ID E2FCJ7_9HIV1 Unreviewed; 262 AA.
AC E2FCJ7;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ADN07166.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ADN07166.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADN07166.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BREPM3503_07 {ECO:0000313|EMBL:ADN07166.1};
RX PubMed=20707640; DOI=10.1089/aid.2010.0023;
RA Teixeira D., Munerato P., Komninakis S.C., Fusuma E.E., Janini L.M.,
RA Sucupira M.C., Diaz R.S.;
RT "The detection of in vivo and in vitro HIV type 1 B/F profiles in Brazil
RT using a real-time PCR assay for five HIV type 1 genomic regions.";
RL AIDS Res. Hum. Retroviruses 26:981-990(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; HM118425; ADN07166.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ADN07166.1};
KW Virion {ECO:0000313|EMBL:ADN07166.1}.
FT TRANSMEM 140..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..181
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 182..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADN07166.1"
FT NON_TER 262
FT /evidence="ECO:0000313|EMBL:ADN07166.1"
SQ SEQUENCE 262 AA; 30991 MW; 87F20A1276BEFDA1 CRC64;
VQARQLLSGI VQQQNNLLRA IEAQQHXLQL TVWGIKQLQA RVLAVERYLK DQQLLGIWGC
SGKLICTTAV PWNNSWSNRS LDTIWNNMTW MEWEREIDNY TGLIYNLIEE SQNQQEKNEK
DLLELDKWAN LWTWFDITNW LWYIKLFIMI VGGLIGLRII FTVLSIVNRV RQGYSPLSFQ
TRLPTPRGPD RPEGIEEEGG ERGRDRSERL VTGFLALIWD DLRSLFLFSY HHLRDLLLIV
TRIVELLGRR GWEALKYWWN LL
//
