ID   E3BGN3_9VIBR            Unreviewed;       711 AA.
AC   E3BGN3;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE            EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN   ORFNames=VIBC2010_01059 {ECO:0000313|EMBL:EFP97841.1};
OS   Vibrio caribbeanicus ATCC BAA-2122.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=796620 {ECO:0000313|EMBL:EFP97841.1, ECO:0000313|Proteomes:UP000002943};
RN   [1] {ECO:0000313|EMBL:EFP97841.1, ECO:0000313|Proteomes:UP000002943}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-2122 {ECO:0000313|EMBL:EFP97841.1,
RC   ECO:0000313|Proteomes:UP000002943};
RX   PubMed=21930677; DOI=10.1099/ijs.0.032375-0;
RA   Hoffmann M., Monday S.R., Allard M.W., Strain E.A., Whittaker P., Naum M.,
RA   McCarthy P.J., Lopez J.V., Fischer M., Brown E.W.;
RT   "Vibrio caribbeanicus sp. nov., isolated from the marine sponge
RT   Scleritoderma cyanea.";
RL   Int. J. Syst. Evol. Microbiol. 62:1736-1743(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC         EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFP97841.1}.
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DR   EMBL; AEIU01000046; EFP97841.1; -; Genomic_DNA.
DR   AlphaFoldDB; E3BGN3; -.
DR   STRING; 796620.VIBC2010_01059; -.
DR   eggNOG; COG1505; Bacteria.
DR   OrthoDB; 9801421at2; -.
DR   Proteomes; UP000002943; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR   PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002943};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..711
FT                   /note="prolyl oligopeptidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003166668"
FT   DOMAIN          35..433
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          493..707
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   711 AA;  79896 MW;  0F6DC10EAE6A58E5 CRC64;
     MKIRILATIT TCFWLIAPTH AANTKQEKTM RIQYPTTKTV NIVDQYFGQL VTDPYRWLED
     DRSQETADWV KRQNTVTFDY LKRIPYREVI EQKLTRLMDY EKVGRPFTEG EYTYFFKNDG
     LQNQDVLYRR KGKDKPEVVL NPNAFSQDGT TSLDDVSFSD DGSMLAYSIS EDGSDWRKII
     IINSDSKAQI DTELVDIKFS NISWLKNEGF FYSSYEKPQG SELSAKTDQH KLYFHHIGQN
     QSQDTLVFGS NESEKYRYVS GSTSRDGRYL FISASNSTSG NKLFIKDLSI PNAPLTPIID
     NTKSDTWVVD TNGSTLYLAT NLNAPNQRVV KADAKQPQSE NWQDVIAENE HVLDVTAAGG
     FLFAHYMVDA TSVVKQFDRD GKWIRDIALP DIGSAEGFAA KLKDSTLYYT FTNYKTPDTT
     FELDIQSGKS TPFYTSNADF NPQNYESKQV FYKSKDGTKV PMIITYKKGI KLDGSNPTLL
     YGYGGFNISL TPNFRPTRAA WMELGGVYAV PNLRGGGEYG KEWHDAGTQM QKQNVFDDFI
     AAAEYLIDKG YTSPSKLAIS GGSNGGLLVG AAMTQRPELF QVALPAVGVL DMLRYHTFTA
     GAGWAYDYGT AEQSQSMFEY LKNYSPVHNV NVGTHYPATL VTTGDHDDRV VPAHSYKFAA
     QLQAKQTGSQ PTLIRIETDS GHGAGTPTHK IIDYYADTYS FTLHNMGIEK L
//