ID E2Q834_STRCL Unreviewed; 364 AA.
AC E2Q834;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=LacI-family transcriptional regulator {ECO:0000313|EMBL:EFG05366.1};
GN ORFNames=SCLAV_0290 {ECO:0000313|EMBL:EFG05366.1};
OS Streptomyces clavuligerus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1901 {ECO:0000313|EMBL:EFG05366.1, ECO:0000313|Proteomes:UP000002357};
RN [1] {ECO:0000313|EMBL:EFG05366.1, ECO:0000313|Proteomes:UP000002357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 /
RC NRRL 3585 / VKM Ac-602 {ECO:0000313|Proteomes:UP000002357};
RX PubMed=20624727; DOI=10.1093/gbe/evq013;
RA Medema M.H., Trefzer A., Kovalchuk A., van den Berg M., Mueller U.,
RA Heijne W., Wu L., Alam M.T., Ronning C.M., Nierman W.C., Bovenberg R.A.L.,
RA Breitling R., Takano E.;
RT "The sequence of a 1.8-mb bacterial linear plasmid reveals a rich
RT evolutionary reservoir of secondary metabolic pathways.";
RL Genome Biol. Evol. 2:212-224(2010).
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DR EMBL; CM000913; EFG05366.1; -; Genomic_DNA.
DR AlphaFoldDB; E2Q834; -.
DR STRING; 1901.BB341_26325; -.
DR eggNOG; COG1609; Bacteria.
DR OrthoDB; 3595338at2; -.
DR Proteomes; UP000002357; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06267; PBP1_LacI_sugar_binding-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR30146:SF138; HTH-TYPE TRANSCRIPTIONAL REGULATOR KDGR; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF00532; Peripla_BP_1; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000002357};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 26..80
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 364 AA; 38051 MW; C58E2C0BE1B7F3B3 CRC64;
MADTVHPSLA SGRGSGAPER PWGNRPTMKD VAARAGVGLK TVSRVVNGEP GVTADTERRV
QEAIEALGFR RNDSARVLRK GRTASVGLVL EDLADPFYGP LSRAVEEVAR AHGALLINGS
SAEDPEREQE LALALCARRV DGLIVIPAGH DHRYLEPEIR AGVATVFVDR PAGLIDADTV
LSDSFGGARA GTAHLIAHGH RRIGFVGDRP RIHTAAERLR GYRAAMADAG LPVGPSWVSL
GPTAPERVRD AVRAMLTGPE PVTAVLAGNN RVTVTAVRVL AGPRAAAGTG REHPVALVGF
DDLDLADLLG ITVVAQDARA LGRTAAEQLF RRLDGAGGEP VRVTLATELI PRGSGEIPPP
AGTA
//
