ID E2QML5_ECOLX Unreviewed; 135 AA.
AC E2QML5;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Lactoylglutathione lyase {ECO:0000256|ARBA:ARBA00018701, ECO:0000256|RuleBase:RU361179};
DE EC=4.4.1.5 {ECO:0000256|ARBA:ARBA00012081, ECO:0000256|RuleBase:RU361179};
DE AltName: Full=Glyoxalase I {ECO:0000256|RuleBase:RU361179};
GN Name=gloA {ECO:0000313|EMBL:EFB5920875.1};
GN ORFNames=A2F99_002278 {ECO:0000313|EMBL:EFJ6910917.1}, A5U30_000956
GN {ECO:0000313|EMBL:EFM8153376.1}, A8502_003420
GN {ECO:0000313|EMBL:EFK3894685.1}, A8X14_000271
GN {ECO:0000313|EMBL:EFK4647365.1}, AAG80_001015
GN {ECO:0000313|EMBL:EFL5868242.1}, AAG81_002279
GN {ECO:0000313|EMBL:EFL5809861.1}, BMO21_003977
GN {ECO:0000313|EMBL:EFG6323176.1}, BO178_002651
GN {ECO:0000313|EMBL:EFG2488164.1}, CCV24_003647
GN {ECO:0000313|EMBL:EFF0468620.1}, CX690_000135
GN {ECO:0000313|EMBL:EFB6387579.1}, CX691_001331
GN {ECO:0000313|EMBL:EFB6306988.1}, CX692_002281
GN {ECO:0000313|EMBL:EFE8635582.1}, CX693_002319
GN {ECO:0000313|EMBL:EFE8626753.1}, CX694_002657
GN {ECO:0000313|EMBL:EFB6298638.1}, CX696_000744
GN {ECO:0000313|EMBL:EFB6282474.1}, CX699_002281
GN {ECO:0000313|EMBL:EFB6274421.1}, CYM75_000739
GN {ECO:0000313|EMBL:EFB5920875.1}, D1912_09430
GN {ECO:0000313|EMBL:RID05437.1}, D3C88_20840
GN {ECO:0000313|EMBL:RIB40029.1}, D4N09_09640
GN {ECO:0000313|EMBL:TXU36286.1}, D4U49_11375
GN {ECO:0000313|EMBL:EAB7203146.1}, D9J61_02300
GN {ECO:0000313|EMBL:EAC1530852.1}, EIMP300_50570
GN {ECO:0000313|EMBL:BBU83657.1}, EPS76_10745
GN {ECO:0000313|EMBL:RXD16411.1}, EWK56_01675
GN {ECO:0000313|EMBL:RYL85905.1}, F9U58_09800
GN {ECO:0000313|EMBL:EFE7310135.1}, FPI65_10195
GN {ECO:0000313|EMBL:NDR91643.1}, G3W53_07060
GN {ECO:0000313|EMBL:NEN69932.1}, GGB84_001871
GN {ECO:0000313|EMBL:HAG5770231.1}, GP711_19155
GN {ECO:0000313|EMBL:KAE9729098.1}, GQN34_19815
GN {ECO:0000313|EMBL:MWP26293.1}, GQW07_12135
GN {ECO:0000313|EMBL:EFH3508373.1}, GRC73_18580
GN {ECO:0000313|EMBL:HAH4525988.1}, GRO95_11380
GN {ECO:0000313|EMBL:EFH3409297.1}, HIE29_001009
GN {ECO:0000313|EMBL:HAH7767650.1}, HVV39_25685
GN {ECO:0000313|EMBL:QMS41141.1}, I4I37_01795
GN {ECO:0000313|EMBL:MBF9175071.1}, IFB95_001545
GN {ECO:0000313|EMBL:HAN4312787.1}, NCTC10767_05542
GN {ECO:0000313|EMBL:STC90617.1}, NCTC8621_02540
GN {ECO:0000313|EMBL:STH82545.1}, NCTC9001_02915
GN {ECO:0000313|EMBL:VFS18730.1}, NCTC9075_03252
GN {ECO:0000313|EMBL:STP19816.1}, NCTC9081_04353
GN {ECO:0000313|EMBL:STJ18853.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:EFB5920875.1};
RN [1] {ECO:0000313|Proteomes:UP000283846, ECO:0000313|Proteomes:UP000284508}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S308 {ECO:0000313|EMBL:RIB40029.1,
RC ECO:0000313|Proteomes:UP000284508}, and S339
RC {ECO:0000313|EMBL:RID05437.1, ECO:0000313|Proteomes:UP000283846};
RA Geslain G., Birgy A., Adiba S., Magnan M., Courroux C., Levy C., Cohen R.,
RA Bidet P., Bonacorsi S.;
RT "Genome sequencing of strains of the most prevalent clonal group of
RT O1:K1:H7 Escherichia coli that causes neonatal meningitis in France.";
RL BMC Microbiol. 0:0-0(2018).
RN [2] {ECO:0000313|EMBL:HAG5770231.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1839 {ECO:0000313|EMBL:HAG5770231.1}, 887_Uriselect
RC {ECO:0000313|EMBL:HAN4312787.1}, C0382
RC {ECO:0000313|EMBL:HAH7767650.1}, and EC00763
RC {ECO:0000313|EMBL:HAH4525988.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [3] {ECO:0000313|Proteomes:UP000254181, ECO:0000313|Proteomes:UP000254647}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC10767 {ECO:0000313|EMBL:STC90617.1,
RC ECO:0000313|Proteomes:UP000254647}, NCTC8621
RC {ECO:0000313|EMBL:STH82545.1, ECO:0000313|Proteomes:UP000255093},
RC NCTC9075 {ECO:0000313|EMBL:STP19816.1,
RC ECO:0000313|Proteomes:UP000254181}, and NCTC9081
RC {ECO:0000313|EMBL:STJ18853.1, ECO:0000313|Proteomes:UP000254716};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:EFG2488164.1, ECO:0000313|Proteomes:UP000523924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=142666 {ECO:0000313|EMBL:EFK4647365.1}, 151073
RC {ECO:0000313|EMBL:EFG6323176.1}, 155580
RC {ECO:0000313|EMBL:EFK3894685.1, ECO:0000313|Proteomes:UP000523924},
RC 278157 {ECO:0000313|EMBL:EFG2488164.1}, 587367
RC {ECO:0000313|EMBL:EAB7203146.1}, 854900
RC {ECO:0000313|EMBL:EFH3508373.1, ECO:0000313|Proteomes:UP000579110},
RC and 857239 {ECO:0000313|EMBL:EFH3409297.1,
RC ECO:0000313|Proteomes:UP000572731};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:TXU36286.1, ECO:0000313|Proteomes:UP000460654}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T0181B.E-10 {ECO:0000313|EMBL:TXU36286.1,
RC ECO:0000313|Proteomes:UP000460654};
RA Gasparrini A.J.;
RT "Persistent metagenomic signatures of early life antibiotic treatment in
RT the infant gut microbiota and resistome.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:EAC1530852.1, ECO:0000313|Proteomes:UP000382540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CVM N17EC1330 {ECO:0000313|EMBL:EAC1530852.1,
RC ECO:0000313|Proteomes:UP000382540};
RG NARMS: The National Antimicrobial Resistance Monitoring System;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:RXD16411.1, ECO:0000313|Proteomes:UP000288730}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=29_CAASB {ECO:0000313|EMBL:RXD16411.1,
RC ECO:0000313|Proteomes:UP000288730};
RA Potter R., Zou Z., Henderson J., Dantas G.;
RT "Genomic analysis of febrile catheter-associated UTI E. coli isolates.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:RYL85905.1, ECO:0000313|Proteomes:UP000291778}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCPM-O-B-8431 {ECO:0000313|EMBL:RYL85905.1}, and
RC SCPM-O-B-8431(U15) {ECO:0000313|Proteomes:UP000291778};
RA Slukin P., Fursova N., Ermolenko Z., Mayskaya N., Kislichkina A.,
RA Mukhina T., Sizova A., Bogun A.;
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:VFS18730.1, ECO:0000313|Proteomes:UP000372890}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC9001 {ECO:0000313|EMBL:VFS18730.1,
RC ECO:0000313|Proteomes:UP000372890};
RG Pathogen Informatics;
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:KAE9729098.1, ECO:0000313|Proteomes:UP000437875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TzEc067 {ECO:0000313|EMBL:KAE9729098.1,
RC ECO:0000313|Proteomes:UP000437875};
RA Subbiah M., Call D.R.;
RT "Antimicrobial-resistant enteric bacteria are widely distributed amongst
RT people, animals and the environment in northern Tanzania.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:MWP26293.1, ECO:0000313|Proteomes:UP000438259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10433wD12 {ECO:0000313|EMBL:MWP26293.1,
RC ECO:0000313|Proteomes:UP000438259};
RA Subbiah M., Call D.;
RT "Enteriobacteria Tanzani isolates_10433.";
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:NDR91643.1, ECO:0000313|Proteomes:UP000471490}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11230 {ECO:0000313|EMBL:NDR91643.1,
RC ECO:0000313|Proteomes:UP000471490};
RX PubMed=32021174;
RA Kedziora A., Wernecki M., Korzekwa K., Speruda M., Gerasymchuk Y.,
RA Lukowiak A., Bugla-Ploskonska G.;
RT "Consequences Of Long-Term Bacteria's Exposure To Silver Nanoformulations
RT With Different PhysicoChemical Properties.";
RL Int J Nanomedicine 15:199-213(2020).
RN [13] {ECO:0000313|EMBL:BBU83657.1, ECO:0000313|Proteomes:UP000467488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E300 {ECO:0000313|EMBL:BBU83657.1,
RC ECO:0000313|Proteomes:UP000467488};
RA Abe R., Akeda Y., Sugawara Y., Yamamoto N., Tomono K., Takeuchi D.,
RA Kawahara R., Hamada S.;
RT "Dynamics of blaIMP-6 dissemination in carbapenem resistant
RT Enterobacteriacea isolated from regional surveillance in Osaka, Japan.";
RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:EFB5920875.1, ECO:0000313|Proteomes:UP000555763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=03-3210 {ECO:0000313|EMBL:EFL5868242.1}, 04-3227
RC {ECO:0000313|EMBL:EFL5809861.1}, 07-4367
RC {ECO:0000313|EMBL:EFE8626753.1}, 07-4391
RC {ECO:0000313|EMBL:EFE8635582.1}, 08-3643
RC {ECO:0000313|EMBL:EFB6282474.1}, 2009C-3117
RC {ECO:0000313|EMBL:EFB5920875.1}, 2009C-3967
RC {ECO:0000313|EMBL:EFB6298638.1}, 2009C-4005
RC {ECO:0000313|EMBL:EFB6387579.1}, 2010C-3535
RC {ECO:0000313|EMBL:EFB6306988.1}, 2012C-3033
RC {ECO:0000313|EMBL:EFB6274421.1}, 2012C-4454
RC {ECO:0000313|EMBL:EFJ6910917.1}, 98-3217
RC {ECO:0000313|EMBL:EFF0468620.1}, PNUSAE002719
RC {ECO:0000313|EMBL:EFM8153376.1, ECO:0000313|Proteomes:UP000555763},
RC and PNUSAE035886 {ECO:0000313|EMBL:EFE7310135.1};
RG PulseNet: The National Subtyping Network for Foodborne Disease Surveillance;
RA Tarr C.L., Trees E., Katz L.S., Carleton-Romer H.A., Stroika S.,
RA Kucerova Z., Roache K.F., Sabol A.L., Besser J., Gerner-Smidt P.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:HAG5770231.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1839 {ECO:0000313|EMBL:HAG5770231.1}, 887_Uriselect
RC {ECO:0000313|EMBL:HAN4312787.1}, C0382
RC {ECO:0000313|EMBL:HAH7767650.1}, and EC00763
RC {ECO:0000313|EMBL:HAH4525988.1};
RG NCBI Pathogen Detection Project;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [16] {ECO:0000313|EMBL:NEN69932.1, ECO:0000313|Proteomes:UP000471360}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=8375wB1 {ECO:0000313|EMBL:NEN69932.1,
RC ECO:0000313|Proteomes:UP000471360};
RA Subbiah M., Call D.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [17] {ECO:0000313|EMBL:QMS41141.1, ECO:0000313|Proteomes:UP000514533}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RHB01-C20 {ECO:0000313|EMBL:QMS41141.1,
RC ECO:0000313|Proteomes:UP000514533};
RA Shaw L.P.;
RT "REHAB project genomes.";
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
RN [18] {ECO:0000313|EMBL:MBF9175071.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E3 {ECO:0000313|EMBL:MBF9175071.1};
RA Hetsa B., Amoako D.G., Akebe A.L., Asante J., Essack S.Y.;
RT "Genomic surveiliance of eskapee pathogens from blood stream infections in
RT kzn.";
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the conversion of hemimercaptal, formed from
CC methylglyoxal and glutathione, to S-lactoylglutathione.
CC {ECO:0000256|RuleBase:RU361179}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-S-lactoylglutathione = glutathione + methylglyoxal;
CC Xref=Rhea:RHEA:19069, ChEBI:CHEBI:17158, ChEBI:CHEBI:57474,
CC ChEBI:CHEBI:57925; EC=4.4.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000817,
CC ECO:0000256|RuleBase:RU361179};
CC -!- COFACTOR:
CC Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC Evidence={ECO:0000256|RuleBase:RU361179};
CC Note=Binds 1 nickel ion per subunit. {ECO:0000256|RuleBase:RU361179};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR604361-3};
CC Note=Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are
CC bound between subunits. {ECO:0000256|PIRSR:PIRSR604361-3};
CC -!- PATHWAY: Secondary metabolite metabolism; methylglyoxal degradation;
CC (R)-lactate from methylglyoxal: step 1/2.
CC {ECO:0000256|ARBA:ARBA00005008, ECO:0000256|RuleBase:RU361179}.
CC -!- SIMILARITY: Belongs to the glyoxalase I family.
CC {ECO:0000256|ARBA:ARBA00010363, ECO:0000256|RuleBase:RU361179}.
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DR EMBL; AP022360; BBU83657.1; -; Genomic_DNA.
DR EMBL; AAAFOP010000027; EAB7203146.1; -; Genomic_DNA.
DR EMBL; AAAGZE010000002; EAC1530852.1; -; Genomic_DNA.
DR EMBL; AASGFF010000002; EFB5920875.1; -; Genomic_DNA.
DR EMBL; AASGIA010000038; EFB6274421.1; -; Genomic_DNA.
DR EMBL; AASGHU010000006; EFB6282474.1; -; Genomic_DNA.
DR EMBL; AASGHW010000009; EFB6298638.1; -; Genomic_DNA.
DR EMBL; AASGIB010000003; EFB6306988.1; -; Genomic_DNA.
DR EMBL; AASGID010000001; EFB6387579.1; -; Genomic_DNA.
DR EMBL; AASNXN010000005; EFE7310135.1; -; Genomic_DNA.
DR EMBL; AASGHY010000039; EFE8626753.1; -; Genomic_DNA.
DR EMBL; AASGHZ010000038; EFE8635582.1; -; Genomic_DNA.
DR EMBL; AASOVL010000008; EFF0468620.1; -; Genomic_DNA.
DR EMBL; AASSIV010000012; EFG2488164.1; -; Genomic_DNA.
DR EMBL; AASTLX010000157; EFG6323176.1; -; Genomic_DNA.
DR EMBL; AASVOK010000021; EFH3409297.1; -; Genomic_DNA.
DR EMBL; AASVPF010000024; EFH3508373.1; -; Genomic_DNA.
DR EMBL; AATCOV010000038; EFJ6910917.1; -; Genomic_DNA.
DR EMBL; AATETU010000034; EFK3894685.1; -; Genomic_DNA.
DR EMBL; AATFCM010000001; EFK4647365.1; -; Genomic_DNA.
DR EMBL; AATIFT010000005; EFL5809861.1; -; Genomic_DNA.
DR EMBL; AATIGE010000003; EFL5868242.1; -; Genomic_DNA.
DR EMBL; AATLZG010000005; EFM8153376.1; -; Genomic_DNA.
DR EMBL; DAAYTU010000009; HAG5770231.1; -; Genomic_DNA.
DR EMBL; DABBJX010000023; HAH4525988.1; -; Genomic_DNA.
DR EMBL; DABCJL010000002; HAH7767650.1; -; Genomic_DNA.
DR EMBL; DABUHN010000004; HAN4312787.1; -; Genomic_DNA.
DR EMBL; WSGM01000013; KAE9729098.1; -; Genomic_DNA.
DR EMBL; JADQTC010000008; MBF9175071.1; -; Genomic_DNA.
DR EMBL; WTOC01000009; MWP26293.1; -; Genomic_DNA.
DR EMBL; VLTB01000180; NDR91643.1; -; Genomic_DNA.
DR EMBL; JAAGYP010000006; NEN69932.1; -; Genomic_DNA.
DR EMBL; CP055981; QMS41141.1; -; Genomic_DNA.
DR EMBL; QXHA01001398; RIB40029.1; -; Genomic_DNA.
DR EMBL; QWNV01001275; RID05437.1; -; Genomic_DNA.
DR EMBL; SCJN01000068; RXD16411.1; -; Genomic_DNA.
DR EMBL; SERV01000001; RYL85905.1; -; Genomic_DNA.
DR EMBL; UFXW01000004; STC90617.1; -; Genomic_DNA.
DR EMBL; UGBW01000003; STH82545.1; -; Genomic_DNA.
DR EMBL; UGCV01000008; STJ18853.1; -; Genomic_DNA.
DR EMBL; UGEM01000004; STP19816.1; -; Genomic_DNA.
DR EMBL; QYOH01000007; TXU36286.1; -; Genomic_DNA.
DR EMBL; CAADIS010000004; VFS18730.1; -; Genomic_DNA.
DR RefSeq; WP_001237802.1; NZ_WXYW01000001.1.
DR GeneID; 83576729; -.
DR OMA; THNWDTP; -.
DR OrthoDB; 9789841at2; -.
DR UniPathway; UPA00619; UER00675.
DR Proteomes; UP000254181; Unassembled WGS sequence.
DR Proteomes; UP000254647; Unassembled WGS sequence.
DR Proteomes; UP000254716; Unassembled WGS sequence.
DR Proteomes; UP000255093; Unassembled WGS sequence.
DR Proteomes; UP000283846; Unassembled WGS sequence.
DR Proteomes; UP000284508; Unassembled WGS sequence.
DR Proteomes; UP000288730; Unassembled WGS sequence.
DR Proteomes; UP000291778; Unassembled WGS sequence.
DR Proteomes; UP000372890; Unassembled WGS sequence.
DR Proteomes; UP000382540; Unassembled WGS sequence.
DR Proteomes; UP000437875; Unassembled WGS sequence.
DR Proteomes; UP000438259; Unassembled WGS sequence.
DR Proteomes; UP000460654; Unassembled WGS sequence.
DR Proteomes; UP000467488; Chromosome.
DR Proteomes; UP000471360; Unassembled WGS sequence.
DR Proteomes; UP000471490; Unassembled WGS sequence.
DR Proteomes; UP000514533; Chromosome.
DR Proteomes; UP000523924; Unassembled WGS sequence.
DR Proteomes; UP000555763; Unassembled WGS sequence.
DR Proteomes; UP000572731; Unassembled WGS sequence.
DR Proteomes; UP000579110; Unassembled WGS sequence.
DR Proteomes; UP000647581; Unassembled WGS sequence.
DR Proteomes; UP000843571; Unassembled WGS sequence.
DR Proteomes; UP000859922; Unassembled WGS sequence.
DR GO; GO:0004462; F:lactoylglutathione lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR CDD; cd16358; GlxI_Ni; 1.
DR Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 1.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR InterPro; IPR004361; Glyoxalase_1.
DR InterPro; IPR018146; Glyoxalase_1_CS.
DR InterPro; IPR037523; VOC.
DR NCBIfam; TIGR00068; glyox_I; 1.
DR PANTHER; PTHR46036; LACTOYLGLUTATHIONE LYASE; 1.
DR PANTHER; PTHR46036:SF5; LACTOYLGLUTATHIONE LYASE; 1.
DR Pfam; PF00903; Glyoxalase; 1.
DR SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 1.
DR PROSITE; PS00934; GLYOXALASE_I_1; 1.
DR PROSITE; PS00935; GLYOXALASE_I_2; 1.
DR PROSITE; PS51819; VOC; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU361179};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR604361-3,
KW ECO:0000256|RuleBase:RU361179}; Nickel {ECO:0000256|RuleBase:RU361179};
KW Zinc {ECO:0000256|PIRSR:PIRSR604361-3}.
FT DOMAIN 2..126
FT /note="VOC"
FT /evidence="ECO:0000259|PROSITE:PS51819"
FT ACT_SITE 122
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR604361-1"
FT BINDING 56
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared between dimeric partners"
FT /evidence="ECO:0000256|PIRSR:PIRSR604361-3"
FT BINDING 74
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared between dimeric partners"
FT /evidence="ECO:0000256|PIRSR:PIRSR604361-3"
FT BINDING 122
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared between dimeric partners"
FT /evidence="ECO:0000256|PIRSR:PIRSR604361-3"
SQ SEQUENCE 135 AA; 14906 MW; F53C1E2A462CB788 CRC64;
MRLLHTMLRV GDLQRSIDFY TNVLGMKLLR TSENPEYKYS LAFVGYGPET EEAVIELTYN
WGVDKYELGT AYGHIALSVD NAAEACEKIR QNGGNVTREA GPVKGGTTVI AFVEDPDGYK
IELIEEKDAG RGLGN
//
