UniProt: E2QN06

Database: UniProt
Entry: E2QN06_ECOLX

LinkDB:  E2QN06_ECOLX 
Original site:  E2QN06_ECOLX

All links

Ontology (6)   
   GO (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   EMBL (15)   
Protein domain (14)   
   InterPro (8)   
   Pfam (3)   
   PROSITE (1)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (38)   

Download RDF

ID   E2QN06_ECOLX            Unreviewed;       371 AA.
AC   E2QN06;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   RecName: Full=Ribonuclease D {ECO:0000256|HAMAP-Rule:MF_01899};
DE            Short=RNase D {ECO:0000256|HAMAP-Rule:MF_01899};
DE            EC=3.1.13.5 {ECO:0000256|HAMAP-Rule:MF_01899};
GN   Name=rnd {ECO:0000256|HAMAP-Rule:MF_01899,
GN   ECO:0000313|EMBL:NEN71187.1};
GN   ORFNames=A5U30_001108 {ECO:0000313|EMBL:EFM8153523.1}, C2121_000568
GN   {ECO:0000313|EMBL:EFA9667323.1}, CR628_003356
GN   {ECO:0000313|EMBL:EFC8021216.1}, D3G36_00930
GN   {ECO:0000313|EMBL:EFA4416459.1}, EPS76_02460
GN   {ECO:0000313|EMBL:RXD17923.1}, EWK56_00905
GN   {ECO:0000313|EMBL:RYL86032.1}, FEJ01_01620
GN   {ECO:0000313|EMBL:EFD1609958.1}, G3W53_13640
GN   {ECO:0000313|EMBL:NEN71187.1}, GRC73_10040
GN   {ECO:0000313|EMBL:HAH4524345.1}, HIE29_000855
GN   {ECO:0000313|EMBL:HAH7767502.1}, I4I37_09960
GN   {ECO:0000313|EMBL:MBF9176626.1}, NCTC10089_02131
GN   {ECO:0000313|EMBL:VTR18112.1}, NCTC10767_05696
GN   {ECO:0000313|EMBL:STC91045.1}, NCTC8621_02397
GN   {ECO:0000313|EMBL:STH82410.1}, NCTC8959_01652
GN   {ECO:0000313|EMBL:STE10988.1};
OS   Escherichia coli.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562 {ECO:0000313|EMBL:NEN71187.1, ECO:0000313|Proteomes:UP000471360};
RN   [1] {ECO:0000313|EMBL:HAH4524345.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C0382 {ECO:0000313|EMBL:HAH7767502.1}, and EC00763
RC   {ECO:0000313|EMBL:HAH4524345.1};
RX   PubMed=30286803;
RA   Souvorov A., Agarwala R., Lipman D.J.;
RT   "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL   Genome Biol. 19:153-153(2018).
RN   [2] {ECO:0000313|Proteomes:UP000254647, ECO:0000313|Proteomes:UP000255093}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC10767 {ECO:0000313|EMBL:STC91045.1,
RC   ECO:0000313|Proteomes:UP000254647}, NCTC8621
RC   {ECO:0000313|EMBL:STH82410.1, ECO:0000313|Proteomes:UP000255093}, and
RC   NCTC8959 {ECO:0000313|EMBL:STE10988.1,
RC   ECO:0000313|Proteomes:UP000255118};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:EFC8021216.1, ECO:0000313|Proteomes:UP000518092}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2017EL-1017b {ECO:0000313|EMBL:EFC8021216.1,
RC   ECO:0000313|Proteomes:UP000518092}, and PNUSAE002719
RC   {ECO:0000313|EMBL:EFM8153523.1, ECO:0000313|Proteomes:UP000555763};
RG   PulseNet: The National Subtyping Network for Foodborne Disease Surveillance;
RA   Tarr C.L., Trees E., Katz L.S., Carleton-Romer H.A., Stroika S.,
RA   Kucerova Z., Roache K.F., Sabol A.L., Besser J., Gerner-Smidt P.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:RXD17923.1, ECO:0000313|Proteomes:UP000288730}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=29_CAASB {ECO:0000313|EMBL:RXD17923.1,
RC   ECO:0000313|Proteomes:UP000288730};
RA   Potter R., Zou Z., Henderson J., Dantas G.;
RT   "Genomic analysis of febrile catheter-associated UTI E. coli isolates.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:RYL86032.1, ECO:0000313|Proteomes:UP000291778}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCPM-O-B-8431 {ECO:0000313|EMBL:RYL86032.1}, and
RC   SCPM-O-B-8431(U15) {ECO:0000313|Proteomes:UP000291778};
RA   Slukin P., Fursova N., Ermolenko Z., Mayskaya N., Kislichkina A.,
RA   Mukhina T., Sizova A., Bogun A.;
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:EFA4416459.1, ECO:0000313|Proteomes:UP000591371}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PSU-1190 {ECO:0000313|EMBL:EFA4416459.1,
RC   ECO:0000313|Proteomes:UP000591371};
RG   GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:EFD1609958.1, ECO:0000313|Proteomes:UP000562666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=470196 {ECO:0000313|EMBL:EFA9667323.1,
RC   ECO:0000313|Proteomes:UP000562788}, and 738634
RC   {ECO:0000313|EMBL:EFD1609958.1, ECO:0000313|Proteomes:UP000562666};
RA   Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL   Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:VTR18112.1, ECO:0000313|Proteomes:UP000406392}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC10089 {ECO:0000313|EMBL:VTR18112.1,
RC   ECO:0000313|Proteomes:UP000406392};
RG   Pathogen Informatics;
RL   Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:HAH4524345.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C0382 {ECO:0000313|EMBL:HAH7767502.1}, and EC00763
RC   {ECO:0000313|EMBL:HAH4524345.1};
RG   NCBI Pathogen Detection Project;
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:NEN71187.1, ECO:0000313|Proteomes:UP000471360}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=8375wB1 {ECO:0000313|EMBL:NEN71187.1,
RC   ECO:0000313|Proteomes:UP000471360};
RA   Subbiah M., Call D.;
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:MBF9176626.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E3 {ECO:0000313|EMBL:MBF9176626.1};
RA   Hetsa B., Amoako D.G., Akebe A.L., Asante J., Essack S.Y.;
RT   "Genomic surveiliance of eskapee pathogens from blood stream infections in
RT   kzn.";
RL   Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exonuclease involved in the 3' processing of various
CC       precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA
CC       molecule and releases 5'-mononucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_01899}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage that removes extra residues from the
CC         3'-terminus of tRNA to produce 5'-mononucleotides.; EC=3.1.13.5;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01899};
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01899};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01899}.
CC   -!- SIMILARITY: Belongs to the RNase D family. {ECO:0000256|HAMAP-
CC       Rule:MF_01899}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AASATZ010000001; EFA4416459.1; -; Genomic_DNA.
DR   EMBL; AASCIU010000003; EFA9667323.1; -; Genomic_DNA.
DR   EMBL; AASIMK010000024; EFC8021216.1; -; Genomic_DNA.
DR   EMBL; AASDTK010000002; EFD1609958.1; -; Genomic_DNA.
DR   EMBL; AATLZG010000005; EFM8153523.1; -; Genomic_DNA.
DR   EMBL; DABBJX010000008; HAH4524345.1; -; Genomic_DNA.
DR   EMBL; DABCJL010000002; HAH7767502.1; -; Genomic_DNA.
DR   EMBL; JADQTC010000129; MBF9176626.1; -; Genomic_DNA.
DR   EMBL; JAAGYP010000015; NEN71187.1; -; Genomic_DNA.
DR   EMBL; SCJN01000009; RXD17923.1; -; Genomic_DNA.
DR   EMBL; SERV01000001; RYL86032.1; -; Genomic_DNA.
DR   EMBL; UFXW01000004; STC91045.1; -; Genomic_DNA.
DR   EMBL; UFZD01000005; STE10988.1; -; Genomic_DNA.
DR   EMBL; UGBW01000003; STH82410.1; -; Genomic_DNA.
DR   EMBL; CABEEY010000003; VTR18112.1; -; Genomic_DNA.
DR   RefSeq; WP_001296131.1; NZ_WWEV01000080.1.
DR   OMA; TSGMHKV; -.
DR   Proteomes; UP000254647; Unassembled WGS sequence.
DR   Proteomes; UP000255093; Unassembled WGS sequence.
DR   Proteomes; UP000255118; Unassembled WGS sequence.
DR   Proteomes; UP000288730; Unassembled WGS sequence.
DR   Proteomes; UP000291778; Unassembled WGS sequence.
DR   Proteomes; UP000406392; Unassembled WGS sequence.
DR   Proteomes; UP000471360; Unassembled WGS sequence.
DR   Proteomes; UP000518092; Unassembled WGS sequence.
DR   Proteomes; UP000555763; Unassembled WGS sequence.
DR   Proteomes; UP000562666; Unassembled WGS sequence.
DR   Proteomes; UP000562788; Unassembled WGS sequence.
DR   Proteomes; UP000591371; Unassembled WGS sequence.
DR   Proteomes; UP000647581; Unassembled WGS sequence.
DR   Proteomes; UP000843571; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0033890; F:ribonuclease D activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042780; P:tRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR   CDD; cd06142; RNaseD_exo; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   HAMAP; MF_01899; RNase_D; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR006292; RNase_D.
DR   InterPro; IPR048579; RNAseD_HRDC_C.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   NCBIfam; TIGR01388; rnd; 1.
DR   PANTHER; PTHR47649; RIBONUCLEASE D; 1.
DR   PANTHER; PTHR47649:SF1; RIBONUCLEASE D; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   Pfam; PF21293; RNAseD_HRDC_C; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 2.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01899};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW   Rule:MF_01899};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01899, ECO:0000313|EMBL:NEN71187.1};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_01899};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694, ECO:0000256|HAMAP-
KW   Rule:MF_01899}.
FT   DOMAIN          206..285
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
SQ   SEQUENCE   371 AA;  42182 MW;  5909397EB24EBEF3 CRC64;
     MITTDDALAS LCEAVRAFPA IALDTEFVRT RTYYPQLGLI QLFDGEHLAL IDPLGITDWS
     PLKAILRDPS ITKFLHAGSE DLEVFLNVFG ELPQPLIDTQ ILAAFCGRPM SWGFASMVEE
     YSGVTLDKSE SRTDWLARPL TERQCEYAAA DVWYLLPITA KLMVETEASG WLPAALDECR
     LMQMRRQEVV APEDAWRDIT NAWQLRTRQL ACLQLLADWR LRKARERDLA VNFVVREEHL
     WSVARYMPGS LGELDSLGLS GSEIRFHGKT LLALVEKAQA LPEEALPQPM LNLMDMPGYR
     KAFKAIKSLI TDVSETHKIS AELLASRRQI NQLLNWHWKL KPQNNLPELI SGWRGELMAE
     ALHNLLQEYP Q
//

DBGET integrated database retrieval system