ID E2MVY0_CORAY Unreviewed; 867 AA.
AC E2MVY0;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=CORAM0001_2007 {ECO:0000313|EMBL:EEB63411.1};
OS Corynebacterium amycolatum SK46.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=553204 {ECO:0000313|EMBL:EEB63411.1, ECO:0000313|Proteomes:UP000003275};
RN [1] {ECO:0000313|EMBL:EEB63411.1, ECO:0000313|Proteomes:UP000003275}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK46 {ECO:0000313|EMBL:EEB63411.1,
RC ECO:0000313|Proteomes:UP000003275};
RA Sebastian Y., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Strausberg R.L., Nelson K.E.;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEB63411.1}.
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DR EMBL; ABZU01000005; EEB63411.1; -; Genomic_DNA.
DR RefSeq; WP_005510555.1; NZ_ABZU01000005.1.
DR AlphaFoldDB; E2MVY0; -.
DR eggNOG; COG2205; Bacteria.
DR Proteomes; UP000003275; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EEB63411.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EEB63411.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 629..863
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 867 AA; 95412 MW; F1D15904AD682F52 CRC64;
MAKRGKLKVY LGFAPGVGKT CAMLSEGHDL YSRGHEVVIG LVEHHGRERT KKLIEGLPVL
DCRKVSYRGN TYRELDVDAI IEMHPEVALV DELAHTVVTD EPDNEFVQQR KRWHDVYQLL
DAGIDVISTM NIQHLESLND VVAAVTGVRQ METVPDRVLR DADEIELIDL SPDALRIRLS
RGEIYRKEQA ELALRKYFRP GNLSALRELA LLWLADKVEE VLDAYREDEE IDDHWTTRER
VVVAVRDDEN AESMIRRGAR MSGRVAGREM IVVHITGEDD GLDRGYLRRL RKLQDLTESL
GGQWRTIVGD DVPGILLEFS RTVNASQLVI GSERGLRRYV GLSTSQRIID QAGPIDVHII
SSSSEKKAKR RKKLRSRFSK ERRITGWLLA LVGPVLLTLL LYQLDTGPEF LGVLLLTYLM
PIVFAAMAAG LVPALAAVVV SSILANWYFT TPVNTLTITE PASLAQILLF GVIAAAVATV
VERSERRREM ADRSLHQAVV MSELAHGVVH DGDNMSNLVH SLADTFSMER VDVQRYSSER
KKWLTIVTTA EHGLSEPWPT ELPMTKVSSG DDLRFVLSGR ELTAAETAMI AAHGSRIRAL
MDMEEIAAMR RATAALEAGN RVGSAVLTAV SHDLRTPLAS IKAAISSMNM EDVELDDETR
LILMETIESS ADRLEVVIGN LLDASRIDSS TKRVESVPVS VSDVVDAVCA ELPEAAGHID
RDIDHDACMV EGDPGLIQRI VSNIVINGRQ YAPESSLTIR TRPSERGVRG PADMPVMGSL
GAIAASACID ILIIDHGKGI PEDKLEEIFQ PFQRLGDYSA QSQGLGLGLA AASRFADAMG
GAIRAEQTPG GGATFVLTLP RAMGERK
//
