -; Genomic_DNA.
DR EMBL; MK388131; QAV40899.1; -; Genomic_DNA.
DR EMBL; MK388132; QAV40903.1; -; Genomic_DNA.
DR EMBL; MK388132; QAV41068.1; -; Genomic_DNA.
DR EMBL; MK388135; QAV41410.1; -; Genomic_DNA.
DR EMBL; MK388135; QAV41575.1; -; Genomic_DNA.
DR EMBL; MK388137; QAV41748.1; -; Genomic_DNA.
DR EMBL; MK388137; QAV41913.1; -; Genomic_DNA.
DR EMBL; MK388143; QAV42762.1; -; Genomic_DNA.
DR EMBL; MK388143; QAV42927.1; -; Genomic_DNA.
DR EMBL; MK836424; QCO69332.1; -; Genomic_DNA.
DR EMBL; MK836424; QCO69418.1; -; Genomic_DNA.
DR RefSeq; NP_051713.1; NC_001132.2.
DR RefSeq; NP_051879.1; NC_001132.2.
DR GeneID; 1670230; -.
DR GeneID; 932138; -.
DR KEGG; vg:1670230; -.
DR KEGG; vg:932138; -.
DR OrthoDB; 11333at10239; -.
DR Proteomes; UP000096711; Genome.
DR Proteomes; UP000158288; Genome.
DR Proteomes; UP000291290; Genome.
DR Proteomes; UP000291359; Genome.
DR Proteomes; UP000291454; Genome.
DR Proteomes; UP000292368; Genome.
DR Proteomes; UP000292684; Genome.
DR Proteomes; UP000292892; Genome.
DR Proteomes; UP000293046; Genome.
DR Proteomes; UP000293069; Genome.
DR Proteomes; UP000293753; Genome.
DR Proteomes; UP000293894; Genome.
DR Proteomes; UP000294008; Genome.
DR Proteomes; UP000299834; Genome.
DR GO; GO:0005031; F:tumor necrosis factor receptor activity; IEA:InterPro.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:InterPro.
DR CDD; cd15839; TNFRSF_viral; 1.
DR Gene3D; 2.60.240.20; -; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR010806; Poxvirus_TNF-rcpt-II_C.
DR InterPro; IPR011172; Poxvirus_TNF_rcpt-II.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR034059; TNFRSF_N_viral.
DR PANTHER; PTHR47386; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B; 1.
DR PANTHER; PTHR47386:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B; 1.
DR Pfam; PF07190; CrmD_SECRET; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PIRSF; PIRSF001790; TNF_C22L; 1.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206}.
FT REPEAT 27..61
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 27..61
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 63..104
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 63..104
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 40..53
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 43..61
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 64..79
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 86..104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 326 AA; 35208 MW; ABBF027E947292FF CRC64;
MFRLTLLLAY VACVYGGGAP YGADRGKCRG NDYEKDGLCC TSCPPGSYAS RLCGPGSDTV
CSPCKNETFT ASTNHAPACV SCRGRCTGHL SESQSCDKTR DRVCDCSAGN YCLLKGQEGC
RICAPKTKCP AGYGVSGHTR TGDVLCTKCP RYTYSDAVSS TETCTSSFNY ISVEFNLYPV
NDTSCTTTAG PNEVVKTSEF SVTLNHTDCD PVFHTEYYGT SGSEGAGGFF TGMDRYQNTT
KMCTLNIEIR CVEGDAVRTI PRTSDGVGVL SHSETITVIG GCLSDVNVDI EYSDSNHPEE
VDDFVEYHWG TRLRLFPSPK RCRLVS
//
