ID E2DQD1_HAECO Unreviewed; 585 AA.
AC E2DQD1;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=ACR-5-like protein {ECO:0000313|EMBL:ADN33419.1};
GN Name=acr-5H {ECO:0000313|EMBL:ADN33419.1};
OS Haemonchus contortus (Barber pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6289 {ECO:0000313|EMBL:ADN33419.1};
RN [1] {ECO:0000313|EMBL:ADN33419.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hc-CRA {ECO:0000313|EMBL:ADN33419.1};
RX PubMed=20838602; DOI=10.1371/journal.ppat.1001091;
RA Rufener L., Keiser J., Kaminsky R., Maser P., Nilsson D.;
RT "Phylogenomics of ligand-gated ion channels predicts monepantel effect.";
RL PLoS Pathog. 6:e1001091-e1001091(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GU109271; ADN33419.1; -; mRNA.
DR AlphaFoldDB; E2DQD1; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18997; LGIC_ECD_nAChR; 1.
DR CDD; cd19051; LGIC_TM_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR PANTHER; PTHR18945:SF526; ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE ACR-5; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 315..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..314
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 321..565
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 585 AA; 68708 MW; 9A97773CF1FEEFD6 CRC64;
MVIIILLTLT YTECLEKFGK QISLSTSTYS YKRWYDENRQ HSSELNNGLQ EEYHMHLRRS
LENGNATTLN RTFLAQLAEE RRKFFENLSA GAFMNDQRRL VDDLLDESYY EKHVHPRVDH
LKPTRINVSM SLYQILDVDE HSQSIVVNVW MVQNWYDEFL DWDPREYGML NKTIVPYDQI
WIPDIYLYNS EALERKKTES IMNAIVETGF WSNNSLGARV QLMFPAIYKL SYAMNVQWFP
YDSQNCTFII SSWTHDKATI DYWAEHPTVN LKNMARNDEW EVLGFEFERI EQIFKCCANP
WVLLYAHLVI RRKPLYYVIN LVIPTSIITI VAITGFFTPT STSSERDEKL YLGINTLLTM
SIMMLMVCNQ MPSTSSYVPL MSWYYLGIII VIVLGTLLAT IVLAIHGQKR HNRPLSRWAR
GLVLNRFVET FILRPPCALV DLWSEYGIVE ERRLSMSKLD PLLVQQLDPI SLMPPRPRAF
FGSISSNMSE TSSYSYTTRL ATLTRQYTTQ VRVKEKERQS FLLKQSHHAR SVKRQKMSRR
CALEWEYLAN VIDRVLLTVF FIVTMSLFLL LVAFDYLFTV HNHVQ
//
