ID E2RTZ3_GIAIC Unreviewed; 449 AA.
AC E2RTZ3;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Protein disulfide isomerase PDI2 {ECO:0000313|EMBL:EDO80108.1};
GN ORFNames=GL50803_009413 {ECO:0000313|EMBL:KAE8304232.1}, GL50803_9413
GN {ECO:0000313|EMBL:EDO80108.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO80108.1};
RN [1] {ECO:0000313|EMBL:EDO80108.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO80108.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8304232.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8304232.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC {ECO:0000256|ARBA:ARBA00006347}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO80108.1}.
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DR EMBL; AACB02000012; EDO80108.1; -; Genomic_DNA.
DR EMBL; AACB03000002; KAE8304232.1; -; Genomic_DNA.
DR RefSeq; XP_001707782.1; XM_001707730.1.
DR AlphaFoldDB; E2RTZ3; -.
DR SMR; E2RTZ3; -.
DR STRING; 184922.E2RTZ3; -.
DR EnsemblProtists; EDO80108; EDO80108; GL50803_9413.
DR GeneID; 5700689; -.
DR KEGG; gla:GL50803_009413; -.
DR VEuPathDB; GiardiaDB:GL50803_9413; -.
DR HOGENOM; CLU_610372_0_0_1; -.
DR InParanoid; E2RTZ3; -.
DR OMA; NSTTQHH; -.
DR Proteomes; UP000001548; Chromosome 4.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003756; F:protein disulfide isomerase activity; IBA:GO_Central.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central.
DR CDD; cd02961; PDI_a_family; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 2.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR18929; PROTEIN DISULFIDE ISOMERASE; 1.
DR PANTHER; PTHR18929:SF132; PROTEIN DISULFIDE-ISOMERASE A3; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR Pfam; PF13848; Thioredoxin_6; 1.
DR PRINTS; PR00421; THIOREDOXIN.
DR SUPFAM; SSF52833; Thioredoxin-like; 2.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:EDO80108.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..449
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033695586"
FT TRANSMEM 381..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..121
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 339..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 50408 MW; 1A42BD13A4733BEF CRC64;
MVLGLLCTLA LLGSVSAEVL VLTQDNFKSE LEKHKNLFVK FYAPWCGHCK QLAPTWEEMS
GEFSVMPVAE VDCTTHTEIC GKYGVNGYPT IKLLQSNGAV MDYDGPREKQ SMMQWAEAML
KPALVEYNDI NDIKDKASKT SQPDIYYVME GPQLLDKFED FFTPMKGKHF FGFLKSAKEK
LYVMREGVKL DFKGKFDKAS VQAFLQDNRF PFFPELGPSN FQDLLKRPGR LLTFLAIDPS
EHEDTRSKLA SFARKLQTGV ADLDSKFVND YYTLTSIDGV QWAQFMEQFE IKKEDLPQLV
VYDVLAGSKK YFKASIGDSV VEDVTAFLRK HKSGAVPPSY MDKEEAKAAK KTAQGEEYTP
SGGNIADRIM EYMNTMLNEN FALFVAMVLI GSAIVMSLVV GCCCTGKKKR TPKKSPPKTA
KRDSESTDPK QSPKKASAVN KPAQEKRKK
//
